Antioxidant Levels in the Nasal Mucosa of Patients With Chronic Sinusitis and Healthy Controls

Reactive Oxygen Species Are Necessary for Bleomycin A5-Induced Apoptosis and Extracellular Matrix Elimination of Nasal Polyp-Derived Fibroblasts

“…19 Related studies have also shown that CRS mucosa have decreased levels of antioxidant enzymes, such as superoxide dismutase, when compared with NM. 22,23 Our results were consistent with data from those studies and suggest that an oxidant metabolic imbalance in fibroblasts from CRSwNP may contribute to the pathology of this disease.…”

Oxochromium(V) Species Formed with 2,3-Dehydro-2-deoxy-N-acetylneuraminic or N-Acetylneuraminic (Sialic) Acids: An In Vitro Model System of Oxochromium(V) Species Potentially Stabilized in the Respiratory Tract upon Inhalation of Carcinogenic Chromium(VI) Compounds

“…The pH dependence of the coordination modes of oxoCr-(V)-I or -II species observed here has implications with respect to the inhalation of Cr(VI) compounds, since the pH value of the nasal passage varies from pH 5.2 to pH 8.1 (45). Also, GSH is an antioxidant present in the human respiratory tract (together with uric acid (major) and vitamin E (minor)) (46), providing conditions with the potential to reduce Cr(VI) prior to the stabilization of oxoCr(V) species with mucin-derived I-type and/or II chelates. The solution of [Cr(V)-GSH]:[II] ) [40 mM]:[2 mM]:[100 mM] at pH ∼ 7.1 comprising oxoCr(V)-bis-II species, resulted in a strong oxoCr(V) EPR signal, and even after 24 h, its intensity was 36% of the maximum value (t ) 40 min).…”

The Role of Oxidants and Antioxidants in Otitis Media with Effusion in Children

“…The low level of antioxidants may be both the cause and the result of chronic infection. In patients with chronic sinusitis glutathione and uric acid concentrations in sinus mucosa were found low compared to healthy subjects 5 . OME may be the end result of interaction of multiple factors, such as infection, eustachian tube dysfunction, allergy, and barotrauma.…”