Poor Dietary Polyphenol Intake in Childhood Cancer Patients

Abstract

Emerging research demonstrates polyphenol-rich diets like the Mediterranean diet may play a role in improving the outcomes of adult cancer therapy. To date, there are no trials assessing the intake or efficacy of polyphenol-rich diets in childhood cancer patients. In this study we collected dietary data on 59 childhood cancer patients on treatment using a three-pass 24-h dietary recall (24-HDR), which is based on a validated and structured three-part methodology. Polyphenol consumption was calculated by matching the food consumption data with polyphenol content extracted from the most updated Phenol-Explorer database. The mean total polyphenol intake was 173.31 ± 141.02 mg/day. The major food sources of polyphenols were fruits, beverages, and cereals. There were no significant associations with time since diagnosis, body mass index (BMI) z-score, types of cancer, treatment intensity, food-related symptoms, relapse, and total daily polyphenol intake. Further investigation with larger studies will facilitate the steps in assessing the value of polyphenol-rich dietary patterns in future nutritional interventions for childhood cancer patients.

Dietary Polyphenols in Cancer Chemoprevention: Implications in Pancreatic Cancer

“…Epidemiological studies also support the fact that consumption of a natural polyphenol-enriched diet could reduce the incidence or lower the risk of pathophysiologies including cardiovascular diseases [12][13][14][15][16]. However, other reports have documented contrasting or inconsistent evidence for polyphenols intake against cardiovascular diseases and cancer [17][18][19][20]. This indicates the need for conducting further randomized controlled trials and observational or behavioral studies in human subjects with such disease conditions [17][18][19][20].…”

“…However, other reports have documented contrasting or inconsistent evidence for polyphenols intake against cardiovascular diseases and cancer [17][18][19][20]. This indicates the need for conducting further randomized controlled trials and observational or behavioral studies in human subjects with such disease conditions [17][18][19][20].…”

“…However, other reports have documented contrasting or inconsistent evidence for polyphenols intake against cardiovascular diseases and cancer [ 17 , 18 , 19 , 20 ]. This indicates the need for conducting further randomized controlled trials and observational or behavioral studies in human subjects with such disease conditions [ 17 , 18 , 19 , 20 ]. Nevertheless, experimental studies have characterized that polyphenolic derivatives, including quercetin, resveratrol, etc., possess several medicinal properties, including anti-inflammatory and antioxidant activities, and therefore, have been extensively explored for cancer chemoprevention in various cancer models including pancreatic cancer [ 7 , 8 , 9 , 10 , 11 , 21 ].…”