Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review

Abstract

Natural-based biomaterials play an important role in developing new products for medical applications, primarily in cutaneous injuries. A large panel of biomaterials with antioxidant properties has revealed an advancement in supporting and expediting tissue regeneration. However, their low bioavailability in preventing cellular oxidative stress through the delivery system limits their therapeutic activity at the injury site. The integration of antioxidant compounds in the implanted biomaterial should be able to maintain their antioxidant activity while facilitating skin tissue recovery. This review summarizes the recent literature that reported the role of natural antioxidant-incorporated biomaterials in promoting skin wound healing and tissue regeneration, which is supported by evidence from in vitro, in vivo, and clinical studies. Antioxidant-based therapies for wound healing have shown promising evidence in numerous animal studies, even though clinical studies remain very limited. We also described the underlying mechanism of reactive oxygen species (ROS) generation and provided a comprehensive review of ROS-scavenging biomaterials found in the literature in the last six years. Furthermore, other potential applications of antioxidant biomaterials in the biomedical and industrial fields are also described.

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

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Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine

“…The integration of natural-based antioxidant compounds in the implanted biomaterial has revealed an advancement in supporting and expediting tissue regeneration where the scaffolds should be able to maintain their antioxidant activity while facilitating skin tissue recovery. Fadilah et al reviewed the antioxidant-based therapies by summarised the recent literature that reported the role of natural antioxidant-incorporated biomaterials in promoting skin wound healing and tissue regeneration ( Fadilah et al, 2023 ). For future directions on antioxidant therapy, earlier intervention seems to have a higher chance of success.…”

Nanofibrous scaffolds for the healing of the fibrocartilaginous enthesis: advances and prospects

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