Antioxidant Enzyme and Malondialdehyde Levels in Patients with Panic Disorder

Kuloğlu, Murat; Atmaca, Murad; Tezcan, Ertan; Üstündağ, Bilal; Bulut, Serpil

doi:10.1159/000067810

Cited by 132 publications

(110 citation statements)

References 15 publications

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“…These have reported elevated lipid peroxidation products and antioxidant changes in obsessive-compulsive disorder (Ersan et al, 2006;Kuloglu et al, 2002a), panic disorder (Kuloglu et al, 2002b) and social phobia (Atmaca et al, 2004), but not in post-traumatic stress disorder (Tezcan et al, 2003). The study on social phobia also found a reversal of these disturbances following 8 wk of citalopram treatment (Atmaca et al, 2004).…”

Section: Human Studiesmentioning

confidence: 99%

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

872

569

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Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Previews, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.

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Section: Human Studiesmentioning

confidence: 99%

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

872

569

View full text Add to dashboard Cite

show abstract

“…ROS have been implicated as mediators of tissue damage in patients with rheumatoid arthritis. The synovial fluid of the inflamed rheumatoid joint swarms with activated neutrophils, which produce large amounts of ROS 2 . ROS are formed in oxidative processes that normally occur at relatively low levels in all cells and tissues.…”

Section: Introductionmentioning

confidence: 99%

Circulating lipid peroxidation, plasma and erythrocyte antioxidant status in patients with rheumatoid arthritis

Pasupathi¹,

Deepa²,

Rani³

et al. 2009

Bangladesh Med Res Counc Bull

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The aim of the study was to investigate the levels of lipid peroxidation, and both plasma and erythrocyte antioxidant states in patients with rheumatoid arthritis. The population consisted of 60 subjects divided into two groups, 30 subjects had evidence of rheumatoid arthritis and age and sex matched healthy subjects were studied as controls. The level of plasma and erythrocyte thiobarbituric acid reactive substances (TBARS) was markedly increased in both the rheumatoid arthritis patients when compared to control subjects. The activities of plasma and erythrocyte antioxidants were significantly decreased in rheumatoid arthritis. C reactive protein, rheumatoid factor and antistreptolysin-O were significantly higher in rheumatoid arthritis patients than in healthy subjects. In conclusion, on the basis of enhanced lipid peroxidation in rheumatoid arthritis patients with concomitant failure of both the plasma, and erythrocyte antioxidants defense mechanism. These results are consistent with the underlying hypothesis that there is an imbalance between reactive oxygen species production and the antioxidant defense system in inflammatory rheumatoid arthritis disease.

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“…Stressinduced alterations in the concentration of neurotransmitters such as excitatory amino acids, serotonin and gamma-amino-butyric acid can modulate the immune response and vice versa, and cytokines, mediators produced by immune cells, maintain homeostasis by communicating with other biological systems such as the hypothalamic-pituitary-adrenal (HPA) axis. 21,22 Recently, Kuloglu et al 23,24 recognized a link between oxidative stress and some anxiety disorders (obsessive-compulsive and panic disorder), demonstrating that oxidative metabolism can influence anxiety regulation. Bouayed et al 25 in their review summarized data which demonstrate a link between oxidative stress and anxiety, but an unambiguous cause-effect relationship has yet to be determined.…”

mentioning

confidence: 99%

Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder

et al. 2014

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Background: The aim of this study was to measure the parameters of oxidative stress in the blood of patients with post-traumatic stress disorder. Methods: The study included 80 male war veterans who participated actively in the Homeland war in Croatia. Volunteers were divided into two groups: 50 veterans diagnosed with post-traumatic stress disorder and 30 without diagnosis. The self-assessment Hospital Anxiety and Depression Scale and the Beck Depression Inventory were used to detect the severity of depression and anxiety in the post-traumatic stress disorder patients. Catalytic concentrations of superoxide dismutase and glutathione peroxidase in erythrocytes and the concentration of malondialdehyde in serum were measured spectrophotometrically. Results: Although the catalytic concentrations of erythrocyte superoxide dismutase and erythrocyte glutathione peroxidase were within the reference range for both groups, the values obtained for the post-traumatic stress disorder group were significantly lower (P < 0.001). For serum malondialdehyde concentrations, no statistically significant differences between the groups were found. Conclusions: Lower catalytic concentrations of erythrocyte superoxide dismutase and erythrocyte glutathione peroxidase in patients with post-traumatic stress disorder may indicate a weaker response to oxidative stress due to impaired enzyme activity and/or decreased synthesis. Conversely, no significant changes in serum malondialdehyde concentrations suggest a compensated balance and adaptive response to (oxidative) stress.

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Antioxidant Enzyme and Malondialdehyde Levels in Patients with Panic Disorder

Cited by 132 publications

References 15 publications

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Circulating lipid peroxidation, plasma and erythrocyte antioxidant status in patients with rheumatoid arthritis

Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder

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