Antioxidant and Antibacterial Properties of Extracts and Bioactive Compounds in Bryophytes

Cianciullo, Piergiorgio; Maresca, Viviana; Sorbo, Sergio; Basile, Adriana

doi:10.3390/app12010160

Cited by 14 publications

(9 citation statements)

References 91 publications

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“…In Maresca et al [ 65 ] non-enzymatic antioxidant-defence enhancement was observed as an increase in the total phenolic content and lunularic acid synthesis in the liverwort C. conicum exposed (7 days) to a mix of heavy metals such as Cu, Zn, Pb and Cd. Lunularic acid is a bibenzyl, an abundant group of molecules in liverworts [ 73 , 74 ], which serve as the precursor molecule for the synthesis of other bibenzyls and bis-bibenzyls. The synthesis of lunularic acid starts from phenylalanine [ 75 ].…”

Section: Bryophytes and Heavy Metalsmentioning

confidence: 99%

Non-Protein Thiol Compounds and Antioxidant Responses Involved in Bryophyte Heavy-Metal Tolerance

Salbitani

Maresca

Cianciullo

et al. 2023

IJMS

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Heavy-metal pollution represents a problem which has been widely discussed in recent years. The biological effects of heavy metals have been studied in both animals and plants, ranging from oxidative stress to genotoxicity. Plants, above all metal-tolerant species, have evolved a wide spectrum of strategies to counteract exposure to toxic metal concentrations. Among these strategies, the chelation and vacuolar sequestration of heavy metals are, after cell-wall immobilization, the first line of defence that prevent heavy metals from interacting with cell components. Furthermore, bryophytes activate a series of antioxidant non-enzymatic and enzymatic responses to counteract the effects of heavy metal in the cellular compartments. In this review, the role of non-protein thiol compounds and antioxidant molecules in bryophytes will be discussed.

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Section: Bryophytes and Heavy Metalsmentioning

confidence: 99%

Non-Protein Thiol Compounds and Antioxidant Responses Involved in Bryophyte Heavy-Metal Tolerance

Salbitani

Maresca

Cianciullo

et al. 2023

IJMS

Self Cite

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“…The indirect antioxidants inhibit the interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2) that resulted in the release of Nrf2, its phosphorylation, and translocation in nucleus when Nrf2 combines with one of the small Maf proteins (sMaf) and binds to the antioxidant response element (ARE) in the upstream promoter region of many antioxidative genes, and initiates their transcription resulted in overexpression of superoxide dismutase (SOD), catalase (CAT), NAD(P)H dehydrogenase (quinone) 1 (NQO1), γ-glutamylcysteine synthetase (GCS), and others. [29]. The indirect antioxidants inhibit the interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2) that resulted in the release of Nrf2, its phosphorylation, and translocation in nucleus when Nrf2 combines with one of the small Maf proteins (sMaf) and binds to the antioxidant response element (ARE) in the upstream promoter region of many antioxidative genes, and initiates their transcription resulted in overexpression of superoxide dismutase (SOD), catalase (CAT), NAD(P)H dehydrogenase (quinone) 1 (NQO1), γ-glutamylcysteine synthetase (GCS), and others.…”

Section: Discussionmentioning

confidence: 99%

The Kelch/Nrf2 Antioxidant System as a Target for Some Marine Fungal Metabolites

Yurchenko,

Khmel,

Nesterenko

et al. 2023

Oxygen

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Marine fungal metabolites often exhibit antioxidant activity, but their effects on the Keap1/Nrf2 cellular system are rarely studied, possibly due to insufficient isolated amounts. In this work, we used a bioinformatics approach to evaluate the ability of some promising cytoprotective compounds to bind Kelch domain of Keap1 protein, and thus inhibit its interaction with Nrf2. The molecular docking data suggested that gliorosein, niveoglaucin A, 6-hydroxy-N-acetyl-β-oxotryptamine, 4-hydroxyscytalone and 4-hydroxy-6-dehydroxyscytalone can form the hydrogen building with Arg415 or Arg483 amino acid residues of P1-P2 sub-pockets in the Nrf2 binding site of Keap1′s Kelch domain. These positions of the small molecules in the Kelch domain of Keap1 can inhibit the interaction of Keap1 with Nrf2 and enhance the nuclear translocation of Nrf2 from cytosol that can result in overexpression of relative genes. This assumption, based on virtual screening of a number of low molecular weight metabolites of marine fungi, makes them promising for further studies.

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“…Metabolites such as marchantin A, plagochilin E, and riccardin C exhibit cytotoxic activities against chemoresistant prostate cancer [3,100]. In addition to the aforementioned active compounds, those with antioxidant [135][136][137], anti-inflammatory [138][139][140], psychoactive [111], antiviral [141], muscle-relaxing [142], neuroprotective [142,143], anti-HIV [144], and insecticidal activities can be distinguished [145,146]. Compounds with nematicidal activity have potential in agricultural industry as natural plant-protection products.…”

Section: Discussionmentioning

confidence: 99%

Modern Use of Bryophytes as a Source of Secondary Metabolites

et al. 2022

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Bryophytes constitute a heterogeneous group of plants which includes three clades: approximately 14,000 species of mosses (Bryophyta), 6000 species of liverworts (Marchantiophyta), and 300 species of hornworts (Anthocerotophyta). They are common in almost all ecosystems, where they play important roles. Bryophytes lack developed physical barriers, yet they are rarely attacked by herbivores or pathogens. Instead, they have acquired the ability to produce a wide range of secondary metabolites with diverse functions, such as phytotoxic, antibacterial, antifungal, insect antifeedant, and molluscicidal activities. Secondary metabolites in bryophytes can also be involved in stress tolerance, i.e., in UV-absorptive and drought- and freezing-tolerant activities. Due to these properties, for centuries bryophytes have been used to combat health problems in many cultures on different continents. Currently, scientists are discovering new, unique compounds in bryophytes with potential for practical use, which, in the age of drug resistance, may be of considerable importance. The aim of this review is to present bryophytes as a potential source of compounds with miscellaneous possible uses, with a focus on volatile compounds and antibacterial, antifungal, and cytotoxic potential, and as sources of materials for further promising research. The paper also briefly refers to the methods of compound extraction and acquisition. Formulas of compounds were drawn by the authors using ChemDraw software (PerkinElmer, Boston, MA, USA) with reference to data published in various papers, the ACD/Labs dictionary database, PubChem, and Scopus. The data were gathered in February 2022.

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Antioxidant and Antibacterial Properties of Extracts and Bioactive Compounds in Bryophytes

Cited by 14 publications

References 91 publications

Non-Protein Thiol Compounds and Antioxidant Responses Involved in Bryophyte Heavy-Metal Tolerance

Non-Protein Thiol Compounds and Antioxidant Responses Involved in Bryophyte Heavy-Metal Tolerance

The Kelch/Nrf2 Antioxidant System as a Target for Some Marine Fungal Metabolites

Modern Use of Bryophytes as a Source of Secondary Metabolites

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