Retinol palmitate and ascorbic acid: Role in oncological prevention and therapy

Melo‐Cavalcante, Ana Amélia de Carvalho; Sousa, Leonardo da Rocha; Alencar, Marcus Viní­cius Oliveira Barros de; Santos, José Victor de Oliveira; Mata, Ana Maria Oliveira da; Paz, Márcia Fernanda Correia Jardim; Carvalho, Rezanio Martins; Nunes, Nárcia Mariana Fonseca; Islam, Muhammad Torequl; Mendes, Anderson Nogueira; Gonçalves, Juan Carlos Ramos; Silva, Felipe Cavalcanti Carneiro da; Ferreira, Paulo Michel Pinheiro; Sousaa, João Marcelo de Castro e

doi:10.1016/j.biopha.2018.10.115

Cited by 21 publications

(15 citation statements)

References 137 publications

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“…Ascorbic acid is also known as vitamin C, which is widely found in citrus fruits, strawberries, tomatoes, broccoli, Brussels sprouts, green peppers, red peppers, turnips, and other leafy vegetables [12][13][14]; small amounts have also been found in fish and milk (Figure 2) [12]. Subject to dose and route of administration, ascorbic acid exhibits either antioxidant or anticancer activity; at lower concentrations, it functions as an antioxidant, and at higher pharmacological concentrations, as a pro-oxidant [10].…”

Section: Natural Sourcesmentioning

confidence: 99%

“…Thus, finding new and effective drugs with fewer side effects is necessary for cancer treatment. Ascorbic acid (Figure 1) is a vital micronutrient in our bodies, possessing antioxidant [8][9][10] and anticancer activity [8,10]. Humans are incapable of producing ascorbic acid in their bodies due to the absence of the enzyme gluconolactone oxidase, which is required for the generation of ascorbic acid from glucose and galactose [11].…”

Section: Introductionmentioning

confidence: 99%

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Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

et al. 2021

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Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various developments to prevent and treat cancer, the side effects of anticancer drugs remain a major concern. Ascorbic acid is an essential vitamin required by our bodies for normal physiological function and also has antioxidant and anticancer activity. Although the body cannot synthesize ascorbic acid, it is abundant in nature through foods and other natural sources and also exists as a nutritional food supplement. In anticancer drug development, ascorbic acid has played an important role by inhibiting the development of cancer through various mechanisms, including scavenging reactive oxygen species (ROS), selectively producing ROS and encouraging their cytotoxicity against tumour cells, preventing glucose metabolism, serving as an epigenetic regulator, and regulating the expression of HIF in tumour cells. Several ascorbic acid analogues have been produced to date for their anticancer and antioxidant activity. The current review summarizes the mechanisms behind ascorbic acid's antitumor activity, presents a compilation of its derivatives and their biological activity as anticancer agents, and discusses delivery systems such as liposomes, nanoparticles against cancer, and patents on ascorbic acid as anticancer agents.

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Section: Natural Sourcesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

et al. 2021

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“…Their biological activity is apparently not relevant, as in the current study, their doses were only 1/100 and 1/3 of the dietary reference intakes and were lower than those reported in in vivo studies. 19 Iron homeostasis is often disturbed in cancer, and it plays an important role in cell division, growth, and metastasis. Anemia is often developed due to iron retention by cancer cells and cytostatic damage to bone marrow.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Polyphenolic Composition BP-C3 on the Efficacy and Hematological Toxicity of Cyclophosphamide in the Chemotherapy of Mice Bearing Soft Tissue Sarcomas Induced by Benzo[a]pyrene

Panchenko

Fedoros

Pigarev³

et al. 2019

Integr Cancer Ther

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This study aimed to evaluate the effect of lignin-derived polyphenolic composition BP-C3 on the efficacy and hematological toxicity of cyclophosphamide (CPA). Male and female Swiss-H derived mice bearing benzo[a]pyrene-induced soft tissue sarcomas were treated with CPA 300 mg/kg, BP-C3 75 mg/kg, or a combination. Tumor growth inhibition in male mice treated with CPA, BP-C3, or a combination of CPA and BP-C3 was significant and corresponded to 78%, 45%, and 82%, respectively, on day 21 after CPA administration on day 0. In female mice, tumor growth inhibition was 58%, −11%, and 35% when treated with CPA, BP-C3, or a combination of CPA and BP-C3, respectively. CPA administration resulted in significant hematological toxicity evidenced by a decreased white blood cell count on day 4 (2.43 ± 1.77 × 10 9 /L in male mice and 1.19 ± 0.71 × 10 9 /L in female mice) and anemia development on day 7 (6.55 ± 1.74 × 10 12 /L in male mice and 5.89 ± 2.24 × 10 12 /L in female mice). The red blood cell count measured on day 7 in animals treated with the combination of BP-C3 and CPA constituted 7.12 ± 1.17 × 10 12 /L and 7.36 ± 2.07 × 10 12 /L for male and female mice, respectively. The results of our study demonstrate the antitumor activity of BP-C3 in male mice bearing soft tissue sarcomas. Neither the antitumor activity nor the hematological toxicity of CPA were significantly influenced by BP-C3. A less pronounced effect of CPA on RBC count is demonstrated when this agent is given jointly with BP-C3.

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“…Moreover, vitamin D triggers the formation of antimicrobial peptides that may contribute to the wound healing process [12]. Vitamin A, despite not being a common antioxidant, is able to reduce oxidative stress [13] and even prevent the cancer risks of oxidative damage [14]. Recent studies have shown that vitamin A favors superoxide dismutase and glutathione transferase activities [15].…”

Section: Introductionmentioning

confidence: 99%

Endogenous Antioxidant Cocktail Loaded Hydrogel for Topical Wound Healing of Burns

et al. 2020

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The main goal of this work is the study of the skin wound healing efficacy of an antioxidant cocktail consisting of vitamins A, D, E and the endogenous pineal hormone melatonin (MLT), with all of these loaded into a thermosensitive hydrogel delivery system. The resulting formulation was characterized by scanning electron microscopy. The antioxidant efficacy and microbiological activity against Gram positive and Gram negative strains were also assayed. The skin healing efficacy was tested using an in vivo model which included histological evaluation. Furthermore, atomic force microscopy was employed to evaluate the wound healing efficacy of rat skin burns through the determination of its elasticity at the nanoscale using force spectroscopy analysis. The resulting hydrogel exhibited sol state at low temperature and turned into a gel at 30 ± 0.2 °C. The hydrogel containing the antioxidant cocktail showed higher scavenging activity than the hydrogel containing vitamins or MLT, separately. The formulation showed optimal antimicrobial activity. It was comparable to a commercial reference. It was also evidenced that the hydrogel containing the antioxidant cocktail exhibited the strongest healing process in the skin burns of rats, similar to the assayed commercial reference containing silver sulfadiazine. Histological studies confirmed the observed results. Finally, atomic force microscopy demonstrated a similar distribution of Young’s modulus values between burned skin treated with the commercial reference and burned skin treated with hydrogel containing the antioxidant cocktail, and all these with healthy skin. The use of an antioxidant cocktail of vitamins and MLT might be a promising treatment for skin wounds for future clinical studies.

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Retinol palmitate and ascorbic acid: Role in oncological prevention and therapy

Cited by 21 publications

References 137 publications

Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

The Effect of Polyphenolic Composition BP-C3 on the Efficacy and Hematological Toxicity of Cyclophosphamide in the Chemotherapy of Mice Bearing Soft Tissue Sarcomas Induced by Benzo[a]pyrene

Endogenous Antioxidant Cocktail Loaded Hydrogel for Topical Wound Healing of Burns

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