<i>Petasites japonicus</i> leaf extract inhibits Alzheimer's-like pathology through suppression of neuroinflammation

Eo, Hyeyoon; Lee, Seungmin; Kim, Seong Hye; Ju, In Gyoung; Huh, Eugene; Lim, Jeongin; Park, Sangsu; Oh, Myung Sook

doi:10.1039/d2fo01989b

Cited by 7 publications

(1 citation statement)

References 54 publications

(77 reference statements)

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“…The Y-maze test was performed using a Y-shaped maze consisting of three arms (40 cm × 3 cm × 12 cm walls) to assess working memory [ 25 ]. The mouse was placed in the center of the Y-maze and allowed to explore each arm labeled A, B, or C. Arm entries and sequences were recorded for 8 min.…”

Section: Methodsmentioning

confidence: 99%

Rhei Undulati Rhizoma attenuates memory decline and reduces amyloid-β induced neuritic dystrophy in 5xFAD mouse

Lee,

Ju,

et al. 2024

Chin Med

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Background Alzheimer's disease (AD) is a common type of dementia characterized by amyloid-β (Aβ) accumulation, lysosomal dysfunction, and tau hyperphosphorylation, leading to neurite dystrophy and memory loss. This study aimed to investigate whether Rhei Undulati Rhizoma (RUR), which has been reported to have anti-neuroinflammatory effect, attenuates Aβ-induced memory impairment, neuritic dystrophy, and tau hyperphosphorylation, and to reveal its mode of action. Methods Five-month-old 5xFAD mice received RUR (50 mg/kg) orally for 2 months. The Y-maze test was used to assess working memory. After behavioral testing, brain tissue was analyzed using thioflavin S staining, western blotting, and immunofluorescence staining to investigate the mode of action of RUR. To confirm whether RUR directly reduces Aβ aggregation, a thioflavin T assay and dot blot were performed after incubating Aβ with RUR. Results RUR administration attenuated the Aβ-induced memory impairment in 5xFAD mice. Furthermore, decreased accumulation of Aβ was observed in the hippocampus of the RUR-treated 5xFAD group compare to the vehicle-treated 5xFAD group. Moreover, RUR reduced the dystrophic neurites (DNs) that accumulate impaired endolysosomal organelles around Aβ. In particular, RUR treatment downregulated the expression of β-site amyloid precursor protein cleaving enzyme 1 and the hyperphosphorylation of tau within DNs. Additionally, RUR directly suppressed the aggregation of Aβ, and eliminated Aβ oligomers in vitro. Conclusions This study showed that RUR could attenuate Aβ-induced pathology and directly regulate the aggregation of Aβ. These results suggest that RUR could be an efficient material for AD treatment through Aβ regulation. Graphical Abstract

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Section: Methodsmentioning

confidence: 99%

Rhei Undulati Rhizoma attenuates memory decline and reduces amyloid-β induced neuritic dystrophy in 5xFAD mouse

Lee,

Ju,

et al. 2024

Chin Med

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Linderae Radix Ameliorates Cognitive Dysfunction by Inhibiting Neuroinflammation and Synaptic Damage in Alzheimer’s Disease Models

Kim

et al. 2023

Mol Neurobiol

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An electrochemical sensing platform based on gold nanostars for the detection of Alzheimer's disease marker Aβ oligomers (Aβo)

Wang,

Chen,

Guan

et al. 2023

Alexandria Engineering Journal

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Petasites japonicus leaf extract inhibits Alzheimer's-like pathology through suppression of neuroinflammation

Abstract: Neuroinflammation is a crucial step involved in development and progression of Alzheimer's disease. The current study found that Petasites japonicus leaf extract inhibits neuroinflammation induced by lipopolysaccharides and amyloid beta oligomers.

Cited by 7 publications

References 54 publications

Rhei Undulati Rhizoma attenuates memory decline and reduces amyloid-β induced neuritic dystrophy in 5xFAD mouse

Rhei Undulati Rhizoma attenuates memory decline and reduces amyloid-β induced neuritic dystrophy in 5xFAD mouse

Linderae Radix Ameliorates Cognitive Dysfunction by Inhibiting Neuroinflammation and Synaptic Damage in Alzheimer’s Disease Models

An electrochemical sensing platform based on gold nanostars for the detection of Alzheimer's disease marker Aβ oligomers (Aβo)

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