Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

Abstract

Background: Treatment effect of current pharmacotherapies for migraine is unsatisfying. Discovering new anti-migraine natural products and nutraceuticals from large collections of Chinese medicine classical literature may assist to address this gap.Methods: We conducted a comprehensive search in the Encyclopedia of Traditional Chinese Medicine (version 5.0) to obtain migraine-related citations, then screened and scored these citations to identify clinical management of migraine using oral herbal medicine in history. Information of formulae, herbs and symptoms were further extracted. After standardisation, these data were analysed using frequency analysis and the Apriori algorithm. Anti-migraine effects and mechanisms of actions of the main herbs and formula were summarised.Results: Among 614 eligible citations, the most frequently used formula was chuan xiong cha tiao san (CXCTS), and the most frequently used herb was chuan xiong. Dietary medicinal herbs including gan cao, bai zhi, bo he, tian ma and sheng jiang were identified. Strong associations were constructed among the herb ingredients of CXCTS formula. Symptoms of chronic duration and unilateral headache were closely related with herbs of chuan xiong, gan cao, fang feng, qiang huo and cha. Symptoms of vomiting and nausea were specifically related to herbs of sheng jiang and ban xia.Conclusion: The herb ingredients of CXCTS which presented anti-migraine effects with reliable evidence of anti-migraine actions can be selected as potential drug discovery candidates, while dietary medicinal herbs including sheng jiang, bo he, cha, bai zhi, tian ma, and gan cao can be further explored as nutraceuticals for migraine.

Real-world observations and impacts of Chinese herbal medicine for migraine: results of a registry-based cohort study

“…The frequency analysis indicated that herbs gan cao , gui zhi , chuan xiong , fu ling , bai zhu , yan hu suo , ban xia , chen pi , bai shao and xiang fu , were widely utilised for migraine, which is similar to the findings of our previous research ( Lyu et al, 2020 ; Lyu et al, 2022a ; Lyu et al, 2022b ; Zhang et al, 2022 ). These herbs were reported to exhibit anti-migraine, anti-depression, neuroprotective, sedative-hypnotic and/or antiemetic actions, as summarised in Table 8 .…”

Toward Enhanced Customer Transaction Insights: An Apriori Algorithm-based Analysis of Sales Patterns at University Industrial Corporation

“…Educational research has surfaced various funding initiatives. Among these are studies analyzing user behavior when requesting texts from the library loans [38], uncovering natural products and antimigraine nutraceuticals from extensive classical medical literature collections [39], and rule extraction from the scoring records of 2002 computer science students at the Mongolian University of Science and Technology [40].…”