Antioxidant Levels in the Nasal Mucosa of Patients With Chronic Sinusitis and Healthy Controls

Westerveld, Gerrit-Jan; Dekker, Ingrid; Voss, Hans–Peter; Bast, Aalt; Scheeren, R. A.

doi:10.1001/archotol.1997.01900020089013

Cited by 30 publications

(21 citation statements)

References 23 publications

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“…They also suggested that oxidative stress may have a role in the etiopathogenesis of allergic rhinitis. Westerveld et al (1997) found that glutathione and uric acid, both known antioxidants, were decreased in the nasal mucosa of patients with chronic sinusitis, indicating that oxidative stress is related to the pathogenesis of upper airway tract diseases. Li et al (2011) reported that the total antioxidant capacity in an allergic rhinitis rat model was low.…”

Section: Discussionmentioning

confidence: 96%

“…Studies investigating the effect of oxidative stress on the upper airway tract reported that oxidative stress has a role in the etiopathogenesis of allergic rhinitis (Akbay et al, 2007;Emin et al, 2012). Westerveld et al (1997), reported that antioxidant mechanisms were decreased in the upper airway tract of patients with chronic sinusitis. The authors attributed this to the pathogenesis of upper airway diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model

Dokuyucu

Çevik

Özler

et al. 2014

European Journal of Pharmacology

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model

Dokuyucu

Çevik

Özler

et al. 2014

European Journal of Pharmacology

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“…Westerveld et al [5] found lower levels of glutathione and uric acid in the sinus mucosa of patients with sinusitis when compared to healthy subjects. This result indicates inflammatory consumption of antioxidants in sinus mucosa.…”

Section: Discussionmentioning

confidence: 97%

The role of oxidants and antioxidants in chronic tonsillitis and adenoid hypertrophy in children

Yılmaz

Koçan

Besler

2004

International Journal of Pediatric Otorhinolaryngology

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“…While extensive reviews have been published on the therapeutic potential of glutathione in the lower respiratory tract, 2 few have addressed the upper respiratory tract. Decreased levels of reduced glutathione have been observed in patients with chronic sinusitis, 17 providing scientific rationale for repletion as a therapeutic strategy. One study administered 600 mg GSH per day or placebo by nasal aerosol to children with chronic otitis media.…”

Section: Chronic Sinusitis/allergiesmentioning

confidence: 99%

Safety Survey of Intranasal Glutathione

Mischley

Vespignani²,

Finnell³

2013

The Journal of Alternative and Complementary Medicine

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Purpose: Glutathione depletion has been documented in several disease states, and exogenous administration has been hypothesized to have therapeutic potential for some conditions. In an effort to reach target tissues of the sinuses and central nervous system (CNS), glutathione is being prescribed as an intranasal spray, although no literature exists to support this mode of administration. The objective of this study was to describe patientreported outcomes in a population of individuals who have been prescribed intranasal reduced glutathione, (in)GSH. Methods: A survey was designed to assess individuals' perception of tolerability, adverse events, and health benefits associated with (in)GSH use. Using a pharmacy database, 300 individuals were randomly selected to receive a survey; any individual who had received one or more prescriptions for (in)GSH between March 2009 and March 2011 was eligible for participation. Results: Seventy (70) individuals returned the survey (23.3% response rate) from 20 different states. Reported indications for (in)GSH prescriptions were multiple chemical sensitivity (MCS) (n = 29), allergies/sinusitis (n = 25), Parkinson disease (PD) (n = 7), Lyme disease (n = 3), fatigue (n = 2), and other (n = 10). Of the respondents, 78.8% (n = 52) reported an overall positive experience with (in)GSH, 12.1% (n = 8) reported having experienced adverse effects, and 62.1% (n = 41) reported having experienced health benefits attributable to (in)GSH use. Over 86% of respondents considered the nasal spray to be comfortable and easy to administer. Conclusions: This is the first study to evaluate patient-reported outcomes among individuals across the country who have been prescribed (in)GSH. The majority of survey respondents considered (in)GSH to be effective and without significant adverse effects. (in)GSH should be further evaluated as a method of treating respiratory and CNS diseases where free-radical burden is a suspected contributor to disease progression.

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Antioxidant Levels in the Nasal Mucosa of Patients With Chronic Sinusitis and Healthy Controls

Cited by 30 publications

References 23 publications

Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model

Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model

The role of oxidants and antioxidants in chronic tonsillitis and adenoid hypertrophy in children

Safety Survey of Intranasal Glutathione

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