Nanofibrous scaffolds for the healing of the fibrocartilaginous enthesis: advances and prospects

Li, Xin; Ren, Yan; Xue, Yueguang; Zhang, Yiming; Liu, Ying

doi:10.1039/d3nh00212h

Cited by 3 publications

(1 citation statement)

References 171 publications

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“…111,112 Typically, nanofiber matrices are widely used in engineering linear tissues, such as nerves and muscles, due to their orientational guidance and capacity to endow cells with topical stimuli-responsiveness. 113 Girao et al introduced size- and O group-controllable GO-laden gel and polycaprolactone (PCL) composite nanofiber matrices (rGO-PCL/gel) to induce the neurogenic differentiation of embryonic neural progenitor cells (ENMCs). 110 The rGO-PCL/gel scaffolds maintained their structural integrity and displayed distinct mechanical properties, with excellent compressive moduli.…”

Section: Tissue Regeneration Using Mxenes and Xenes: Comparison With ...mentioning

confidence: 99%

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

Kang,

Jang,

et al. 2024

Nanoscale Horiz.

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Section: Tissue Regeneration Using Mxenes and Xenes: Comparison With ...mentioning

confidence: 99%

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

Kang,

Jang,

et al. 2024

Nanoscale Horiz.

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Multifunctional nanofibrous scaffolds for enhancing full-thickness wound healing loaded with Bletilla striata polysaccharides

Zhao,

Huang,

Tang

et al. 2024

International Journal of Biological Macromolecules

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Revealing the Auxetic Behavior of Biomimetic Multi-material and Region-specific Nanofibrous Scaffolds via Synchrotron Multiscale Digital Volume Correlation: Innovative Building Blocks for the Enthesis Regeneration

Sensini,

Giacomini,

Stamati

et al. 2024

Preprint

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Enthesis lesions are one of the prevalent causes of injuries in the tendon tissue. The gradient of mineralization, extracellular matrix organization and auxetic mechanical properties, make enthesis regeneration challenging. Innovative electrospun fascicle-inspired nanofibrous poly(L-lactic)acid/collagen type I blend scaffolds were developed. Specifically, a mineralized fibrocartilage-inspired region (with/without nano-mineralization with hydroxyapatite), where random and aligned nanofibers coexist, is connected to a tendon-like region made of aligned nanofibers, through a conical non-mineralized fibrocartilage-inspired junction. Scanning electron microscopy and synchrotron nano-tomography show the morphological biomimicry of scaffolds with the natural tendon fascicles. Human mesenchymal stromal cells spheroids cultures confirm a balanced expression of both tendon, cartilage and bone markers on the non- mineralized scaffolds compared with the mineralized ones. Mechanical tests, at different physiological strain-rates, reveal a biomimetic mechanical behavior of scaffolds and the ability of junctions to tune the mechanics of their surrounding sites. Multiscale synchrotron in situ tensile tests, coupled with Digital Volume Correlation, elucidate the full-field strain distribution of scaffolds from the structural down to the nanofiber level, highlighting the auxetic mechanical behavior of junctions typical of the natural enthesis. The findings and cutting-edge investigations of our study suggest the suitability of these enthesis-inspired fascicles as innovative scaffolds for enhanced enthesis regeneration.

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Nanofibrous scaffolds for the healing of the fibrocartilaginous enthesis: advances and prospects

Abstract: With the current developmental advancements in nanotechnology, nanofibrous scaffolds are being widely used. The healing of fibrocartilaginous enthesis is a slow and complex process, and while existing treatments have a...

Cited by 3 publications

References 171 publications

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

Multifunctional nanofibrous scaffolds for enhancing full-thickness wound healing loaded with Bletilla striata polysaccharides

Revealing the Auxetic Behavior of Biomimetic Multi-material and Region-specific Nanofibrous Scaffolds via Synchrotron Multiscale Digital Volume Correlation: Innovative Building Blocks for the Enthesis Regeneration

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