Antioxidant and nephro-protective effect of Juglans regia vegetable oil against lead-induced nephrotoxicity in rats and its characterization by GC-MS

Soussi, Ahlem; Akrouti, Amel; Feki, Abdelfattah El

doi:10.17179/excli2018-1235

Cited by 7 publications

(7 citation statements)

References 55 publications

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“…The nephroprotective activity of trevo against lead toxicity can be linked to the presence of various antioxidant phytochemicals in that product. Plants rich antioxidant have been effective in countering lead toxicity, since they serve as metal chelators, radical scavengers and terminator of various oxidative processes [1,4,13,17,39,42,46].…”

Section: Discussionmentioning

confidence: 99%

“…Lead has been reported to damage the nervous, reproductive, hematopoietic, respiratory and excretory systems, such as kidneys and liver [7][8][9][10]. Kidneys are particularly prone to the toxic effect of lead, since they play an important role in its excretion [4,11,12]. Biologically, lead has no health benefit to humans; however, its bioaccumulation in the body leads to various injuries as stated earlier [13].…”

Section: Introductionmentioning

confidence: 92%

“…Industrial growth in automobiles, electrical, agricultural, and construction industries contribute to the observed increased concentration of lead in the environment [1]. The toxic effects of lead have been reported in the organs of experimental animals [4][5][6]. Lead has been reported to damage the nervous, reproductive, hematopoietic, respiratory and excretory systems, such as kidneys and liver [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effect of Trevo Dietary Supplement Against Lead Acetate Nephrotoxicity

Ilesanmi

Agoro

2022

IJT

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Background: Trevo is a nutritional supplement with numerous bioactive natural products, with detoxifying and antioxidant properties. The purpose of this study was to investigate the ability of Trévo to protect against oxidative stress induced by lead in the kidneys of male Wistar rats. Methods: Thirty-five healthy male Wistar rats were divided into five groups of seven rats each, using a randomized design. I=control; II=15 mg/kg of lead acetate (PbA); III=2 ml/kg of trevo+PbA; IV=5 ml/kg of trevo+PbA; V=5 ml/kg of trevo. Animals were treated with trevo for five days before co-administration with lead intraperitoneally for 10 consecutive days. Animals were sacrificed 24hr after the last administration, blood samples were collected via cardiac puncture, and processed for assessment of urea, creatinine, and uric acid (UA), while the kidney samples were excised and processed for the following biochemical assays: Malondialdehyde (MDA), Glutathione-S-Transferase (GST), Catalase (CAT), Superoxide Dismutase (SOD), and Reduced Glutathione (GSH). Results: Injection of PbA caused a significant increase in the serum levels of urea, creatinine, and uric acid, and a significant increase (P<0.001) in the MDA concentration, and decreases in GSH concentration, CAT, SOD, and GST activities (P<0.05) as compared to the controls. Pretreatment with trevo prevented the oxidative stress induced by lead acetate in the kidney tissue samples and improve the renal function. The protective effect was evident at 5 ml/kg of trevo. Conclusion: The results showed that trevo was nephroprotective against lead toxicity and the activity might be linked to the presence of numerous antioxidant phytochemicals present in trevo.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effect of Trevo Dietary Supplement Against Lead Acetate Nephrotoxicity

Ilesanmi

Agoro

2022

IJT

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“…Walnut oil effectively reduced serum and hepatic malondialdehyde (MDA), hepatic NF-κB, and p22phox levels; modulated carbohydrate metabolism; and improved antioxidant capacity (Gencoglu et al, 2020). In another study, walnut oil was found to inhibit oxidative damage in lead-mediated hepatic or nephrotoxic injury, thus demonstrating its potent antioxidant efficacy (Soussi, Gargouri, Akrouti, & El Feki, 2018;.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Research progress on Walnut oil: Bioactive compounds, health benefits, extraction methods, and medicinal uses

Song

Cong²,

et al. 2022

Journal of Food Biochemistry

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Walnut oil is extracted from walnut kernels (Juglans regia Linne) or iron walnut kernels (Juhlans sigillata Dode). The percentage of oil in walnuts is 52%–70%. The main constituents in oil are fatty acids, phenols, sterols, squalene, melatonin, vitamins, and minerals. Many extraction methods such as supercritical carbon dioxide extraction, maceration, modified “bligh and dyer extraction,” aqueous enzymatic extraction, ultrasonic extraction, soxhlet extraction, and cold‐press extraction methods are reported in the literature. Walnut oil showed anti‐inflammatory, antitumor, antioxidant, immunomodulatory, neuroprotective, cardioprotective, antidiabetic, and antihyperlipidemic activities. The reported data in the literature suggest that walnut oil has many health benefits. This review summarizes the extraction methods, bioactive constituents, health benefits, and pharmacological actions of walnut oil. Practical applications Walnut oil is a natural vegetable oil of significant importance due to their nutritional, and intelligence‐boosting benefits. Several factors, including the processing parameters and the phytochemical profile, affect walnut oil products’ flavor and color. In addition, storage environment of walnut oil can also affect walnut oil quality. Apart from the predominant ingredient fatty acids, the chemical composition of walnut oil comprises phenols, sterols, squalene, melatonin, vitamins, and minerals. These bioactive compounds are of potential value owing to their health‐promoting benefits, including antioxidant, antitumor, and cholesterol‐lowering effects. Many chemical constituents were isolated from walnut oil; however, all the compounds are not explored for their possible medicinal value. Thus, clinical studies, exploration of the therapeutic potential and the molecular mechanisms of all the compounds, and development of convenient dosage forms either for therapeutic or functional food purposes are warranted.

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“…Moreover, long-term exposure to lead causes inflammatory infiltration, alterations in tissues of testicles, reduction in spermatocytes, necrosis of hepatocytes, degeneration of renal tubules, hypertrophy in the renal epithelium and induces endoplasmic reticulum stress due to calcium imbalance in the liver and kidney. 6,7 Kidneys are prone to the oxidative reaction of lead as lead intoxication sometimes causes dysfunctioning of proximal tubule or irreversible nephropathy depending on exposure regimens, thus adversely affecting the health of kidney function along with cadmium and mercury 8–10 and can be excreted through urine and feces. 11 It affects central nervous system causing several neurological disturbances affects the blood–brain barrier and causes edema and loss of neurons.…”

Section: Introductionmentioning

confidence: 99%

Protection of lead-induced cytotoxicity using paramagnetic nickel–insulin quantum clusters

et al. 2021

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Antioxidant and nephro-protective effect of Juglans regia vegetable oil against lead-induced nephrotoxicity in rats and its characterization by GC-MS

Cited by 7 publications

References 55 publications

Ameliorative Effect of Trevo Dietary Supplement Against Lead Acetate Nephrotoxicity

Ameliorative Effect of Trevo Dietary Supplement Against Lead Acetate Nephrotoxicity

Research progress on Walnut oil: Bioactive compounds, health benefits, extraction methods, and medicinal uses

Protection of lead-induced cytotoxicity using paramagnetic nickel–insulin quantum clusters

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