Antioxidant Effect of Aqueous Extract of Curcuma longa Rhizomes (Zingiberaceae) in the Typhoid Fever Induced in Wistar Rats Model

Kodjio, Norbert; Atsafack, Serge Secco; Njateng, Guy Sedar Singor; Sokoudjou, Jean Baptiste; Kuiaté, Jules Roger; Gatsing, Donatien

doi:10.9734/jamps/2016/24949

Cited by 23 publications

(30 citation statements)

References 19 publications

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“…Plants with high anti-salmonellal potential that show promise for the control of avian salmonellosis include Aloe secundiflora [ 47 ], Thymus vulgaris [ 48 ], Curcuma longa and Scutellaria baicalensis [ 25 ] and Erica mannii [ 27 ]. Plant extracts as well as traditionally improved drugs are one of the promising ways to combat human salmonellosis [ 23 , 47 , 49 ]. Several authors [ 22 , 23 , 28 , 50 – 53 ] have shown that plant extracts depending on their concentrations are active both in vitro and in vivo against several Salmonella serotypes.…”

Section: Discussionmentioning

confidence: 99%

“…The large majority of salmonellosis in humans is carried by foodstuffs; mainly those of avian origin [10,20,21], therefore controlling avian salmonellosis by using plant could significantly reduce the prevalence of human gastroenteritis [20]. Several studies have focused on medicinal plants as new control strategies for human salmonellosis [22,23] or avian salmonellosis [24][25][26][27][28]. But, to our knowledge, no phytomedicine has yet been formulated to control avian salmonellosis.…”

Section: Introductionmentioning

confidence: 99%

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Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Sokoudjou

Atolanı

Njateng

et al. 2020

BMC Complement Med Ther

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Background Bacteria belonging to the Salmonella genus are major concern for health, as they are widely reported in many cases of food poisoning. The use of antibiotics remains a main stream control strategy for avian salmonellosis as well as typhoid and paratyphoid fevers in humans. Due to the growing awareness about drug resistance and toxicities, the use of antibiotics is being discouraged in many countries whilst advocating potent benign alternatives such as phyto-based medicine. The objective of this work was to isolate, characterise the bioactive compounds of Canarium schweinfurthii; and evaluate their anti-salmonellal activity. Methods The hydro-ethanolic extract of Canarium schweinfurthii was fractionated and tested for their anti-salmonellal activity. The most active fractions (i.e. chloroform and ethyl acetate partition fractions) were then explored for their phytochemical constituents. Fractionation on normal phase silica gel column chromatography and size exclusion chromatography on Sephadex LH-20 led to the isolation of four compounds (maniladiol, scopoletin, ethyl gallate and gallic acid) reported for the first time in Canarium schweinfurthii. Results Result indicated that scopoletin and gallic acid had greater activity than the crude extracts and partition fractions. Among the isolated compounds, scopoletin showed the highest inhibitory activity with a MIC of 16 μg/ml against Salmonella Typhimurium and Salmonella Enteritidis. Conclusions The overall results of this study indicates that the hydro-ethanolic extract as well as some of isolated compounds have interesting anti-salmonellal activities that could be further explored for the development of potent therapy for salmonellosis. Furthermore, the study adds credence to the folkloric applications of the plant.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Sokoudjou

Atolanı

Njateng

et al. 2020

BMC Complement Med Ther

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“…Curcumin may have anti-inflammatory and anticancer activities to prevent and treat the disease. (Kodjio et al, 2016) studied revealed that aqueous extract from Curcuma longa rhizomes has antityphoid and antioxidant activities. Based on the previous review, more attention should be paid to the protective effects of natural antioxidants against chemically induced toxicities.…”

Section: Introductionmentioning

confidence: 99%

Potential therapeutic effect of turmeric (Curcuma longa) against adverse effects of penconazole fungicide to white rats

Rasoul

Marei

2016

IJPT

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This study aimed to investigate the prophylactic effect of turmeric (Curcuma longa) Rhizome Ethanolic extract (CLRE) at 250 mg/kg as antioxidant effects against penconazole induced sub-acute toxicity. Hepatic, renal and testicular pathological changes caused by oxidative damage induced by penconazole in rats were biochemically and histologically evaluated. Male rats were treated with penconazole, via oral route, at doses of 0.5 mg/ kg body weight (b.w.; acute reference dose, ARfD), 25 mg/kg b.w. (no observed adverse effects level, NOAEL) and 100 mg/ kg b.w. (1/20 lethal dose [LD 50 ]) for 28 consecutive days. Penconazole treatments had significant (p < 0.05) and gradual reductions in body and relative testicular weight accompanied by significant elevation in the relative liver and kidney weights. Significant increase serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dhydrogenase(LDH), gamma-glutamyl transferase (GGT), creatinine (Cre), uric acid and blood glucose was observed due to penconazole treatments. However, total protein and testosterone hormone were significantly decreased. Exposure to penconazole caused increase in lipid peroxidation (LPO) and decreased of liver and kidney antioxidant enzymes activity as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx). Histopathological studies confirmed the ameliorative beneficial effects of turmeric biochemical parameters. On the basis of this study, the use of tumeric rhizomes as a functional food or as a nutraceutical product could be a useful approach to protect individuals who are regularly exposed to penconazole.

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“…Malondialdehyde (MDA) concentration was determined by the thiobarbituric acid method (15), while the superoxide dismustase activity was evaluated according to Dimo et al (16) method. The catalase (CAT) activity was assessed using the chromic acetate method (17), and glutathione peroxidase (GPx) activity was determined by the potassium iodate method (18).…”

Section: Evaluation Of Oxidative Stressmentioning

confidence: 99%

Heat Induces Oxidative Stress: Reproductive Organ Weights and Serum Metabolite Profile, Testes Structure, and Function Impairment in Male Cavy (Cavia porcellus)

et al. 2020

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Antioxidant Effect of Aqueous Extract of Curcuma longa Rhizomes (Zingiberaceae) in the Typhoid Fever Induced in Wistar Rats Model

Cited by 23 publications

References 19 publications

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Potential therapeutic effect of turmeric (Curcuma longa) against adverse effects of penconazole fungicide to white rats

Heat Induces Oxidative Stress: Reproductive Organ Weights and Serum Metabolite Profile, Testes Structure, and Function Impairment in Male Cavy (Cavia porcellus)

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