Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities of<i>Hyoscyamus reticulatus</i>

Mohammad, Mohammad K.; Almasri, Ihab M.; Tawaha, Khaled; Issa, Ala; Al-Nadaf, Afaf H.; Hudaib, Mohammad; AlKhatib, Hatim S.; Abu‐Gharbieh, Eman; Bustanji, Yasser

doi:10.3109/13880209.2010.483521

Cited by 27 publications

(18 citation statements)

References 45 publications

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“…According to these studies, seeds of H. niger have been used for toothache, inflamed wounds, pain and itching in eyes and ears. As observed by Mohammad et al . (2010), H. reticulatus aqueous extract showed strong antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities.…”

Section: Resultssupporting

confidence: 76%

“…Due to above-mentioned pharmacological importance of Hyoscyamus species, it is worthwhile to determine antioxidant properties and fatty acid composition of H. reticulatus. However, there are a few reports on the antioxidant properties and fatty acid profile of Hyoscyamus species (Ramadan et al 2007;Ebrahimzadeh et al 2009a,b;Mohammad et al 2010). The objective of this work was to obtain information about the antioxidant properties and fatty acid composition of H. reticulatus.…”

Section: Introductionmentioning

confidence: 97%

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STUDIES ON ANTIOXIDANT PROPERTIES OF THE DIFFERENT SOLVENT EXTRACTS AND FATTY ACID COMPOSITION OFHYOSCYAMUS RETICULATUSL.

Güler

2011

Journal of Food Biochemistry

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Hyoscyamus reticulatus (Solanaceae) is distributed in the Mediterranean, East and Central Anatolia regions of Turkey. In the present study, antioxidant properties of the various extracts of H. reticulatus were evaluated by seven different chemical assays, namely total phenolics and flavonoids content, total antioxidant capacity, free radical (2,2‐diphenyl‐1‐picrylhydrazyl)‐scavenging assay, β‐carotene/linoleic acid test system, and ferric‐ and cupric ion‐reducing power. The strongest antioxidant properties were obtained by ethanolic extract. The order of the antioxidant properties of extracts were ethanolic > methanolic > acetone. Fatty acid composition of the aerial parts of H. reticulatus was analyzed by gas chromatography. The main fatty acids of the oil gave the proportions C 12:0 (lauric acid), C 10:0 (capric acid) and C 11:0 (undecanoic acid). Results of the present study demonstrated that the extracts and oil of H. reticulatus may be used as a source of natural antioxidant and lauric acid in the food and pharmaceutical industries. PRACTICAL APPLICATIONS Hyoscyamus species contain important tropane alkaloids, which have antispasmodic, anticholinergic, analgesic and sedative effects. In this study, antioxidant properties of the various extracts of Hyoscyamus reticulatus were investigated by seven different chemical assays. The results of the present study may be important as an indication of pharmacological and food processing utility of the plant. H. reticulatus can be considered as a source of both natural antioxidants and lauric acid in food industry and pharmacological applications.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 97%

STUDIES ON ANTIOXIDANT PROPERTIES OF THE DIFFERENT SOLVENT EXTRACTS AND FATTY ACID COMPOSITION OFHYOSCYAMUS RETICULATUSL.

Güler

2011

Journal of Food Biochemistry

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“…[161721–23] The substrate and the enzyme solutions were prepared immediately before use. The reaction mixture contained an 80 mM sodium pyrophosphate buffer (pH = 8.5), 0.120 mM xanthine, and 0.1 unit of XO.…”

Section: Methodsmentioning

confidence: 99%

“…[1617] At present, the potential of developing successful natural products for the management of XO-related diseases is still largely unexplored. The screening and optimization of safe and effective XO inhibitors would provide an excellent strategy in combating XO-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants

et al. 2011

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Background:The search for novel xanthine oxidase (XO) inhibitors with a higher therapeutic activity and fewer side effects are desired not only to treat gout but also to combat various other diseases associated with the XO activity. At present, the potential of developing successful natural products for the management of XO-related diseases is still largely unexplored. In the present study, we have screened the methanolic extracts of various Jordanian medicinal plants for their XO inhibitory activities using an optimized protocol.Materials and Methods:The methanolic extracts of 23 medicinal plants, belonging to 12 families, were tested in vitro, at 200 μg/ml concentrations, for their XO inhibitory potential. The dose-dependent inhibition profiles of the most active plants were further evaluated by estimating the IC50 values of their corresponding extracts.Results:Six plants were found most active (% inhibition more than 39%). These plants are Salvia spinosa L. (IC50 = 53.7 μg/ml), Anthemis palestina Boiss. (168.0 μg/ml), Chrysanthemum coronarium L. (199.5 μg/ml), Achillea biebersteinii Afansiev (360.0 μg/ml), Rosmarinus officinalis L. (650.0 μg/ml), and Ginkgo biloba L. (595.8 μg/ml). Moreover, four more plants, namely Lavandula angustifolia Mill. (28.7% inhibition), Helianthemum ledifolium (L.) Mill. (28.4%), Majorana syriaca (L.) Kostel. (25.1%), and Mentha spicata L. (22.5%) showed a XO inhibitory activity in the range of 22–30%.Conclusion:The study showed that many of the tested plant species are potential sources of natural XO inhibitors that can be developed, upon further investigation, into successful herbal drugs for treatment of gout and other XO-related disorders.

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“…For example, anthocyanin extracts of purple sweet potato and Hyoscyamus reticulatus L. (Solanaceae) extracts reversed the elevation of serum uric acid in potassium oxonate-induced hyperuricemia (Mohammad et al, 2010;Hwa et al, 2011). In addition, XO inhibitor-like effects have been shown with an extract…”

Section: Introductionmentioning

confidence: 99%

Hypouricemic effect of the methanol extract fromPrunus mumefruit in mice

et al. 2012

Pharmaceutical Biology

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Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities ofHyoscyamus reticulatus

Cited by 27 publications

References 45 publications

STUDIES ON ANTIOXIDANT PROPERTIES OF THE DIFFERENT SOLVENT EXTRACTS AND FATTY ACID COMPOSITION OFHYOSCYAMUS RETICULATUSL.

STUDIES ON ANTIOXIDANT PROPERTIES OF THE DIFFERENT SOLVENT EXTRACTS AND FATTY ACID COMPOSITION OFHYOSCYAMUS RETICULATUSL.

Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants

Hypouricemic effect of the methanol extract fromPrunus mumefruit in mice

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