Evaluation of Antioxidant Activity of Psidium guajava Linn. in streptozotocin–Induced Diabetic Rats

Manikandan, R.; Anand, Arumugam Vijaya

doi:10.5530/fra.2016.1.9

Cited by 18 publications

(7 citation statements)

References 28 publications

(18 reference statements)

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“…This implies that the extract was able to protect against Aluminium-induced oxidative stress. This is in line with previous studies demonstrating that Psidium guajava boosts the activities of antioxidant enzymes and inhibits lipid peroxidation (Manikandan and Anand, 2016;Fatoki et al, 2022). Histological findings of the control group showed normal histology of the prefrontal cortex.…”

Section: Discussionsupporting

confidence: 92%

Aluminium chloride-induced prefrontal cortex toxicity in Wistar rats: evidence from pretreatment with aqueous <i>Psidium guajava</i> leaf extract

Usen,

Enogieru

2023

dujopas

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Aluminium is reported to be a very common element and one of the most abundant metals on Earth. Although aluminium is neurotoxic and linked to several brain disorders, reports indicate that antioxidants from natural sources can neutralise the toxic free radicals generated by aluminium. Consequently, this study evaluated the protective and antioxidative effects of Psidium guajava (GV) aqueous leaf extract on Aluminium-induced prefrontal cortex toxicity. Thirty (30) adult Wistar rats in six (6) groups were used for this experiment (n=5): Group A (control); Group B rats (Al) were given 100 mg/kg body weight (BW) of Aluminium alone; Group C (Al + GV1) rats were given 100 mg/kg BW of Aluminium and 200mg/kg BW/day of aqueous GV leaf extract; Group D (Al + GV2) was administered 100 mg/kg BW of Al and 400 mg/kg BW of aqueous GV leaf extract; Group E (GV1) was administered 200 mg/kg BW of aqueous GV leaf extract alone and Group F (GV2) was administered 400 mg/kg BW of aqueous GV leaf extract alone. Following the end of administration, neurobehavioral, antioxidant enzymes, and prefrontal cortex histology assessments were done. Findings showed that Group B rats had a significant (p<0.05) decrease in final body and absolute brain weights, and antioxidant enzymes activity when compared to control. Likewise, a significant (p<0.05) decrease was observed in spontaneous alternation in rats treated with Al alone, thus indicating cognitive dysfunction. Conversely, following pretreatment with Psidium guajava, the alterations induced by Al were mitigated. Taken together, Psidium guajava showed a potent capability as a possible neuroprotective agent that can be useful for inhibiting Al-induced neurotoxicity and cognitive dysfunctions. Further investigations and development of this plant could offer a worthwhile substitute to other orthodox drugs currently used in the treatment and/or management of aluminium-related disorders.

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Section: Discussionsupporting

confidence: 92%

Aluminium chloride-induced prefrontal cortex toxicity in Wistar rats: evidence from pretreatment with aqueous <i>Psidium guajava</i> leaf extract

Usen,

Enogieru

2023

dujopas

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“…Due to antioxidant activity of guava it can control the diabetes. It shows a significant diabetic control in mice [68].…”

Section: Antioxidant Activitymentioning

confidence: 92%

“…The antioxidative potential of guava extracts has rendered a new therapeutic path against the various complications and diseases. Further investigations are required in this regard to find the actual mechanism involved in antioxidant and other pharmacological activities of guava [73].…”

Section: Antioxidant Activitymentioning

confidence: 99%

The phytochemistry and medicinal value of Psidium guajava (guava)

et al. 2018

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Psidium guajava (guava) is well known tropic tree which is abundantly grown for fruit. Many countries have a long history of using guava for medicinal purposes. This plant finds applications for the treatment of diarrhea, dysentery, gastroenteritis, hypertension, diabetes, caries and pain relief and for improvement in locomotors coordination. Its leaf's extract is being used as a medicine in cough, diarrhea, and oral ulcers and in some swollen gums wound. Its fruit is rich in vitamins A, C, iron, phosphorus and calcium and minerals. It contains high content of organic and inorganic compounds like secondary metabolites e.g. antioxidants, polyphenols, antiviral compounds, anti-inflammatory compounds. The phenolic compounds in guava help to cure cancerous cells and prevent skin aging before time. The presence of terpenes, caryophyllene oxide and p-selinene produces relaxation effects. Guava leaves contain many compounds which act as fungistatic and bacteriostatic agents. Guava has a high content of important antioxidants and has radio-protective ability. Quercetin is considered as most active antioxidant in the guava leaves and is responsible for its spasmolytic activity. Its ethyl acetate extract can stop the germ infection and thymus production. Guava possesses anti-viral, anti-inflammatory, anti-plaque and anti-mutagenic activities. Guava extract shows antinociceptive activity and is also effective in liver damage inflammation and serum production. Ethanolic extract of guava can increase the sperm quality as well as quantity and can be used for the treatment of infertile males.

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“…P. guajava is cultivated throughout India, mostly in the states of Andhra Pradesh, Assam, Bihar, Maharashtra, Uttar Pradesh, and West Bengal (Daswani et al, 2017). Leaves of the plant contain a large number of phytoconstituents, such as alkaloids, terpenoids, phenols, flavonoids, and ethanol extracts (Manikandan et al, 2013(Manikandan et al, , 2016Manikandan and Vijaya Anand, 2015). Zakaria and Mohd (1994) established that the leaves of P. guajava contained caryophyllene, alpha-pinene, quercetin, and limonene compounds.…”

Section: Introductionmentioning

confidence: 99%

Impact on cardioprotective effect of Psidium guajava leaves extract in streptozotocin-induced Wistar mice with molecular in silico analysis

Manikandan

Balasubramanian

Boro

et al. 2023

Qual. Assur. Saf. Crops Foods

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Cardiovascular disease (CVD) and its complications have been regarded as the leading cause of morbidity and mortality. The drugs available in the market are effective to treat CVD, but with many adverse reactions. Nowadays, herbal products are the attention of researchers because of their less adverse effects. In this study, the cardioprotective effects of ethanolic leaves extract of Psidium guajava Linn. (Guava) (P. guajava) were evaluated in streptozotocin (STZ)-treated animal models. Mice acquired for the study were divided into five groups, each consisting of six mice. The toxin-induced mice were treated with the ethanolic leaves extract of P. guajava (300 mg/kg body weight [b.w.]). The results were compared to the standard drug (glibenclamide)-treated mice (3 mg/kg b.w.). The following parameters were considered for further investigations: creatine kinase-muscle brain (CK-MB), creatine kinase (CK), troponin, lysosomal, and mitochondrial enzymes. Then the docking study was accomplished. The levels of cardiac marker enzymes and lysosomal enzymes increased significantly in the toxin-induced mice, while the level of mitochondrial enzyme decreased significantly. During treatment with the ethanolic leaves extract of P. guajava, the levels of all parameters were notably reversed to normal range (P < 0.05). Further, in docking analysis, the interaction of compounds, such as alpha-terpineol, cyclopentanecarboxamide, guaiol (a sesquiterpenoid alcohol), 1H-cyclopropanaphthalene, tetracyclotridecan-9-ol, dormin/abscisic acid, and epiglobulol, with the respective protein molecules, evidenced the cardioprotective effect of P. guajava leaves. Hence, it was concluded that the ethanolic leaves extract of P. guajava leaves have a cardioprotective effect.

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Evaluation of Antioxidant Activity of Psidium guajava Linn. in streptozotocin–Induced Diabetic Rats

Cited by 18 publications

References 28 publications

Aluminium chloride-induced prefrontal cortex toxicity in Wistar rats: evidence from pretreatment with aqueous <i>Psidium guajava</i> leaf extract

Aluminium chloride-induced prefrontal cortex toxicity in Wistar rats: evidence from pretreatment with aqueous <i>Psidium guajava</i> leaf extract

The phytochemistry and medicinal value of Psidium guajava (guava)

Impact on cardioprotective effect of Psidium guajava leaves extract in streptozotocin-induced Wistar mice with molecular in silico analysis

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