Antioxidant and hepatoprotective potentials of curcuminoid isolates from turmeric (Curcuma longa) rhizome on CCl₄-induced hepatic damage in Wistar rats

Abstract

The present study examined the protective effects of curcuminoid isolates from Curcuma longa against carbon tetrachloride (CCL 4 )-induced hepatic injury in rats. The hepatoprotective effect of the crude extract (150, 300 and 600 mg/kg bw) and curcuminoids (75, 150 and 300 mg bw) was evident by significant increases in the serum antioxidative defence capacities (super oxide dismutase, reduced glutathione, catalase) and reduction in biomarker enzymes of liver integrity (aspartate transaminase, alanine transaminase and alkaline phosphatase) in comparison to the results obtained in the CCL 4 -untreated animals. Some of these parameters were completely restored by pre-treatments with curcuminoids. Similarly, the curcuminoids increases the concentrations of total proteins, albumins and ameliorated histological changes observed in CCL 4 injured rats. Therefore, curcuminoid could be considered a novel candidate for the development of new drug against liver diseases.

Computational and Preclinical Evidence of Anti‐ischemic Properties of L‐Carnitine‐Rich Supplement via Stimulation of Anti‐inflammatory and Antioxidant Events in Testicular Torsed Rats

“…Oxidative stress and an imbalance between the generation of prooxidant and antioxidant systems have been associated with several organ abnormalities [65][66][67] and implicated in ischemia-reperfusion-induced testicular impairments [44]. The increased ROS generation leads to oxidative stress and activates apoptosis and increased DNA damage.…”

Response of lymphatic tissues to natural feed additives, curcumin (Curcuma longa) and black cumin seeds (Nigella sativa), in broilers against Pasteurella multocida

“…Turmeric is used as a blood purifier and used in the prevention and treatment of skin diseases ( Ahmed et al., 2020 ). It was found that the main functions of Curcuma rhizome were hepatoprotective ( Sadashiva et al., 2019 ; Ibrahim et al., 2020 ), anti-inflammatory ( Tejada et al., 2016 ; Xiang et al., 2017 ), antimicrobial ( Singh et al., 2017 ; Ilangovan et al., 2018 ), antiviral ( Alsamydai and Jaber, 2018 ), antifungal ( Hu et al., 2017 ), wound healing ( Tejada et al., 2016 ), antitumour ( Shakeri et al., 2019 ), antivenom ( Sani et al., 2019 ), and immunomodulator ( Mehala and Moorthy, 2008 ). The results revealed the therapeutic potential of C. longa crude extracts, including polysaccharides and curcuminoids as a supportive supplement for cancer patients whose immune systems were crushed during chemotherapy.…”

In-silico investigation of curcumin drug-likeness, gene-targets and prognostic relevance of the targets in panels of human cancer cohorts

“…Curcumin, is a polyphenolic natural compound isolated from Curcuma longa, a reputable medicinal plants commonly known as turmeric [13]. Curcumin has been reported for several therapeutic activities against a number of diseases; including antioxidants, hepato-protective [14], anti-inflammatory and anticancer activities. Several literatures have emphasized the anti-antineoplastic properties of curcumin against experimental cell line and chemically induced carcinogenesis in animal models of cancer [15][16][17][18].…”