Antioxidant and lipid lowering effects of dried fruits oil extract of Pterodon emarginatusin Caenorhabditis elegans

Forno, Ana Helena Dal; Câmara, Daniela De Freitas; Parise, Bruna; Rodrigues, Cristiane Freitas; Soares, Jefferson J.; Wagner, Róger; Ribeiro, Stéphanie Reis; Folmer, Vanderlei; Puntel, Robson Luiz; Haas, Sandra Elisa; Farias, Fabiane Moreira; Denardin, Elton Luís Gasparotto; Denardin, Cristiane Casagrande; Ávila, Daiana Silva

doi:10.1016/j.arabjc.2016.04.001

Cited by 12 publications

(7 citation statements)

References 42 publications

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“…The results obtained for the toxicity for DW_EO showed low toxicity against C. elegans, similar to those recommended in C. elegans studies (1 mg/ml) (Dal Forno et al, 2019). Satyal and Dosoky, reported marginally EO toxicity obtained from Amomum subulatum (Satyal et al, 2012).…”

Section: Compound Cyp2c9supporting

confidence: 83%

The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

Bruna

Fernández²,

Urrejola³

et al. 2022

Front. Nat. Prod.

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The Mapuche and their ancestors have used D. winteri in traditional medicine. In the present study, the essential oil extract of D. winteri leaves (DW_EO) were characterized chemically and biologically to evaluate its pharmacological activity. In vitro antioxidant activity was assayed, and antitumor activity was evaluated in non-tumor and tumor-cell culture lines. Caenorhabditis elegans was used as a model to evaluate toxicity, and the chemical composition of the essential oil was analyzed by gas chromatography-mass spectrometry. The chemical oil composition was characterized principally of five major terpenes: 4 sesquiterpenes γ-Eudesmol (39.7%), β-Caryophyllene (33.7%), Elemol (25.9%), α-Eudesmol (0.3%) and 1 diterpene Kaunene (0.4%). By quantum calculations, it was determined that all oils have the ability to capture and yield electrons, which is consistent with the moderate antioxidant activity of DW_EO detected in vitro. Furthermore, by molecular docking is estimated that these oils can bind to proteins involved in the production of oxygen radicals. Of these proteins, CYP2C9 could bind energetically, reaching binding energy between −6.8 and −9.2 kCal/mol for the 5 terpenes studied, highlighting among these β-Caryophyllen and γ-Eudesmol. DW_EO has effect against H. pylori (MIC 32 μg/ml), S. aureus (MIC 8 μg/ml), E. coli (MIC 32 μg/ml) and C. albicans (MIC 64 μg/ml), β-Caryophyllen and γ -Eudesmol (MIC 64 μg/ml) and could selectively inhibit the proliferation of epithelial tumor cell lines but showed low against C. elegans (0.39–1.56 μg mL−1). Therefore, DW_EO may be used as a source of bioactive compounds in novel pharmacological treatments for medical application, agronomics, sanitation, and food.

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Section: Compound Cyp2c9supporting

confidence: 83%

The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

Bruna

Fernández²,

Urrejola³

et al. 2022

Front. Nat. Prod.

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“…The CA_EO showed some level of toxicity at the highest concentrations (50-3.125 mg/mL) higher than those recommended for studies in C. elegans (1 mg/mL), Forno [39], demonstrating that this oil presented low or no toxicity. Similar to what was reported Larrazabal [19], using oils from Rica rica and Copa copa showed low toxicity in C. elegans.…”

Section: Discussionmentioning

confidence: 80%

The Chemical Compositions of Essential Oils Derived from Cryptocarya alba and Laurelia sempervirens Possess Antioxidant, Antibacterial and Antitumoral Activity Potential

et al. 2020

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Cryptocarya alba (Peumo; CA) and Laurelia sempervirens (Laurel; LS) are herbs native to the Chilean highlands and have historically been used for medicinal purposes by the Huilliches people. In this work, the essential oils were extracted using hydrodistillation in Clevenger apparatus and analyzed by GC-MS to determine their composition. The antioxidant capacity (AC) was evaluated in vitro. The cytotoxicity was determined using cell line cultures both non tumoral and tumoral. The toxicity was determined using the nematode Caenorhabditis elegans. The antimicrobial activity was evaluated against 52 bacteria using the agar disc diffusion method and the minimum inhibitory concentrations (MICs) were determined. The principal compounds found in C. alba essential oil (CA_EO) were α-terpineol (24.96%) and eucalyptol (21.63%) and were isazafrol (91.9%) in L. sempervirens essential oil (LS_EO). Both EOs showed antioxidant capacity in vitro. Both EO showed antibacterial activity against bacteria using. LS_EO showed more inhibitory effect on these cell lines respect to CA_EO. Both EOs showed toxicity against the nematode C.elegans at 3.12–50 mg/mL. The essential oils of CA and LS have an important bioactive potential in their antioxidant, antibacterial and cytotoxicity activity. Both essential oils could possibly be used in the field of natural medicine, natural food preservation, cosmetics, sanitation and plaguicides among others.

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“…[51,52] The antioxidant activity of flavonoids is due to the presence of hydroxyl groups which interact with ROS. [9,53] Inhibition of oxidative stress by these molecules has also been observed in vivo. [49] Literature reports the inhibition of lipid peroxidation caused by ROS generated after intense exercise in rats with the antioxidant activity of phenolic compounds and terpenes present in P. emarginatus extract.…”

Section: Figure 7 Intracellular Formation Of Reactive Oxygen Species mentioning

confidence: 98%

Protective effect of sucupira oil nanoemulsion against oxidative stress in UVA-irradiated HaCaT cells

Pacheco

Silva

Nascimento

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Bioactive molecules derived from natural products combine the ability to absorb UV light and act as antioxidants. We developed an oil‐based sucupira (native species of the Brazilian cerrado) nanoemulsion (NE) using a high‐energy emulsification method and assessed its effectiveness in vitro. Methods An easily scalable high‐pressure homogenization method was used to prepare the formulation. NE droplets mean diameter, pH, stability, conductivity and morphology were analysed. Formulation bioactivity was assessed using HaCaT cells. Key findings The formulation presented suitable pH and size for topic administration and was stable for over 90 days upon storage at 4, 25 and 45°C. The NE showed protective effect against oxidative stress and reduced levels of UVA‐induced pro‐inflammatory cytokines IL‐6 and IL‐8. Conclusions A novel, stable and easily prepared formulation was obtained for encapsulation of sucupira oil. The protective effect of the formulation by cytokine inhibition in the early stage of the inflammatory process was shown in vitro. Combined with the antioxidant effect by inhibition of reactive oxygen species, the use of sucupira oil NE for prevention and treatment of UVA‐induced stress could contribute to decrease the effects of UV radiation on skin ageing.

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Antioxidant and lipid lowering effects of dried fruits oil extract of Pterodon emarginatusin Caenorhabditis elegans

Cited by 12 publications

References 42 publications

The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

The Chemical Compositions of Essential Oils Derived from Cryptocarya alba and Laurelia sempervirens Possess Antioxidant, Antibacterial and Antitumoral Activity Potential

Protective effect of sucupira oil nanoemulsion against oxidative stress in UVA-irradiated HaCaT cells

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