Antioxidant intake in paediatric oncology patients

Slegtenhorst, Sonja; Visser, Janicke; Burke, Amos

doi:10.1016/j.clnu.2014.12.010

Cited by 7 publications

(9 citation statements)

References 54 publications

(106 reference statements)

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“…Several studies have reported intakes of Mg (23) , Ca (18) , antioxidant vitamins (vitamins A, E and C) (7,21,(24)(25)(26)(27) , Zn and Cu (15,19) , Na (14) or of a variety of other micronutrients (8,17) during childhood cancer. Considering these studies, vitamin C was the vitamin for which the RNI was the most frequently reached by patients (7,25,27) . Conversely, one study conducted in Brazil found that, based on serum levels, 70 % of patients had vitamin C deficiency (serum levels below 0•2 mg/dl (11•4 μmol/l)) (26) .…”

Section: Food Habits During Treatment Of Cancermentioning

confidence: 99%

“…Moreover, it is important to point out that micronutrient intake below the RDA does not indicate deficiency, which requires clinical and biochemical assessments. However, seven of the thirteen studies that have evaluated micronutrients in paediatric cancer only gathered data on nutritional intake without considering deficiency (7,8,14,17,18,21,25) .…”

Section: Limitationsmentioning

confidence: 99%

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Food habits during treatment of childhood cancer: a critical review

2019

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Several factors can affect the nutritional status of children undergoing cancer therapy. The present review aims to describe children’s food intake during cancer treatments and to explore the contributing determinants. It also assesses the nutritional educational interventions developed for this clientele. Scientific literature from January 1995 to January 2018 was searched through PubMed and MEDLINE using keywords related to childhood cancer and nutritional intake. Quantitative and qualitative studies were reviewed: forty-seven articles were selected: thirty-eight related to food intake and parental practices and nine related to nutritional interventions. Patients’ intakes in energy, macronutrients and micronutrients were compared with those of healthy controls or with requirement standards. Generally, patients ate less energy and proteins than healthy children, but adhered similarly to national guidelines. There is a lack of consensus for standard nutrient requirement in this population and a need for more prospective evaluations. Qualitative studies provide an insight into the perceptions of children, parents and nurses on several determinants influencing eating behaviours, including the type of treatment and their side effects. Parental practices were found to be diverse. In general, savoury and salty foods were preferred to sweet foods. Finally, most interventional studies in childhood cancer have presented their protocol or assessed the feasibility of an intervention. Therefore, because of the variability of study designs and since only a few studies have presented results, their impact on the development of healthful eating habits remains unclear. A better understanding of children’s nutritional intakes and eating behaviours during cancer treatment could guide future nutritional interventions.

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Section: Food Habits During Treatment Of Cancermentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Food habits during treatment of childhood cancer: a critical review

2019

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“…Interestingly there were no significant associations between the polyphenol intake and food symptoms of cancer treatment, and many patients were not experiencing severe dietary symptoms. Previously, concerns for adverse food symptoms arising from treatment and cancer intensity as well as the survival outcomes from therapy have pushed prioritizing a high energy diet in childhood cancer care above a diet of good nutritional quality [4,54,55]. Studies in adults with cancer have suggested that increasing the intake of polyphenols during treatment may contribute to a reduction in symptoms from the toxicity of the cancer treatment and limiting cancer progression [14,19,27].…”

Section: Discussionmentioning

confidence: 99%

“…Studies in adults with cancer have suggested that increasing the intake of polyphenols during treatment may contribute to a reduction in symptoms from the toxicity of the cancer treatment and limiting cancer progression [14,19,27]. As cancer treatment in children has been linked with the depletion of their bodies’ stores of antioxidants, improving the dietary intake of children with cancer with a focus on polyphenols may have the potential to reduce their treatment-related side effects [55].…”

Section: Discussionmentioning

confidence: 99%

“…A high vegetable intake is vital in providing the necessary nutrients unavailable from other food groups, and is associated with reducing the risk of developing cancer and other chronic health conditions [65,66]. However, current nutritional recommendations for paediatric cancer patients focus on mitigating malnutrition by preventing weight loss rather than regulating the food groups from which the calories are sourced [2,55]. A healthy diet should be recommended for childhood cancer patients combining high-energy and high-quality food.…”

Section: Discussionmentioning

confidence: 99%

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Poor Dietary Polyphenol Intake in Childhood Cancer Patients

2019

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Emerging research demonstrates polyphenol-rich diets like the Mediterranean diet may play a role in improving the outcomes of adult cancer therapy. To date, there are no trials assessing the intake or efficacy of polyphenol-rich diets in childhood cancer patients. In this study we collected dietary data on 59 childhood cancer patients on treatment using a three-pass 24-h dietary recall (24-HDR), which is based on a validated and structured three-part methodology. Polyphenol consumption was calculated by matching the food consumption data with polyphenol content extracted from the most updated Phenol-Explorer database. The mean total polyphenol intake was 173.31 ± 141.02 mg/day. The major food sources of polyphenols were fruits, beverages, and cereals. There were no significant associations with time since diagnosis, body mass index (BMI) z-score, types of cancer, treatment intensity, food-related symptoms, relapse, and total daily polyphenol intake. Further investigation with larger studies will facilitate the steps in assessing the value of polyphenol-rich dietary patterns in future nutritional interventions for childhood cancer patients.

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