Antioxidant and Immunotropic Properties of some Lithium Salts

Plotnikov, Evgenii; Voronova, Olesya; Linert, Wolfgang; Martemianov, Dmitrii; Короткова, Е. И.; Dorozhko, Elena V.; Асташкина, А. П.; Martemianova, Irina; Ivanova, Svetlana A.; Бохан, Н. А.

doi:10.7324/japs.2016.600115

Cited by 17 publications

(12 citation statements)

References 12 publications

(8 reference statements)

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“…Recent work showed excellent antioxidant activity of some organic lithium salt. 19 It depends mostly of anionic component. Lithium can change of intracellular pathways of apoptosis due to important role in mitochondrial function via inositol depletion.…”

Section: Resultsmentioning

confidence: 99%

Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells

et al. 2019

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Purpose: Aim of present work was to study cytoprotective properties of lithium pyruvate, as a prospective pharmacological agent. Pyruvate has a lot of potential benefits due to positive influence on cell metabolism. Lithium is "gold-standard" mood-stabilizer. Combination of both may lead advantages. Methods: Lithium pyruvate was tested as cytoprotector on human blood mononuclears under induced oxidative stress. Cells were obtained from healthy donors and patients with alcoholism. The detection of cell viability, apoptosis and determination of oxidative stress level were conducted by flow cytometry. Results: Lithium pyruvate showed excellent cytoprotective properties in normal and oxidation conditions. This effect was independent from cell donor health status. It was shown on cells from healthy donors and alcoholics patients. Conclusion: Obtained results allow considering lithium pyruvate as potential normothymic agents (mood stabilizer) with excellent cytoprotective properties.

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Section: Resultsmentioning

confidence: 99%

Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells

et al. 2019

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“…Він володіє антимікробними (Stachelska, 2015), антивірусними (Qian et. al., 2018), протипухлинними (Wu et al, 2013), антиметастатичними (Maeng et al, 2016), антистресовими (Galochkin et al, 2018), радіозахисними (Tarumov & Antushevich, 2013), імуномодулюючими (Lohitha & Singh, 2019) та антиоксидантними (Plotnikov et al, 2016) властивостями. Існують прямі клінічні докази впливу літію на остеогенез (Wang et al, 2015).…”

Section: вступunclassified

Development of digestive organs in goslings raised for meat, depending on lithium level in mixed feeds

2020

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Recently, the vital necessity of lithium for living organisms has been experimentally proven and also it was previously considered as a conditionally essential trace element. Numerous experimental research conducted on various animals and poultry types have revealed quite wide and diverse properties of lithium, in particular, antimicrobial, antiviral, antitumor, anti-stress and antioxidant. The discovery of biological properties and the disclosure of biochemical mechanisms of lithium action became the basis for its use in veterinary and zootechnical practice. Lithium preparations are successfully used to treat various animal diseases, prevent and correct “technological” stresses in poultry, increase its productive qualities and improve the quality of meat products. Despite the biochemical complexity and practical significance of this trace element, lithium is still insufficiently used during feeding poultry due to the lack of optimal standards for introducing it into mixed feed. During developing optimal standards for lithium introduction into mixed feed, it is necessary to evaluate not only the indicators of poultry productivity and product quality, but also the physiological indicators of its development. The effect of additives of different lithium doses in compound feeds on the development of digestive organs in goslings raised for meat was studied in a scientific-economic experiment. The research was conducted on the breed of goslings “Danish Legart”. The duration of experiment was 70 days. The lithium introduction into compound feeds for goslings, in doses of 0.15 mg/kg, 0.20 and 0.25 mg/kg, had a positive effect on the development of their digestive organs, as evidenced by the tendency to increase the intestine mass (by 2.2–4.8 %) and its total length (by 0.5–1.1 %), as well as an increase in the liver mass (by 2.0–7.0 %) and muscle stomach (by 3.4–7.3 %). Goslings had the best macromorphological indicators of digestive development, whose mixed feed were enriched with lithium at the rate of 0.15 mg/kg during the entire growing period. A comparison of goslings live weight of the experimental groups with indicators of the development of intestines, liver and muscular stomach allows to claim that their digestive organs were better developed and functioned more actively during the growing period.

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“…Выявленное в настоящем исследовании протекторное действие солей лития на биомолекулы плазмы крови, повреждённые этанолом, не коррелирует с антиоксидантной активностью этих соединений, определенной в работе [2], где антиоксидантную активность оценивали вольтамперометрическим методом в модельной системе по реакции электровосстановления кислорода, протекающей на катоде. Измеренная таким методом антиоксидантная активность исследуемых веществ уменьшалась в ряду аскорбат лития > пируват лития > карнозин = фумарат лития > сукцинат лития > карбонат лития.…”

Section: результаты и обсуждениеunclassified

“…Для проявления антиоксидантного действия соединениями лития (помимо нормотимического и нейропротекторного эффекта) можно использовать различные анионы. Ранее в модельной системе вольтамперометрическим методом было показано, что соли лития и аскорбиновой кислоты (аскорбат лития), янтарной кислоты (сукцинат лития), аспарагиновой кислоты (аспартат лития), яблочной кислоты (малат лития), бензойной кислоты (бензоат лития), глутаминовой кислоты (глутамат лития) обладают выраженной антиоксидантной активностью [2]. В этом ряду наибольшей антиоксидантной активностью обладает аскорбат лития, который в экспериментальных условиях продемонстрировал нейропротекторные [3], иммуномодулирующие [4] и гематопротекторные [5] свойства.…”

Section: Introductionunclassified

Protective action of carnosine and organic lithium salts in case of ethanol-induced oxidative damage of proteins and lipids of blood plasma in healthy persons and alcoholic patients

et al. 2019

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Organic lithium salts containing anionic components (succinate, fumarate, pyruvate and antioxidant ascorbate) were tested for protection of blood plasma proteins and lipids against ethanol-induced oxidation in vitro. We used normothymic lithium carbonate and well-known antioxidant dipeptide carnosine (b-alanyl-L-histidine) as the reference drugs. The oxidized proteins and lipids were determined by the level of carbonylated proteins (CP) and TBA-reactive products (TBA-RP), respectively. In alcoholic patients the level of oxidized proteins and lipids was higher than in healthy persons. Incubation of blood with ethanol resulted in an increase in oxidized proteins and lipids in blood plasma of healthy persons but had no influence on the level of CP and TBA-RP in blood plasma of alcoholic patients. Lithium carbonate, lithium ascorbate, and lithium succinate exhibited protective action against ethanol-induced oxidation of biomolecules of blood plasma of healthy people. These effects were comparable with carnosine action. The studied compounds had no effect on the level of CP and TBA-RP of blood plasma of alcoholic patients.

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Antioxidant and Immunotropic Properties of some Lithium Salts

Cited by 17 publications

References 12 publications

Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells

Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells

Development of digestive organs in goslings raised for meat, depending on lithium level in mixed feeds

Protective action of carnosine and organic lithium salts in case of ethanol-induced oxidative damage of proteins and lipids of blood plasma in healthy persons and alcoholic patients

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