Antioxidant and protective effect of Curculigo orchioides on liver, pancreas and kidney tissue in alloxan induced diabetic experimental rats

Elumalai, A.; Chandiran, Irisappan Sarath; Kanimozhi, Veerasamy; Kadalmani, Balamuthu

doi:10.1016/j.dit.2013.08.002

Cited by 9 publications

(2 citation statements)

References 29 publications

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“…C. orchioides has been widely used in Asian indigenous medicine and has suggested hepatoprotective, antioxidant, anti-cancer [ 12 , 13 ], neuroprotective, and anti-inflammatory affects [ 12 , 14 ]. C. orchioides has also been used to enhance memory [ 15 ], improve the immune system and rejuvenation [ 5 , 16 ], and to treat a variety of diseases including diabetes [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model

Bui-Le

Quảng

Hoang-Viet

et al. 2023

CIMB

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Curculigo orchioides Gaertn. is a precious herb used in traditional medicine systems in Asian countries for various health benefits. This study investigated the potential protective effects of C. orchioides extract on reproductive health under heat stress conditions in male mice. Forty-eight mice were divided into eight groups, control condition (C group), C. orchioides extract at the dosages of 100, 200, and 400 mg/kg/day (C100, C200, C400 group), 40 °C heat exposure (H group), and combined 40 °C heat exposure and C. orchioides extract at the dosages of 100, 200, and 400 mg/kg/day (HC100, HC200, HC400 group). The result shows that the mice that received only C. orchioides extract without heat stress do not have a significant change in histological structure and testosterone level. The histological analysis of testicular tissue showed that heat stress conditions reduced reproductive function and inhibited the spermatogenesis of male mice. The C. orchioides rhizome extract treatment attenuated the heat stress-induced spermatogenesis complications in the murine model. Mice in the heat-stress group treated with C. orchioides extract had increased spermatogenic cells and spermatozoa compared with mice exposed to heat without C. orchioides treatment. Moreover, the aqueous extract of C. orchioides rhizome enhanced the serum total testosterone levels in heat-exposed mice. In conclusion, the study findings validate that C. orchioides is effective against heat stress-induced spermatogenesis complications in the murine model.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model

Bui-Le

Quảng

Hoang-Viet

et al. 2023

CIMB

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“…For plants growing in their native habitat, antioxidants and free radical scavenging capacities of Amaryllidaceae were studied and high values indicating possible pharmacological uses were occasionally reported. Although Curculigo orchioides, an amaryllid, was not involved in this study, it is worth mentioning that its methanolic extracts have significant antioxidant and protective effects in diabetic rats [5]. Curculioside, a phenolic compound of this plant, has a significant antioxidative capacity and as such it was suggested to be potentially used in the treatment of osteoporosis [6].…”

Section: Digital Signaturementioning

confidence: 99%

Production and antioxidant capacity of tissue cultures from four Amaryllidaceae species

et al. 2017

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The aim of this study was (i) to produce tissue cultures capable of efficient plant regeneration from European naturally occurring protected and/or pharmacologically important Amaryllidaceae species and (ii) to test them for antioxidant activities in order to select tissue cultures that scavenge efficiently oxygen radicals. Bulb explants were collected from Galanthus woronowii, two Leucojum species, and Sternbergia lutea. Leucojum species were Hungarian isolates. Mostly α-naphthalene acetic acid (NAA) and benzyladenine (BA) were used as growth regulator combinations for the induction and maintenance of tissue cultures and further antioxidant activity studies. Galanthus woronowii and L. vernum cultures produced shoots or whole plants via micropropagation (callus stage was observed only sporadically and callus tissue did not contribute to regeneration), whereas L. aestivum and S. lutea produced efficiently whole plants or multiple shoots via embryogenic calli. Total phenolic content, % inhibition of ABTS radical (ABTS*) cation, and peroxidase activities on native polyacrylamide gels were studied and showed differences between cultures. No relationship could be detected between polyphenol content / radical scavenging capacities and H 2 O 2 reducing enzyme activities. For G. woronowii, S. lutea, and a culture line of L. vernum, polyphenol content and ABTS* cation scavenging activities were high and for G. woronowii, comparable to organs of the native plants used as explant sources. Bulbs of native plants showed low radical scavenging activities in general. For L. vernum and L. aestivum tissue cultures grown in the presence of NAA as the sole growth regulator, ABTS* cation scavenging showed low values. Enzymatic antioxidant (pyrogallol peroxidase) activities were low for all cultures and organs of native plants. This study shows the species conservation value of these cultures and highlights the high antioxidant capacity of G. woronowii and S. lutea, attributed to the presence of non-enzymatic scavengers.

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Biotechnological Approaches to Medicinal Plants of Aravalli Hills: Conservation and Scientific Validation of Biological Activities

Goyal

Arora

Ramawat

2014

Sustainable Development and Biodiversity

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Antioxidant and protective effect of Curculigo orchioides on liver, pancreas and kidney tissue in alloxan induced diabetic experimental rats

Cited by 9 publications

References 29 publications

Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model

Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model

Production and antioxidant capacity of tissue cultures from four Amaryllidaceae species

Biotechnological Approaches to Medicinal Plants of Aravalli Hills: Conservation and Scientific Validation of Biological Activities

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