Antioxidant effect of coenzyme Q on hydrogen peroxide-activated myoglobin

Mordente, Alvaro; Martorana, Giuseppe; Santini, S A; Miggiano, Giacinto Abele Donato; Petitti, Tommasangelo; Giardina, Bruno; Battino, Maurizio; Littarru, G. P.

doi:10.1007/bf00226847

Cited by 10 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7), which suggests that the peak shift may be attributable to the reduction of CoQ 1 by CP-Pt. However, the maximum peaks we observed had a slight variance from those of oxidized and reduced CoQ 1 , as previously reported [41,42]. 6.…”

Section: Reduction Of Coq 1 By Cp-ptsupporting

confidence: 68%

Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase

Hikosaka

Kim

Kajita

et al. 2008

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Section: Reduction Of Coq 1 By Cp-ptsupporting

confidence: 68%

Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase

Hikosaka

Kim

Kajita

et al. 2008

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

“…For example, Janda et al (47) found that hydrogen peroxide inhibits sugar transport in S. pombe, indicating a direct effect of the oxidant species on membrane proteins. In this regard it is interesting that QH2 may also be involved in protein repair, as it has recently been found to be capable of reducing both ferrylmyoglobin and metmyoglobin to oxymyoglobin (49). There is evidence indicating that QH2 may protect mitochondrial proteins and DNA against oxidative damage as well (50,51).…”

Section: Discussionmentioning

confidence: 99%

Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids.

Thai

Schultz²,

Clarke³

1996

Proc. Natl. Acad. Sci. U.S.A.

150

106

View full text Add to dashboard Cite

show abstract

“…Formation of ferrylmyoglobin is an event that might have considerable practical importance, since skeletal muscle and the myocardium are rich in myoglobin, and the formation of hydrogen peroxide arising from ischemia-reperfusion might trigger myoglobin oxidation to ferrylmyoglobin, with further damage. In our experiments [27], the addition of H 2 O 2 to a metmyoglobin solution induced the rapid formation of a compound with the spectral characteristics of ferrylmyoglobin. The addition of ubiquinol 1 (we used reduced CoQ 10 because of its good water solubility) provoked a rapid and progressive reduction of ferrylmyoglobin to metmyoglobin and oxymyoglobin.…”

Section: Coenzyme Q and Reduction Of Ferrylmyoglobinmentioning

confidence: 99%

Bioenergetic and Antioxidant Properties of Coenzyme Q10: Recent Developments

2007

View full text Add to dashboard Cite

For a number of years, coenzyme Q (CoQ10 in humans) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in plasma, and extensively investigated its antioxidant role. These two functions constitute the basis on which research supporting the clinical use of CoQ10 is founded. Also at the inner mitochondrial membrane level, coenzyme Q is recognized as an obligatory co-factor for the function of uncoupling proteins and a modulator of the transition pore. Furthermore, recent data reveal that CoQ10 affects expression of genes involved in human cell signalling, metabolism, and transport and some of the effects of exogenously administered CoQ10 may be due to this property. Coenzyme Q is the only lipid soluble antioxidant synthesized endogenously. In its reduced form, CoQH2, ubiquinol, inhibits protein and DNA oxidation but it is the effect on lipid peroxidation that has been most deeply studied. Ubiquinol inhibits the peroxidation of cell membrane lipids and also that of lipoprotein lipids present in the circulation. Dietary supplementation with CoQ10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoproteins to the initiation of lipid peroxidation. Moreover, CoQ10 has a direct anti-atherogenic effect, which has been demonstrated in apolipoprotein E-deficient mice fed with a high-fat diet. In this model, supplementation with CoQ10 at pharmacological doses was capable of decreasing the absolute concentration of lipid hydroperoxides in atherosclerotic lesions and of minimizing the size of atherosclerotic lesions in the whole aorta. Whether these protective effects are only due to the antioxidant properties of coenzyme Q remains to be established; recent data point out that CoQ10 could have a direct effect on endothelial function. In patients with stable moderate CHF, oral CoQ10 supplementation was shown to ameliorate cardiac contractility and endothelial dysfunction. Recent data from our laboratory showed a strong correlation between endothelium bound extra cellular SOD (ecSOD) and flow-dependent endothelial-mediated dilation, a functional parameter commonly used as a biomarker of vascular function. The study also highlighted that supplementation with CoQ10 that significantly affects endothelium-bound ecSOD activity. Furthermore, we showed a significant correlation between increase in endothelial bound ecSOD activity and improvement in FMD after CoQ10 supplementation. The effect was more pronounced in patients with low basal values of ecSOD. Finally, we summarize the findings, also from our laboratory, on the implications of CoQ10 in seminal fluid integrity and sperm cell motility.

show abstract

Antioxidant effect of coenzyme Q on hydrogen peroxide-activated myoglobin

Cited by 10 publications

References 16 publications

Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase

Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase

Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids.

Bioenergetic and Antioxidant Properties of Coenzyme Q10: Recent Developments

Contact Info

Product

Resources

About