Antioxidant and Antiglycative Potential of Ethyl Acetate Fraction of Psidium guajava Leaf Extract in Streptozotocin-Induced Diabetic Rats

Soman, Sowmya; Rauf, Arun A.; Indira, M.; Rajamanickam, C.

doi:10.1007/s11130-010-0198-9

Cited by 55 publications

(33 citation statements)

References 25 publications

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“…It also showed an improved antioxidant potential as evidenced by decreased LPO and a significant increase in the activity of CAT, SOD, GPx and GSH. 37 The present study is also accordance with the previous study.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of Antioxidant Activity of Psidium guajava Linn. in streptozotocin–Induced Diabetic Rats

Manikandan

Anand

2016

FRA

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Background:The incidence of diabetes is increasing rapidly in world wide. It produces disturbances in the metabolism of carbohydrate, protein, and lipid. Evidences recommended that the natural medicines originating from plant source may represent a culturally relevant complementary treatment for diabetes. Objective: The aim of the present study is to investigate the antioxidant activities of the ethanolic leaf extract of Psidium guajava Linn. in streptozotocin (STZ) induced oxidative stress in rats. Methods: Oxidative stress is induced with a single dose of STZ 60 mg/kg b.w. and then the animals are treated with a dose of various concentrations of ethanolic leaf extract of P. guajava (100 mg/kg b.w, 200 mg/kg b.w, and 300 mg/ kg b.w) for 45 days. After the treatment, the glucose, lipid peroxides (LPO), reduce glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), urea and creatinine levels are determined. Glibenclamide is used as a standard drug (3 mg/kg b.w.). Results: The present study exposed that the administration of ethanolic leaf extract of P. guajava showed a significant decrease in glucose and LPO levels. The treatment also finds that the significant increase in GSH, GPx, SOD and CAT levels in the liver, when compared with diabetic control rats. Conclusion:The results proved that the ethanolic leaf extract of P. guajava treated group may effectively regulate the antioxidant status in STZ induced diabetic treated groups.

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Section: Discussionsupporting

confidence: 93%

Evaluation of Antioxidant Activity of Psidium guajava Linn. in streptozotocin–Induced Diabetic Rats

Manikandan

Anand

2016

FRA

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“…The guava leaves extracts also are a very good source of phenolic compounds such as gallic acid, ferrulic acid, quercetin and quercetin derived glycosides. The phenolic compounds of guava leaf extracts significantly decreased fasting blood glucose levels in streptozotocin-induced diabetic rats, decreased glycation products, lipid peroxidation and improved the antioxidant status in a dose-dependent manner [114]. Thus, the effect of guava leaves on glycation may be due to the different composition of the phenolic compounds.…”

Section: Flavones Flavonols Flavanones and Flavanonolesmentioning

confidence: 96%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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“…The mechanism of the hypoglycemic action of coumarins may be involved in hepatotoxicity [71]. The terpene trans-dehydrocrotonin (Figure 2B), which is classified as a lactone-type clerodane diterpene, showed antidiabetic activity in mice [72][73][74].…”

Section: Terpenesmentioning

confidence: 99%

“…Phenolic plant components play an important role in the prevention of diabetes complications by reducing the formation of reactive oxygen species, and protecting kidney function [73].…”

Section: Biological Activity Of Natural Plant Componentsmentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Antioxidant and Antiglycative Potential of Ethyl Acetate Fraction of Psidium guajava Leaf Extract in Streptozotocin-Induced Diabetic Rats

Cited by 55 publications

References 25 publications

Evaluation of Antioxidant Activity of Psidium guajava Linn. in streptozotocin–Induced Diabetic Rats

Evaluation of Antioxidant Activity of Psidium guajava Linn. in streptozotocin–Induced Diabetic Rats

Plant-Derived Agents with Anti-Glycation Activity

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

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