Antioxidant and Anticancer Activities of Methanol Extract of Seeds of Datura stramonium l

Iqbal, Saleem; Sivaraj, C; Gunasekaran, Krishnasamy

doi:10.5530/fra.2017.2.28

Cited by 29 publications

(27 citation statements)

References 12 publications

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“…The ANOVA using the Dunnett Test showed that the antiradical activities of our bark extracts (p-value = 0.004 < 0.05) and leaves (p-value = 0.0001 < 0.05) are all lower than those of the positive controls tested: ascorbic acid with 3.05 ± 0.07 µg/ml, rutin with 2.79 ± 0.79 µg/ml and quercetin with 1.17 ± 0.03 µg/ml (Figure 4.). The high content of polyphenols and flavonoids (Figure 2) in the extracts would be responsible for the anti-free radical activities observed in our extracts; since a direct correlation between antioxidant activity and the reducing power of plant extracts involving phenolic compounds has been reported by many authors (Fatima et al, 2015;Iqbal et al, 2017;Togola et al, 2019;Fofié et al, 2017;Bagewadi et al, 2019). Other secondary metabolites (tannins, terpenes, sterols, etc.…”

Section: Discussionsupporting

confidence: 58%

Evaluation of the biological activities of leaf and bark extracts of Ficus platiphylla Delile, a medicinal plant used in Mali

KonarÃ¹,

Diarra²,

CissÃ³

et al. 2020

J. Med. Plants Res.

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Leaves and barks of Ficus platiphylla are used in traditional medicine in western Africa for treating bacterial infections. The aim of this work was to screen the biological activities of extracts of the plant. Three common bacterial strains were used in this study. The antiradical and antibacterial activities were assessed respectively by spectrophotometric and agar diffusion methods. The bark and leaves are very rich in dry matter, ash and as well as proteins and carbohydrates. Ethyl acetate was the best solvent to extract polyphenols (4.77-5.01 g/100 g) and flavonoids (1.97-3.32 g/100 g). Similarly, ethyl acetate extracts showed the best anti-free radical activity with IC 50 = 5.10 and 5.22 µg/ml for bark and leaves respectively. The aqueous and methanolic leaf extracts displayed the highest antibacterial activity on the Escherichia coli, with an inhibition diameter (ID) of 11.50 ± 0.50 mm. On Salmonella typhi, the most active antibacterial agents were found in leaf ethyl acetate extracts with ID = 15.33 ± 0.58 mm. These extracts have the same efficacy as the commercial antibiotic ciprofloxacin (positive control) which displayed an ID of 15.33 ± 0.76 mm. Finally, S. aureus was highly sensitive to ethyl acetate extracts of the barks: ID = 15.50 ± 1.32 mm (p-value = 4.10E-6 < 0.05). The richness in secondary metabolites associated with the antiradical and antibacterial activities justify use of F. platiphylla in traditional medicine. This study shows that F. platiphylla could be a valuable medicinal plant for the management of common bacterial infections.

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Section: Discussionsupporting

confidence: 58%

Evaluation of the biological activities of leaf and bark extracts of Ficus platiphylla Delile, a medicinal plant used in Mali

KonarÃ¹,

Diarra²,

CissÃ³

et al. 2020

J. Med. Plants Res.

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“…[4][5] The medicinal properties of traditional medicinal plants have been investigated in the recent scientific developments for treatment of many metabolic diseases. The extract of these plants from various places in the world are reported to possess several pharmacological activities including anti-inflammatory, [6][7] antidiabetic, [8][9][10][11] antimalarial, 12 antimicrobial, [13][14] anti TB, 15 anthelmintic activity, 16 anticancer, [17][18] cylindroxanthones A-C (1-3 etc. Traditional medicinal plants derived natural product such as alkaloids, flavonoids and terpenes.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Capacity of Some Selected Medicinal Plants in East Nusa Tenggara, Indonesia: The Potential of Sterculia quadrifida R.Br.

Lulan¹,

Fatmawati

Santoso

et al. 2018

FRA

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Background:Medicinal plants derived natural product such as alkaloids, flavonoids and terpenes. The traditional uses claim that medicinal plants of NTT are potential folk medicine but very little research has been conducted on these plants. Objective: The present study is directed towards evaluating naturally effective antioxidant of twenty-four traditional medicinal plants collected from Kupang, East Nusa Tenggara (NTT) using in vitro models. Method: The antioxidant activities were determined by using the free radical scavenging assays 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2-2"-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Analysis of total flavonoid and phenolic contents were expressed as Quercetin Equivalent (QE) and Gallic Acid Equivalent (GAE), respectively. Statistical methods are used in data analysis include mean or standard deviation, and regression analysis. Result: Methanol extract of Sterculia quadrifida R. Br. root exhibited the highest DPPH radical scavenging activity with IC 50 value of 3.11μg/mL, followed by Schleichera oleosa and Euphorbia hirta L. extracts with IC 50 values of 10.05 and 10.09 μg/mL, respectively. Methanol extract of S. quadrifida also showed highest ABTS radical scavenging activity with IC 50 value of 7.29 μg/mL, followed by Eugenia jambolana Lam. and Lamea grandus with IC 50 value of 9.15 and 12.29 μg/mL, respectively. S. quadrifida extract showed high flavonoid and phenolic content with 661.85 mg of GAE and 116.84 mg of QE per 100 g of extracts. Conclusion: The present study gives scientific evidences that twenty four samples of NTT plants have high free radical scavenging capacity. Strong radical scavenging activity of these plants especially S. quadrifida could be considered as a potential source of natural antioxidants.

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“…The findings obtained are shown in Table 2. In previous studies, it was reported that petroleum ether, benzene, solvent ether, chloroform, acetone, ethanol and methanol extracts of D. stramonium had antioxidant potential with different methods (DPPH radical scavenging assay, Superoxide radical scavenging assay, ABTS + radical cation scavenging assay, Hydroxyl (OH) radical scavenging assay, Nitric oxide (NO) radical scavenging assay, Ferric (Fe3 +) reducing power assay, Phosphomolybdenum reduction assay) (Kumar et al, 2008;Sreenivasa et al, 2012;Iqbal et al , 2017;Belayneh et al, 2019). In our study, the antioxidant potential of EtoH extract of D. stramonium was determined for the first time using TAS and TOS kits.…”

Section: Antioxidant and Oxidant Statusmentioning

confidence: 99%

Datura stramonium (Solanaceae): Antioxidant and Antimicrobial Potentials

Mohammed

Kına

Sevindik

et al. 2021

Turkish JAF Sci.Tech.

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Many people in different parts of the world benefit from alternative medicine in the treatment and prevention of diseases. Plants are among the important natural materials used in alternative medicine. In this study, the antioxidant and antimicrobial potential of Datura stramonium L. was determined. Ethanol extracts of the plant's flower parts were obtained in the soxhlet device. The antioxidant and oxidant potential of the plant extract was determined using Rel Assay TAS and TOS kits. Antimicrobial activity was tested by the agar dilution method. The TAS value of the plant extract was 7.559±0.224 mmol/L, the TOS value was 10.711±0.243 μmol/L, and the OSI value was 0.142±0.002. It was determined that the plant extract was effective against bacteria and fungus strains at 100-400 μg/mL concentration. As a result, it was determined in our study that D. stramonium can be a natural antioxidant and antimicrobial source.

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Antioxidant and Anticancer Activities of Methanol Extract of Seeds of Datura stramonium l

Cited by 29 publications

References 12 publications

Evaluation of the biological activities of leaf and bark extracts of Ficus platiphylla Delile, a medicinal plant used in Mali

Evaluation of the biological activities of leaf and bark extracts of Ficus platiphylla Delile, a medicinal plant used in Mali

Antioxidant Capacity of Some Selected Medicinal Plants in East Nusa Tenggara, Indonesia: The Potential of Sterculia quadrifida R.Br.

Datura stramonium (Solanaceae): Antioxidant and Antimicrobial Potentials

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