Antioxidant and protective effects of Royal jelly on histopathological changes in testis of diabetic rats

Ghanbari, Elham; Nejati, Vahid; Khazaei, Mozafar

doi:10.29252/ijrm.14.8.519

Cited by 76 publications

(59 citation statements)

References 33 publications

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“…This antioxidant property of D. arborea extracts could be associated with the enhancement of the fertility parameters observed in the current study. This result is in accordance with those of other authors using different plant materials (Bal et al, ; Ghanbari, Nejati, & Khazaei, ). The fertilising and antioxidant properties could be correlated with its androgenic effects.…”

Section: Discussionsupporting

confidence: 93%

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

et al. 2019

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Reproductive dysfunction is one of the most prevalent diabetes complications. Draceana arborea is known to enhance sexual function in diabetic rats, but the underlying mechanisms have not been thoroughly elucidated. This study examined the effects of D. arborea on some reproductive complications of diabetes in rats. Aqueous and ethanol (500 and 100 mg/kg respectively) extracts of D. arborea, Sildenafil citrate (1.44 mg/kg), trimethylamine‐N‐oxide (TMAO, 20 mg/kg) and distilled water (10 ml/kg) were orally administered for 28 days to streptozotocin‐induced diabetic rats. Glycaemia, body and reproductive organ masses, fertility parameters, total proteins, antioxidant enzymes activities, serum and testicular testosterone and the histology of the testes and epididymis were determined. Results revealed significant decreases in body and absolute and relative masses of testes, epididymis, seminal vesicles, prostate and vas deferens, fertility parameters, epididymal and testicular total proteins, serum and testicular testosterone levels as well as antioxidant enzymes activities. Interestingly, while having minor anti‐hyperglycaemic effects, these abnormalities associated with testicular and epididymal alterations were alleviated by D. arborea especially the aqueous extract (500 mg/kg). These outcomes provided evidence of the androgenic properties of D. arborea in diabetic rats, which could be useful for a better management of sexual dysfunctions in diabetic patients.

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Section: Discussionsupporting

confidence: 93%

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

et al. 2019

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“…Overall, we found that RJ co‐treated animals exhibited enhanced pre‐implantation embryo development as well as improved sperm characteristics vs. HS‐only ones. Confirming our findings, earlier reports have shown that RJ has positive effects on histological alterations amelioration and antioxidant defence system reinforcement in male diabetic rat reproductive system (Ghanbari, Nejati, & Khazaei, ). It has been also found that RJ improves sperm kinematic parameters, DNA fragmentation and lipid peroxidation in streptozotocin‐induced diabetic animal models (Ghanbari et al, ) and protects against stanozolol‐induced sperm abnormality and embryo toxicity (Jalali, Najafi, Hosseinchi, et al, ).…”

Section: Discussionsupporting

confidence: 93%

Royal jelly protects male rats from heat stress‐induced reproductive failure

et al. 2018

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Royal jelly (RJ) as an antioxidant has been shown to have attenuated oxidative stress damages in reproductive organs. The objective was carried out the effects of RJ on sperm characteristics, sperm malondialdehyde (MDA) concentration and in vitro fertilisation (IVF) outcome in heat stress (HS) exposed male rats. Forty-eight male rats were randomly divided into eight groups; group 1 received normal saline, group 2 received RJ (100 mg kg −1 day −1 ; PO), groups 3, 4 and 5 were heat-stressed (43, 39 and 37°C for 20 min per day respectively) and groups 6, 7 and 8 were heat-stressed along with RJ (43, 39 and 37°C for 20 min per day, respectively, plus RJ at a dose of 100 mg kg −1 day −1 ; PO). The HS was induced through immersion of experimental rat scrotums in a water bath. After 48 days, the HS induced remarkable diminish in sperm motility, viability and fertilising potential along with reduced blastulation rate and enhanced sperm chromatin abnormality, MDA levels and DNA damage.Nevertheless, RJ co-administration improved sperm characteristics and early embryo development as well as sperm lipid peroxidation level. Our data suggest that RJ can effectively ameliorate the experimental HS-induced infertility in rats through MDA concentration restoration and sperm characteristics and pre-implantation embryo development improvement. K E Y W O R D Searly embryo development, heat stress, malondialdehyde, rat, royal jelly, sperm

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“…It includes major proteins with high contents of essential amino acids and peptides having high antioxidant and scavenging properties against free radicals [40] . Also, the antioxidant activity and biological benefits are due to polyphenols and phenols as flavonoids in major protein structures [41,42] .…”

Section: Discussionmentioning

confidence: 99%

The effect of ethanol on rat tongue and the possible protective role of royal jelly: Light and scanning electron microscopic study

Altayeb

Salem

2017

Egyptian Journal of Histology

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Background: Ethanol is the most commonly used and abused xenobiotic in the world. Royal jelly (RJ) has been considered as an antioxidant that protects against different agents. Aim of the work: This study aimed to investigate the effect of ethanol on the rat tongue and the possible protective role of royal jelly. Material and methods: Twenty five adult male rats were used in this study and were divided into 4 groups. Group I: 10 rats were divided equally into negative and positive controls. Group II: 5 rats received RJ at a dose of 100 mg/kg body weight by gastric tube daily for 30 days. Group III: 5 rats received ethanol at a dose of 10 ml/kg body weight from 30% v/v ethanol solution in distilled water by a gastric tube daily for 30 days. Group IV: 5 rats received both RJ and ethanol as the same previous doses by gastric tube for 30 days. Tongue sections were histologically prepared and examined. Results:The results revealed that group II was nearly as group I. Group III revealed by LM dorsal surface of the tongue was covered by irregularly arranged, short and long lingual papillae. Some papillae were thin, with blunted tips and others were completely absent. The epithelial lining of the ventral surface also showed an apparent reduction in thickness. The keratin layer of the ventral surfaces of the tongue appeared in some regions discontinuous and detached. Some skeletal muscle fibers revealed separations and vacuolations. Scanning electron microscope (SEM) examination revealed a noticeable atrophy of lingual papillae from being short to being absent in focal areas. They were irregularly arranged in different directions. Group IV revealed amelioration of these changes. Conclusion: Ethanol has damaging effects on the lingual papillae and muscles and royal jelly has a protective role for these effects.

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Antioxidant and protective effects of Royal jelly on histopathological changes in testis of diabetic rats

Cited by 76 publications

References 33 publications

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

Royal jelly protects male rats from heat stress‐induced reproductive failure

The effect of ethanol on rat tongue and the possible protective role of royal jelly: Light and scanning electron microscopic study

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