Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity

Kumar, Rajeev; Arora, Rohit; Mahajan, Jyoti; Mahey, Sonia; Arora, Saroj

doi:10.1590/1678-4324-2017160728

Cited by 8 publications

(8 citation statements)

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“…An enzymatic unity is defined as being equal with amount of enzyme required to cause 50% inhibition of the NBT reduction. The superoxide radicals are comparatively less toxic but are highly reactive and leads to a series of chain reactions thus generating very toxic radicals via Haber Weiss reaction [17]. The specialty literature signalize the fact that the metals can be essential and non-essential for the plants' growth, with different answers in function of the concentration for both classes, some of them having a crucial role for the vegetable organisms' metabolism, while others, even at reduced concentrations, produce imbalances at the level of biochemical and physiological processes with repercussions on the plants' growth and productivity [18][19][20].…”

Section: Resultsmentioning

confidence: 99%

Heavy Metals and 2,4-Dinitrophenol Impact on Some Physiological and Biochemical Parameters in Capsicum Species

Todirascu-Ciornea

Dumitru

2019

Braz. arch. biol. technol.

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The accumulation of heavy metals and of pesticides in the soil have a negative impact on Capsicum chinense var. Aji Mochero and Capsicum baccatum var. pendulum Bishop's Crown species, the present work highlighting the exerted influence on the superoxid-dismutase activity, catalase and peroxidaseas enzymes implied in the removal of H 2 O 2 , of O 2radical and of ion HOthat have devastating effects on the vegetable cell, on the Krebs cycle's dehydrogenasesas main way to produce energy, respectively of the chlorophyll a, b and carotenesas photoassimilatory pigments, but also as biologic antioxidants.

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Section: Resultsmentioning

confidence: 99%

Heavy Metals and 2,4-Dinitrophenol Impact on Some Physiological and Biochemical Parameters in Capsicum Species

Todirascu-Ciornea

Dumitru

2019

Braz. arch. biol. technol.

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“…rough ultrahigh performance liquid chromatography (UHPLC) analysis, A. catechu extract was found to contain ellagic acid (19), rutin (26), quercetin (16), gallic acid (27), catechin (5), chlorogenic acid (28), umbelliferone (29), kaempferol (13), epicatechin (6), coumaric acid (30), and caffeic acid (31) (Figure 2) [36]. Additionally, camphor (32), phytol (33), hexadecane (34), and vitamin E acetate (35) (Figure 2) were identified from leaf extract of the plant [21].…”

Section: Chemical Composition and Pharmacological Applicationsmentioning

confidence: 99%

“…[58]. Moreover, methanol extract of A. catechu showed DPPH radical and ABTS (2,2azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)) radical scavenging activities (IC 50 : 101.74 and 140.41 μg/mL), superoxide radical and peroxyl radical scavenging activities (IC 50 : 175.90 and 152.76 μg/mL), and cupric ion and ferric ion reducing power (IC 50 : 184.30 and 232.13 μg/mL) [36]. Similarly, the methanol, ethanol, butanol, and aqueous fractions of A. catechu showed an antioxidant property with IC 50 ranges of 92.48-529.30 μg/mL on DPPH radical, ABTS radical, superoxide radical scavenging assays, and cupric ion and ferric ion reducing assays mainly due to the presence of quercetin (16), kaempferol (13), and chlorogenic acid (28) (Figure 2) [13].…”

Section: Antidiabetic Activities a Catechu Extracts Show Anmentioning

confidence: 99%

A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.

Adhikari

Aryal

Bhattarai

2021

Journal of Chemistry

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With the emergence of epidemics, pandemics, and infectious diseases, several research activities have been carried out on natural products to tackle them. As there are structural diversities in natural products, researchers are focused on exploring them for treatment and/or management of various infections and/or diseases. Acacia catechu (L.f.) Willd. belonging to the order Fabales and family Fabaceae shows a wide range of pharmacological functions in the management of diseases in humankind. This review was carried out to gather and provide information about the chemical constituents and pharmacological activities of A. catechu through the literature survey of scientific articles. On preliminary assessments, A. catechu is demonstrated as a significant wellspring of bioactive compounds with a wide range of biological and pharmaceutical applications such as antidiabetic, antioxidant, antimicrobial, anticancer, antidiarrheal, anti-inflammatory, antiviral, hepatoprotective, immunomodulatory, and so on. Although the metabolites from the plant are reported with diverse pharmacological applications, there is little information in regards to toxicity and clinical trials on bioactive compounds of this plant. Further research on diverse bioactive compounds from the plant is required to develop them as a successful potent drug.

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“…Additionally, A. catechu has several medicinal properties such as immune-modulatory, sore throat, anti-inflammatory, anti-viral, anti-microbial activities and wound healing [8,9]. A Leaf methanol extract of A. catechu provided antioxidant, DNA protective and antiproliferative properties [10].…”

Section: Introductionmentioning

confidence: 99%

Formulation Strategy, Stability Issues, Safety and Efficacy Evaluations of Acacia Catechu Whitening Cream

2019

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Objective: To investigate among formulation strategy, stability issues, safety and efficacy (tyrosinase inhibitory activity and sun protection) of a novel whitening cream containing Acacia catechu heartwood extract. Methods:The tyrosinase inhibitory activity of the A. catechu extract was investigated using L-DOPA as a substrate. A combination of silicone and three photo-protective filters; natural UV filter (A. catechu extract), chemical and physical filters, was formulated and evaluated. The Sun Protection Factor (SPF), stability, skin allergy or irritation, and the satisfaction of the developed whitening creams, were investigated.Results: The A. catechu extract showed the strong tyrosinase inhibitory activity with the percentage of inhibition of 61.58% at the concentration of 120 µg/ml compared to a positive control of kojic acid (98.73 % inhibition) at the same concentration of 120 µg/ml. impressively, the highest SPF of A. catechu whitening cream with physical and chemical UV filters was 30. While, the highest SPF of the A. catechu whitening cream without those filters, was 24. No changes in color, liquefaction and phase separation were observed for the developed whitening cream when stored in the refrigerator. Among the twenty volunteers, eighteen volunteers had no skin irritation, while one of them had redness (Transient) and then another one had erythema or very slight irritation to the developed whitening creams. Besides, there was no statistically significant difference for the satisfaction between A. catechu whitening creams and commercial whitening creams (p>0.05). Conclusion:Obviously, A. catechu whitening creams had very high efficacy, stability, and safety for being a commercial product in a near future. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

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Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity

Abstract: ABSTRACT

Cited by 8 publications

References 36 publications

Heavy Metals and 2,4-Dinitrophenol Impact on Some Physiological and Biochemical Parameters in Capsicum Species

Heavy Metals and 2,4-Dinitrophenol Impact on Some Physiological and Biochemical Parameters in Capsicum Species

A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.

Formulation Strategy, Stability Issues, Safety and Efficacy Evaluations of Acacia Catechu Whitening Cream

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