Antioxidant effect of vitamin E and selenium on hepatotoxicity induced by dimethoate in female adult rats

Amara, Ibtissem Ben; Soudani, Nejla; Troudi, Afef; Bouaziz, Hanen; Boudawara, Tahia; Zeghal, Najiba

doi:10.1016/j.ecoenv.2010.11.007

Cited by 53 publications

(31 citation statements)

References 56 publications

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“…However, the co-treatment of Se plus Zn has reduced the histological alterations induced by MD, which might be attributed to their antiradical/antioxidant roles. Moreover, these results are in good accordance with those obtained by other studies which have postulated the beneficial role of Se and Zn on histopathological and enzymatic changes of rats (Goel et al, 2005;Ben Amara et al, 2010;Heikal et al, 2012). Though, the beneficial role of Se and Zn in reducing oxidative stress parameters in the present study might be related to its mild antioxidant potential against toxins induced hepatotoxicity.…”

Section: Discussionsupporting

confidence: 82%

Methidathion-induced hematological, biochemical and hepatohistological alterations in rat: Ameliorative effects of selenium and zinc

Barkat¹,

Boumendjel²,

Abdennour³

et al. 2015

Afr. J. Biotechnol.

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The aim of this study was to determine the effect of a sub-acute 4-week exposure to methidathion (MD) on the hematological system and hepatic integrity of rats. We also assessed whether co-administration of micronutrients such as selenium (Se) and zinc (Zn) prevented MD-induced hepatic damage. Rats were randomly divided into four groups of six each: the first group served as a control which received standard diet, the second group received both Se (0.5mg/kg of diet) and Zn (0.227 g/l drinking water), the third group received only MD (5 mg/kg b.w. by gavage using corn oil as a vehicle), and the fourth group received MD and combined selenium and zinc. After four weeks, exposure to MD induced a significant increase in plasmatic activities of AST, ALT, ALP, LDH, and liver malondialdehyde level. In contrast, reduced glutathione level (GSH), and the activities of catalase (CAT), superoxide dismutase (SOD), and the glutathione peroxidase (GPx) content of hepatic tissue decreased significantly. Moreover, treatment with Se and Zn in MD-treated rats maintained all the biochemical parameters cited above. In conclusion, the obtained results indicate the ability of Se and Zn to attenuate the MD-induced liver and erythrocytes oxidative damage.

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Section: Discussionsupporting

confidence: 82%

Methidathion-induced hematological, biochemical and hepatohistological alterations in rat: Ameliorative effects of selenium and zinc

Barkat¹,

Boumendjel²,

Abdennour³

et al. 2015

Afr. J. Biotechnol.

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“…It has been shown to be effective in reducing exercise-induced oxidative stress in rats (Metin et al, 2002). In addition, these findings are in good agreement with those obtained by other studies which postulated the beneficial role of vitamin E and vitamin C on histological and enzymatic changes of rats (Das et al, 2006;Ben Amara et al, 2010). Therefore, the supplementation of vitamin E or vitamin C had protected liver function from cadmium intoxication as indicated by the significant restoration of serum total protein, albumin, serum glucose, GOT, GPT and alkaline phosphatase.…”

Section: Discussionsupporting

confidence: 82%

Combined protective effect of vitamins C and E on cadmium induced oxidative liver injury in rats

Layachi¹,

Kechrid²

2012

Afr. J. Biotechnol.

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Our study pertains to the potential ability of vitamin C and/or vitamin E, used as nutritional supplements, to alleviate oxidative stress induced by cadmium. Male rats were randomly divided into five groups of eight each. Group I served as the controls; group II received in their drinking water CdCl 2 (200 mg/L); group III received both CdCl 2 and vitamin C (1.5 g/L of water); group IV was treated with CdCl 2 and vitamin E (400 mg/kg diet); and group V received CdCl 2 + vitamin C + vitamin E. The exposure of rats to cadmium chloride for 30 days resulted in a significant decrease in body weight gain. Cadmium treatment also produced oxidative liver injury characterized by increasing serum glucose concentration, glutamate-pyruvate transaminase (GPT), alanine aminotransaminase (GOT) and alkaline phosphatase (ALP) activities. Meanwhile cadmium supplementation decreased serum total protein and albumin in animals. In addition, liver glutathione level, catalase and glutathione peroxidase (GSH-Px) activities were diminished. With vitamin C and vitamin E administration during intoxication of cadmium, corrective effects on Cd-induced oxidative stress in the liver was observed. In conclusion, this study demonstrates that oral exposure to Cd caused reduction in LPO and antioxidant enzyme activities in rat's liver, and vitamin C or vitamin E may have partial ameliorative effects on these disturbances, whereas vitamin C and vitamin E together assured a more efficient protection of the organ against the noticed oxidative stress.

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“…Previous studies indicate that dimethoate leads to oxidative stress via production of free radicals and induction of lipid peroxidation [4][5][6] . Some studies have shown that dimethoate causes significant increase in lipid peroxidation by interacting with membrane lipids due to its lipophilic feature [7,8] . It has been noticed the dimethoate toxicity results in deleterious effects on various organs such as liver, brain, testes, pancreas of rats [9] .…”

Section: Introductionmentioning

confidence: 99%

Sıçanlarda Dimetoatla Oluşturulan Hepatotoksisite Üzerine Taflan (Laurocerasus officinalis Roem.) Meyvesinin Koruyucu Etkisi

Eken¹,

Endirlik²,

Baldemir³

et al. 2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleEken A, Ünlü Endirlik B, Bakır E, Baldemir A, Yay AH, Cantürk F: Effect of Laurocerasus officinalis Roem. (Cherry laurel) fruit on dimethoate induced hepatotoxicity in rats. Kafkas Univ Vet Fak Derg, 23 (5): 779-787, 2017779-787, . DOI: 10.9775/kvfd.2017 Abstract Dimethoate is one of the most important organophosphate insecticides and may cause oxidative stress leading to production of free radicals and alterations in antioxidants. The aim of this study was to investigate the protective effects of Laurocerasus officinalis Roem. fruit extract containing antioxidant compounds on dimethoate-induced hepatotoxicity in rats. The rats were divided into six groups as follows: Control group; dimethoate-treated group; L. officinalis-treated group; the group of pre-treatment with L. officinalis prior to dimethoate; the group of pre-treatment with vitamin C before dimethoate; the group of post-treatment with L. officinalis after dimethoate. Aspartate transaminase (AST), alanine transaminase (ALT), and total bilirubin (TBil) as liver function tests and the oxidative stress parameters such as total oxidant status (TOS), total antioxidant status (TAS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) were measured. The DNA damage was determined with comet assay. The results indicated that dimethoate caused a significant increase in AST, ALT, TOS, MDA, DNA damage and an important decrease in TAS, SOD, CAT, GPx as compared to control group. However, administration of L. officinalis or vitamin C to dimethoate-exposed rats restored these biochemical and oxidative stress parameters to nearly normal levels. In conclusion, toxic effects of dimethoate on rat liver are mainly attributed to hepatic function enzymes, oxidative stress and DNA damage, while these effects were largely ameliorated by L. officinalis fruit extract. Keywords: Laurocerasus officinalis Roem, Cherry Laurel, Dimethoate, Hepatotoxicity, Rat Sıçanlarda Dimetoatla Oluşturulan Hepatotoksisite Üzerine Taflan (Laurocerasus officinalis Roem.) Meyvesinin Koruyucu Etkisi ÖzetDimetoat en önemli organofosfatlı insektisitlerden biridir, serbest radikallerin üretimine ve antioksidanlarda değişimlere yol açarak oksidatif strese neden olur. Çalışmanın amacı, ratlarda antioksidan bileşikler içeren Laurocerasus officinalis Roem. meyve ekstresinin dimetoat kaynaklı karaciğer toksisitesindeki koruyucu etkilerini incelemektir. Ratlar aşağıdaki gibi altı gruba ayrıldı: Kontrol grubu; dimetoate ile muamele edilen grup; L. officinalis ile muamele edilen grup; dimetoat öncesi L. officinalis verilen grup; dimetoat öncesi vitamin C verilen grup; dimetoat sonrası L. officinalis ile muamele edilen grup. Karaciğer fonksiyon testleri olarak aspartat transaminaz (AST), alanin transaminaz (ALT) ve toplam bilirubin (TBil) ile toplam oksidan durum (TOS), toplam antioksidan durum (TAS), süperoksit dismutaz (SOD), katalaz (CAT), glutatyon peroksidaz (GPx) ve malondialdehit (MDA) gibi oksidatif stres parametreleri ölçüldü. DNA...

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Antioxidant effect of vitamin E and selenium on hepatotoxicity induced by dimethoate in female adult rats

Cited by 53 publications

References 56 publications

Methidathion-induced hematological, biochemical and hepatohistological alterations in rat: Ameliorative effects of selenium and zinc

Methidathion-induced hematological, biochemical and hepatohistological alterations in rat: Ameliorative effects of selenium and zinc

Combined protective effect of vitamins C and E on cadmium induced oxidative liver injury in rats

Sıçanlarda Dimetoatla Oluşturulan Hepatotoksisite Üzerine Taflan (Laurocerasus officinalis Roem.) Meyvesinin Koruyucu Etkisi

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