Antioxidant compounds of <i>Petasites japonicus</i> and their preventive effects in chronic diseases: a review

Abstract

Petasites japonicus ( P. japonicus ) is a plant of the Asteraceae family. Its roots and stems have been used for the treatment or the prophylaxis of migraine and tension headache as a traditional Chinese medicine in Japan and Korea. Sesquiterpenoids, lignans, and flavonoids are components of P. japonicus . Regarding the biological activity of P. japonicus , its anti-allergic effect has been researched extensively using IgE antigen-stimulated degranulation of RBL-2H3 cells or passive cutaneous anaphylaxis reaction in experimental animal models. The study of the antioxidant activity of P. japonicus was initiated approximately 15 years ago using in vitro assays. In addition, its in vivo effect has also been examined in animal models with induced oxidative injury. Moreover, recently, many types of antioxidant compounds have been rapidly and simultaneously identified using the liquid chromatography–mass spectrometry technique. The number of reports on the other functions of this plant, such as its neuroprotective and anti-inflammatory effects, has been increasing. In this review, I summarized the studies of functional foods derived from P. japonicus , which may provide a basis for the development of potential functional foods. Finally, I discuss the future research avenues in this field.

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

“…It is commonly known that, some Western traditional medicine herbs, such as butterbur ( Petasites hybridus ), feverfew ( Tanacetum parthenium L.) and rosemary ( Rosmarinus officinalis L.) are evidenced beneficial for migraine ( Ghasemzadeh Rahbardar and Hosseinzadeh, 2020 ; Hiemori-Kondo, 2020 ; Darbahani et al, 2022 ; Kulinowski et al, 2022 ). However, they were not identified by this Chinese medicine classical literature data-mining research.…”

Petasites for Migraine Prevention: New Data on Mode of Action, Pharmacology and Safety. A Narrative Review

“…In a recent review the antioxidant compounds obtained from leaves and flower buds of Petasites japonicus were summarized ( 53 ), and the following constituents with proven antioxidant activity were identified: Quercetin 3-O-β-d-glucoside, quercetin 3-O-β-d-6”-O-acetylglucoside, rutin, caffeic acid, petasiformin A, petaslignolide A, chlorogenic acid, fukinolic acid, 3,5-dicaffeoyl quinic acid, 3,4,5-tricaffeoyl quinic acid and the flavonol kaempferol. Similarly, the chemical analysis of a methanol extract of leaves and roots of Petasites japonicus identified 5-caffeoylquinic acid, fukinolic acid, 3,5-di-O-caffeoylquinic acid, quercetin-3-O-(6”-acetyl)-β-glucopyranoside, 4,5-di-O-caffeoylquinic acid and kaempferol-3-O-(6”-acetyl)-β-glucopyranoside as antioxidants.…”

Petasites japonicus leaf extract inhibits Alzheimer's-like pathology through suppression of neuroinflammation

“…is an herbal plant of the Asteraceae family and called butterbur. 11,12 P. japonicus is widely distributed in the East-Asia countries such as Korea and Japan. 12 Studies have found that P. japonicus has multiple beneficial effects such as tumor suppression 13 and amelioration of immune disorders.…”