Antioxidant attenuation of atrazine induced histopathological changes in testicular tissue of goat in vitro

Sharma, RK; Fulia, A.; Chauhan, Priyanka

doi:10.4103/0971-6580.103665

Cited by 8 publications

(8 citation statements)

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“…The metabolism of ATZ interferes with oxidative phosphorylation and cytochrome P450 function, resulting in decreased oxygen consumption [ 10 , 14 , 39 , 47 ]. ATZ is known to alter reproductive processes in rodents [ 96 , 101 ], reptiles [ 18 ], birds [ 104 ], goats [ 81 ], amphibians [ 28 – 30 ] and fish [ 63 , 69 ]. ATZ targets many tissues, including the testes [ 67 , 68 , 101 ], ovaries [ 8 , 17 , 41 , 52 ], brain [ 5 , 7 ], liver [ 25 , 36 , 38 , 78 ].…”

Section: Introductionmentioning

confidence: 99%

The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine

et al. 2015

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BackgroundEnvironmental factors such as pesticides can cause phenotypic changes in various organisms, including mammals. We studied the effects of the widely used herbicide atrazine (ATZ) on meiosis, a key step of gametogenesis, in male mice.MethodsGene expression pattern was analysed by Gene–Chip array. Genome-wide mapping of H3K4me3 marks distribution was done by ChIP-sequencing of testis tissue using Illumina technologies. RT-qPCR was used to validate differentially expressed genes or differential peaks.ResultsWe demonstrate that exposure to ATZ reduces testosterone levels and the number of spermatozoa in the epididymis and delays meiosis. Using Gene-Chip and ChIP-Seq analysis of H3K4me3 marks, we found that a broad range of cellular functions, including GTPase activity, mitochondrial function and steroid-hormone metabolism, are affected by ATZ. Furthermore, treated mice display enriched histone H3K4me3 marks in regions of strong recombination (double-strand break sites), within very large genes and reduced marks in the pseudoautosomal region of X chromosome.ConclusionsOur data demonstrate that atrazine exposure interferes with normal meiosis, which affects spermatozoa production.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-015-2095-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine

et al. 2015

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“…A number of toxicological studies have shown that fertilizers and pesticides like organochlorides, organophosphates etc. tremendously (GOI, 2007;2012). (GOI, 2007;2012).…”

Section: Factors Responsible For Declining Goat Population Fertilizermentioning

confidence: 99%

“…tremendously (GOI, 2007;2012). (GOI, 2007;2012). affecting the goat reproductive parameters which leads to drastically decline in their population and economy of the country GOI (2012).…”

Section: Factors Responsible For Declining Goat Population Fertilizermentioning

confidence: 99%

“…The normal functional morphology of testis, epididymis, vasa efferentia, ovaries, oviducal segments and uterine tube have been found to be altered Bhardwaj and Sharma (2011); Sharma et al, (2013). Pesticides like Endosulphan induce changes in goat spermatogonia histomorphology like chromolysis, cytoplasm shrinkage Sharma et al, (2010) Malathione leads to apoptosis in granulosa cell Bhardwaj and Saraf, (2016b); Sharma and Bhardwaj (2007) and Atrazine Sharma et al, (2012) in last decade.…”

Section: Factors Responsible For Declining Goat Population Fertilizermentioning

confidence: 99%

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Current status and changing national scenario of goat population: A review

Bhardwaj¹,

Kumar²,

Saraf³

et al. 2018

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Goats have been associated with man since dawn of agriculture and domestication of animals, making them socioeconomically, a very important animal providing products (meat, milk, fibre, hair ) and service to man throughout the world, especially in developing countries. In India, the total numbers of goat breeds that have been recognized till date is 26 and most other still remain unexplored. According to 19th livestock census a sharp decline in goat population was found over the previous census, suggesting the need of sustainable management for preserving goat breeds and population. A number of factors are found to be responsible for this continues decline in goat population. Efforts have been made through different conservation planning in different region of India. The present review focuses on the current status of goat population in India and its states that stresses out the necessities to protect this species for our own benefits.

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“…Vitamin therapy is also playing nowadays a decisive role in attenuating the oxidative stress caused by various endocrine disruptors e.g. vitamin E to ameliorate atrazine-induced oxidative stress in liver 27 and testicular tissue 28 . Quercetin, a natural flavanoid found to exhibit significant protection of sertoli germ cells against atrazine-induced oxidative damage 29 .…”

Section: Introductionmentioning

confidence: 99%

Effective attenuation of atrazine-induced histopathological changes in testicular tissue by antioxidantN-phenyl-4-aryl-polyhydroquinolines

Chandak¹,

Bhardwaj

Zheleva‐Dimitrova

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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Some of the environmental toxicants acting as endocrine disruptors have been associated with health hazards in human and wildlife by modulating hormonal actions. Atrazine, a strong endocrine disruptor, induces detrimental effects on gonads in male and female, and causes impairment of fertility and developmental problems as well as sex alterations. Atrazine decreases the activities of antioxidant enzymes and thus responsible for oxidative stress. Natural antioxidants have shown ability to reduce/slow down the apoptotic effect of atrazine on testicular tissue. In the present study, some N-phenyl-4-aryl-polyhydroquinolines bearing phenolic or/and alkoxy group(s) (6a-6g) were synthesized and evaluated for antioxidant activity in four different assays. Three best compounds (6e-6g) were studied for their ameliorative effect on testicular tissue supplemented with atrazine in vitro.

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Antioxidant attenuation of atrazine induced histopathological changes in testicular tissue of goat in vitro

Cited by 8 publications

References 19 publications

The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine

The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine

Current status and changing national scenario of goat population: A review

Effective attenuation of atrazine-induced histopathological changes in testicular tissue by antioxidantN-phenyl-4-aryl-polyhydroquinolines

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