Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model

Dokuyucu, Recep; Çevik, Cengiz; Özler, Gül Soylu; Özgür, Tümay; Arlı, Cengiz; Sefil, Fatih; Yönden, Zafer

doi:10.1016/j.ejphar.2014.09.009

Cited by 2 publications

(2 citation statements)

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“…The end result is a tissue-protective effect that reduces lipid peroxidation, neutrophil infiltration, and cellular apoptosis mediated by harmful agents. It has been reported that erdosteine and vitamin B complex prevent the accumulation of free oxygen radicals and increase antioxidant cellular protective mechanisms [10,[17][18][19]. In our study, we observed the protective effects of erdosteine and vitamin B complex on biochemical parameters, oxidative stress, and histopathological parameters in the I/R model on rats as a preliminary experimental study.…”

Section: Discussionsupporting

confidence: 58%

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The Promising Effects of Erdosteine and Vitamin B in the Liver Ischemia/Reperfusion Model in Anesthetized Rats

Eygi,

Gul,

Aslan

et al. 2024

Medicina

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Background and Objectives: Erdosteine (Erd) is an antioxidant and anti-inflammatory drug. Vitamin B has been reported to exert anti-inflammatory and antioxidant effects. In this study, we investigated the effect of erdosteine and vitamin B complex on a liver ischemia/reperfusion (I/R) model. Materials and Methods: Thirty-two Wistar Albino male rats weighing 350–400 g were used. The animals were randomly selected and divided into four groups. The groups are as follows: first group (Sham), second group (I/R), third group (I/R + vit B), and fourth group (I/R + vit B + Erd). Rats were subjected to 45 min of hepatic ischemia, followed by a 45 min reperfusion period in the I/R and Vitamin B + Erd groups. An amount of 150 mg/kg/day of erdosteine was given orally for 2 days, and 0.05 mL/kg of i.p. vitamin B complex was given 30 min before the reperfusion. Serum biochemical parameters were measured. Serum Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) were measured, and the Oxidative Stress Index (OSI) was calculated. Hepatic tissue samples were taken for the evaluation of histopathological features. Results: In terms of all histopathological parameters, there were significant differences in the I/R + vit B group and I/R + vit B + Erd group compared with the I/R group (p < 0.01). In terms of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), TNF-alpha, and IL-6 levels, there were significant differences between the I/R group and treatment groups (p < 0.01). The lowest TOS and OSI levels were obtained in the treatment groups, and these groups had statistically significantly higher TAS levels compared with the sham and I/R groups (p < 0.01). Conclusions: As a preliminary experimental study, our study suggests that these agents may have potential diagnostic and therapeutic implications for both ischemic conditions and liver-related diseases. These results suggest that the combination of vit B + Erd may be used to protect against the devastating effects of I/R injury. Our study needs to be confirmed by clinical studies with large participation.

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Section: Discussionsupporting

confidence: 58%

“…Erdosteine is an antioxidant and anti-inflammatory drug. It inhibits the free oxygen radicals in the environment with the thiol groups it contains [6,9,10]. Vitamin B complex is a group of vitamins that are soluble in water and not stored in the body.…”

Section: Introductionmentioning

confidence: 99%