Antioxidant, Antibacterial, Cytotoxic, and Anti-Inflammatory Potential of the Leaves ofSolanum lycocarpumA. St. Hil. (Solanaceae)

Abstract

Ethanol extract and fractions obtained from leaves of Solanum lycocarpum were examined in order to determine their phenolic composition, antioxidant, antibacterial, anti-inflammatory, and cytotoxic potential. High performance liquid chromatography coupled with DAD analysis indicated that the flavonoids apigenin and kaempferol were the main phenolic compounds present in dichloromethane and ethyl acetate fractions, respectively. The antioxidant activity was significantly more pronounced for dichloromethane, ethyl acetate, and hydroethanol fractions than that of the commercial antioxidant 2,6-di-tert-butyl-4-methylphenol. The hexane and dichloromethane fractions were more active against the tested bacteria. The hydroethanol fraction exhibited significant anti-inflammatory activity at the dose of 75 and 150 mg/kg in the later phase of inflammation. However, the antiedematogenic effect of the higher dose of the ethyl acetate fraction (150 mg/kg) was more pronounced. The ethyl acetate fraction also presented a less cytotoxic effect than the ethanol extract and other fractions. These activities found in S. lycocarpum leaves can be attributed, at least in part, to the presence of phenolic constituents such as flavonoids. This work provided the knowledge of phenolic composition in the extract and fractions and the antioxidant, antibacterial, anti-inflammatory, and cytotoxic activities of leaves of S. lycocarpum.

Potential Use of Vacuum Impregnation and High-Pressure Homogenization to Obtain Functional Products from Lulo Fruit (Solanum quitoense Lam.)

“…The presence of these compounds in food has a positive impact, mainly as free radical scavengers. In addition to their nutritional benefits, they have also been associated with various biological activities such as anti-inflammatory, antitumor, and benefits related to cardiovascular diseases that include hypertension [ 45 , 46 , 47 , 48 ].…”

The physicochemical analysis and health benefits of fresh and branded honey produced in delta state, Nigeria

“…46 The glucose, fructose, and sucrose concentrations in different honey is affected greatly by botanical and geographical origin, climatic factor, processing, and storage techniques. 47 The FHs and BHs honey mean values (Table 2) for glucose and fructose displayed insignificant difference (p > 0.05) within the two types of honey. The fructose and glucose content displayed insignificant difference (p > 0.05) within the two types of honey.…”

Solanum paranenseExtracts and Solanine Present Anti-Inflammatory Activity in an Acute Skin Inflammation Model in Mice

“…Similar results were found by another work from our research group [ 4 ], which demonstrated that the extract of the genus Solanum leaves, species Solanum corymbiflorum , presents skin anti-inflammatory activity in a dermatitis model induced by croton oil. Moreover, Da Costa et al [ 16 ] also showed that the hydroethanol fraction of the genus Solanum leaves, species Solanum lycocarpum , presents antiedematogenic activity in a carrageenan-induced paw edema model.…”