Hypouricemic effect of the methanol extract fromPrunus mumefruit in mice

Yi, Long; Li, Jing; Su, Dong-Xue; Dong, Jing-Fang; Li, Cheng-Fu

doi:10.3109/13880209.2012.683115

Cited by 25 publications

(17 citation statements)

References 29 publications

(33 reference statements)

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“…In addition to PA -3, several food items, such as Prunus mume fruits and chrysanthemum flower oil, have been shown to exhibit antihyperuricemic effects 24,25) , probably by inhibiting xanthine oxidase activity 26,27) . Chrysanthemum flower oil alleviates the rise in SUA during purineloading tests, probably by inhibiting the metabolism of nucleic acids, with stronger hypouricemic effects on subjects with SUA levels > 7.1 mg dL -1 than those with SUA levels >6.5 mg dL - 1 28) .…”

Section: Discussionmentioning

confidence: 99%

Yogurt containing Lactobacillus gasseri PA-3 alleviates increases in serum uric acid concentration induced by purine ingestion: a randomized, double-blind, placebo-controlled study

Kurajoh

Moriwaki

Koyama

et al. 2018

GOUT AND NUCLEIC ACID METABOLISM

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Objective : Ingestion of yogurt containing Lactobacillus gasseri PA-3 (PA-3, Accession No : NITE BP-224) (PA-3Y) has been shown to reduce serum uric acid (SUA) levels by interfering with the intestinal absorption of foodderived purines in animal studies. To confirm this mechanism in humans, the ability of PA-3 intake to alleviate purine ingestioninduced increases in SUA levels was analyzed. Research Methods and Procedures : In this randomized, doubleblind, placebocontrolled crossover study, 16 healthy adults were randomized to groups ingesting of 112 g of PA-3Y or yogurt without PA-3 (control yogurt) in addition to standardized meals for 3 days. Purineloading tests, in which subjects ingested 112 g of PA-3Y or control yogurt followed immediately by 498 mg of a mixture of purine nucleotides, were performed on the fourth day of each test period. Blood and urine samples were collected before and after the purineloading tests. Results : The increase in the SUA concentration from the baseline was significantly lower following the ingestion of PA-3Y than of control yogurt alone, especially at 30 (P=0.033) and 60 (P=0.028) minutes. In addition, the area under the curve for the increase in the SUA concentration from the baseline to 150 minutes was also significantly lower (P=0.041) in the PA-3Y than in the control yogurt group. However, urinary and fractional excretions of uric acid were not different between the two groups. Conclusion : The ingestion of PA-3 before purine intake alleviates the increase in SUA levels, probably by reducing purine absorption in the intestine, and not by enhancing urinary excretion of uric acid.

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Section: Discussionmentioning

confidence: 99%

Yogurt containing Lactobacillus gasseri PA-3 alleviates increases in serum uric acid concentration induced by purine ingestion: a randomized, double-blind, placebo-controlled study

Kurajoh

Moriwaki

Koyama

et al. 2018

GOUT AND NUCLEIC ACID METABOLISM

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“…Along with such a trend, new food ingredients with hypouricemic effect are being researched. The methanol extract of a fruit [31], a flavonoid from a traditional herb [32], and onion [33] are demonstrated as hypouricemic substances by animal studies. The hypouricemic effect of fermented barley extract was shown in a human study reported by Hokazono et al [34].…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial

Hosojima

Kaseda

Kondo³

et al. 2016

BMC Nutr

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Background: Rice protein is proved to have hypocholesterolemic and anti-atherosclerotic effects, and a few experimental studies showed its renoprotective effects, using animal diabetic models. However, no clinical studies have investigated its benefits for human health. We aimed to clarify how the intake of rice endosperm protein affects markers correlating to lipid dysfunction in human. Methods: We recruited 18 male volunteers, 26-64 years of age, with risk factors for metabolic syndrome and allocated randomly into two groups. Half of them were administered test food containing rice endosperm protein and other half were administered control food containing sodium caseinate for 4 weeks. The dose of supplemental protein was 10 g/day. After medical examinations, the study foods were switched and the intervention was continued for another 4 weeks. Lipid metabolism markers were evaluated as primary outcome measures. Cross-over analysis was performed for 18 subjects using physical and clinical values measured before and after each intervention period.

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“…Agar-Well diffusion method and paper disc diffusion methods were employed to determine the antimicrobial activities for methanolic extracts 8,9 . , with some modifications.…”

Section: Preparation Of Extractmentioning

confidence: 99%

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2017

IJPSR

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Prunus cornuta (family Rosaceae) commonly known as 'Himalayan Bird Cherry', is a deciduous tree growing to 15 m (49ft 3in) at elevations of 2100-3500 meters. It is hardy to zone (Uttarakhand) 5. It is in flower in May, and the seeds ripen from July to October. The flowers are hermaphrodite and are pollinated by insects and birds. It can grow in semishade (light woodland) or no shade. It prefers moist soil. Plant extract (sample named PC-1) of Prunus cornuta bark was prepared in methanol and the prepared extract was subjected to Phytochemical screening which shows the presence of steroids, terpenoids, alkaloids, tannin, saponin, carbohydrate, protein etc. The methanolic extract ( sample named PC-1) of powdered bark of Prunus cornuta were examined for their antimicrobial activity using agar well diffusion method against different pathogenic bacterial stains like Staphylococcus aureus, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans. Thus minimum inhibitory concentration(MIC) of resulting extract were also checked. The sensitivity of the pathogens was also checked with standard antibiotics erythromycin, Fluconazole, and N-saline. The present study was intended to evaluate the qualitative analysis of P.cornuta methanolic extract and also to examine their antimicrobial activity against different pathogenic bacteria.

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Hypouricemic effect of the methanol extract fromPrunus mumefruit in mice

Cited by 25 publications

References 29 publications

<b>Yogurt containing <i>Lactobacillus</i> <i>gasseri</i> PA-3 alleviates increases in serum uric acid concentration induced by purine ingestion: a randomized, double-blind, placebo-controlled study</b>

<b>Yogurt containing <i>Lactobacillus</i> <i>gasseri</i> PA-3 alleviates increases in serum uric acid concentration induced by purine ingestion: a randomized, double-blind, placebo-controlled study</b>

Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial

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