Antioxidant capacity of hesperidin from<i>Citrus</i>peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines

Al-Ashaal, Hanan A.; Sheltawy, S. T. El

doi:10.3109/13880209.2010.509734

Cited by 92 publications

(46 citation statements)

References 29 publications

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“…The anticancer potential of hesperidin has been demonstrated by inhibiting cancer cell growth and proliferation via apoptosis induction in different cancer cell lines of breast (MCF‐7), larynx (HEp‐2), cervix (HeLa), and liver (HpG‐2) . However, the effects of hesperidin in liver cancer cells have not been investigated so far.…”

Section: Discussionmentioning

confidence: 99%

Demethylating and anti‐hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices

Fernández-Bedmar

Anter

Alonso-Moraga

et al. 2017

Molecular Carcinogenesis

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Hepatocellular carcinoma (HCC) is a neoplasia representing the fifth most common malignancy worldwide and the third cause of death from cancer. Diets with high content in fruits and vegetables are widely recommended for their health-promoting properties, among them, the protection against diabetes, cancer, and cardiovascular diseases. Hesperidin is the most important phenol in the orange fruit with well-known health benefits. Diet components have been used as possible modulator agents of DNA methylation in cancer cells and epigenetic therapy against their harmful effects could be a potential tool in chemotherapy. The purpose of the present study was to evaluate the methylation patterns induced by hesperidin in HL60 cell line as an in vitro model in order to analyze its chemopreventive effects in epigenetic cancer therapies. A parallel in vivo pilot experience using a rat diethyl nitrosamine hepatocarcinogenesis-induced model was carried out to validate the therapeutic efficacy of this orange flavonol. Results showed that: (i) Hesperidin is cytotoxic in a dose-dependent manner and the IC was 12.5 mM; (ii) Hesperidin exerts a significant hypomethylating effect on the LINE-1 sequence (up to 47% hypomethylation at 12.5 mM) and on the ALU-M2 repetitive sequences (up to 32% at 6 mM) in HL60 tumor cells. (iii) Hesperidin does not affect the rat body and liver weight and it is able to reduce the diethyl nitrosamine-induced nodules at 1,000, 500, and 250 ppm. In conclusion, hesperidin could be proposed as a candidate molecule in chemoprevention in epigenetic therapy purposes.

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Section: Discussionmentioning

confidence: 99%

Demethylating and anti‐hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices

Fernández-Bedmar

Anter

Alonso-Moraga

et al. 2017

Molecular Carcinogenesis

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“…It is known to have various physiological functions. Laboratory research showed that it has antiinflammatory effects and anticancer activity (Galati et al ., ; Al‐Ashaal and El‐Sheltawy, ). Moreover, hesperidin has been shown to reduce cholesterol levels and blood pressure and to inhibit bone loss in animal studies (Chiba et al ., ; Ohtsuki et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Gelidium elegans, an Edible Red Seaweed, and Hesperidin Inhibit Lipid Accumulation and Production of Reactive Oxygen Species and Reactive Nitrogen Species in 3T3‐L1 and RAW264.7 Cells

Jeon

Seo

Choi

et al. 2014

Phytotherapy Research

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Gelidium elegans is an edible red alga native to the intertidal area of northeastern Asia. We investigated the effect of G. elegans extract and its main flavonoids, rutin and hesperidin, on lipid accumulation and the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in 3T3-L1 and RAW264.7 cells. Our data show that G. elegans extract decreased lipid accumulation and ROS/RNS production in a dose-dependent manner. The extract also inhibited the mRNA expression of adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding protein alpha, while enhancing the protein expression of the antioxidant enzymes superoxide dismutases 1 and 2, glutathione peroxidase, and glutathione reductase compared with controls. In addition, lipopolysaccharide-induced nitric oxide production was significantly reduced in G. elegans extract-treated RAW264.7 cells. In analysis of the effects of G. elegans flavonoids on lipid accumulation and ROS/RNS production, only hesperidin showed an inhibitory effect on lipid accumulation and ROS production; rutin did not affect adipogenesis and ROS status. The antiadipogenic effect of hesperidin was evidenced by the downregulation of peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein alpha, and fatty acid binding protein 4 gene expression. Collectively, our data suggest that G. elegans is a potential food source containing antiobesity and antioxidant constituents.

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“…In the present study, we demonstrate here that topical hesperidin treatment accelerates epidermal permeability barrier homeostasis and stimulates epidermal proliferation and differentiation in normal murine skin. Although all of the exact underlying mechanisms for improvements are not clear, these improvements could be partially attributed to hesperidin antioxidant properties (33–35), which were not assessed here. Pertinently, other antioxidant, such as vitamin E, elevates transglutaminase‐1 expression and increases PPAR activity and expression in keratinocyte cultures (36).…”

Section: Discussionmentioning

confidence: 99%

Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin

Hou

Man

et al. 2012

Experimental Dermatology

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Orange peel extract appears to exhibit beneficial effects on skin whitening, inflammation, UVB protection, as well as keratinocyte proliferation. In the present study, we determine whether topical hesperidin influences epidermal permeability barrier function and its underlying mechanisms. Hairless mice were treated topically with 2% hesperidin or 70% ethanol alone twice daily for 6 days. At the end of treatment, basal barrier function as well as transepidermal water loss (TEWL) was measured 2 and 4 hours post barrier disruption. Epidermal proliferation and differentiation were evaluated by immunohistochemical staining and Western blot analysis. Additionally, lamellar body density and secretion were assessed by electron microscopy. Although there were no significant differences in basal barrier function, in comparison to control animals, topical hesperidin significantly accelerated barrier recovery at both 2 and 4 hours after acute barrier abrogation. Enhanced barrier function in hesperidin-treated skin correlated with stimulation of both epidermal proliferation and differentiation, as well as enhanced lamellar body secretion. These results indicate that topical hesperidin enhances epidermal permeability barrier homeostasis at least in part due to stimulation of epidermal proliferation, differentiation, as well as lamellar body secretion.

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Antioxidant capacity of hesperidin fromCitruspeel using electron spin resonance and cytotoxic activity against human carcinoma cell lines

Cited by 92 publications

References 29 publications

Demethylating and anti‐hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices

Demethylating and anti‐hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices

Gelidium elegans, an Edible Red Seaweed, and Hesperidin Inhibit Lipid Accumulation and Production of Reactive Oxygen Species and Reactive Nitrogen Species in 3T3‐L1 and RAW264.7 Cells

Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin

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