Antioxidant, anti-proliferative and cyclooxygenase-2 inhibitory activities of ethanolic extracts from lemon balm (Melissa officinalis L.) leaves

Lin, Jau-Tien; Chen, Yi‐Chen; Lee, Ying-Chung; Hou, Chien-Wei Rolis; Chen, Fong-Lin; Yang, Daizhi

doi:10.1016/j.lwt.2012.04.009

Cited by 57 publications

(43 citation statements)

References 29 publications

(34 reference statements)

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“…The high content of total phenols and flavonoids reported here for the ethanolic leaves extract of MO is in line with previous studies on this plant [13; 48]. Lin et al [13] reported that for MO cultivated in Taiwan, the ethanolic extract of its leaves contained phenolic acids including gallic, caffeic, p-coumaric, protocatechuic, chlorogenic, and rosmarinic acid, as well as flavonoids including (+) p-catechin, p-epicatechin, hesperetin, eriodictiol, hesperidin, naringin, lutenolin, and naringenin where rosmarinic acid was the major ingredient. In the present investigation, the detected phenolic compounds in our MO samples were gallic, caffeic, syringic, ferulic acid, and rosmarinic acid.…”

Section: Discussionsupporting

confidence: 93%

“…In the present investigation, the detected phenolic compounds in our MO samples were gallic, caffeic, syringic, ferulic acid, and rosmarinic acid. Rosmarinic acid was also the main compound of the plant extract which is consistent with earlier studies [13; 15; 49]. The average content of phenolic acids analyzed here in the present lemon balm samples is quite comparable with contents reported elsewhere [15].…”

Section: Discussionsupporting

confidence: 93%

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Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells

et al. 2016

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Cardiotoxicity is a limiting factor of doxorubicin (DOX)-based anticancer therapy. Due to its beneficial effects, we investigated whether standardized extract of Melissa officinalis (MO) can attenuate doxorubicin-induced cardiotoxicity and can potentiate the efficacy of DOX against human breast cancer cells. MO was administered orally to male albino rats once daily for 10 consecutive days at doses of 250, 500 and 750 mg/kg b.wt. DOX (15 mg/kg b.wt. i.p.) was administered on the 8th day. MO protected against DOX-induced leakage of cardiac enzymes and histopathological changes. MO ameliorated DOX-induced oxidative stress as evidenced by decreasing lipid peroxidation, protein oxidation and total oxidant capacity depletion and by increasing antioxidant capacity. Additionally, MO pretreatment inhibited inflammatory responses to DOX by decreasing the expressions of nuclear factor kappa-B, tumor necrosis factor-alpha and cyclooxygenase-2 and the activity of myeloperoxidase. MO ameliorated DOX-induced apoptotic tissue damage in heart of rats. In vitro study showed that MO augmented the anticancer efficacy of DOX in human breast cancer cells (MCF-7) and potentiated oxidative damage and apoptosis. Thus, combination of DOX and MO may prove future cancer treatment protocols safer and more efficient.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells

et al. 2016

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“…In recent years, there has been an increasing interest in the relationship between bioactive compounds, such as flavonoids, and human health benefits, mostly due to positive effects on the prevention of cancer, cardiovascular and autoimmune diseases. As a result of these benefits, there is an interest in replacing synthetic food antioxidant substances with natural ones, which has fostered research on vegetable sources and the screening of waste materials aimed at identifying new and/or better antioxidant sources …”

Section: Introductionmentioning

confidence: 99%

“…As a result of these benefits, there is an interest in replacing synthetic food antioxidant substances with natural ones, which has fostered research on vegetable sources and the screening of waste materials aimed at identifying new and/or better antioxidant sources. [1][2][3][4] Phenolic compounds are bioactive substances widely distributed in plants. However, the amount of these compounds as well as their structure (the number of phenolic hydroxyl groups and their position) vary according to each vegetal matrix, leading to variations in their biological activity.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous extraction and biotransformation process to obtain high bioactivity phenolic compounds from brazilian citrus residues

Madeira

Macêdo

2015

Biotechnol Progress

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Recent studies have pointed to a reduction in the incidence of some cancers, diabetes, and neuro-degenerative diseases as a result of human health benefits from flavanones. Currently, flavanones are obtained by chemical synthesis or extraction from plants, and these processes are only produced in the glycosylated form. An interesting environmentally friendly alternative that deserves attention regarding phenolic compound production is the simultaneous extraction and biotransformation of these molecules. Orange juice consumption has become a worldwide dietary habit and Brazil is the largest producer of orange juice in the world. Approximately half of the citrus fruit is discarded after the juice is processed, thus generating large amounts of residues (peel and pectinolytic material). Hence, finding an environmentally clean technique to extract natural products and bioactive compounds from different plant materials has presented a challenging task over the last decades. The aim of this study was to obtain phenolics from Brazilian citrus residues with high bioactivity, using simultaneous extraction (cellulase and pectinase) and biotransformation (tannase) by enzymatic process. The highest hesperetin, naringenin and ellagic acid production in the experiment were 120, 80, and 11,250 µg g(-1), respectively, at 5.0 U mL(-1) of cellulase and 7.0 U mL(-1) of tannase at 40°C and 200 rpm. Also, the development of this process generated an increase of 77% in the total antioxidant capacity. These results suggest that the bioprocess obtained innovative results where the simultaneous enzymatic and biotransformatic extracted flavanones from agro-industrial residues was achieved without the use of organic solvents. The methodology can therefore be considered a green technology.

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“…Medicinal plants contain a wide range of substantive bioactive components like polyphenols, tannins, alkaloids, terpenes, anthocyanidins and vitamins which exert astounding health benefits by acting as reducing agents and detoxifying free radicals [ 5,6,7 ]. It is now well established that making medicinal plants a regular part of everyday diet subverts the harmful effects of free radicals and immensely decreases the chances of getting diseases like cardiovascular, neurodegenerative, cancer, arteriosclerosis and parkinson [ 8,9 ]. Acacia catechu Willd.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity

Kumar

Arora

Mahajan

et al. 2018

Braz. arch. biol. technol.

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Antioxidant, anti-proliferative and cyclooxygenase-2 inhibitory activities of ethanolic extracts from lemon balm (Melissa officinalis L.) leaves

Cited by 57 publications

References 29 publications

Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells

Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells

Simultaneous extraction and biotransformation process to obtain high bioactivity phenolic compounds from brazilian citrus residues

Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity

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