The Kelch/Nrf2 Antioxidant System as a Target for Some Marine Fungal Metabolites
Ekaterina A. Yurchenko,
Olga O. Khmel,
Liliana E. Nesterenko
et al.
Abstract:Marine fungal metabolites often exhibit antioxidant activity, but their effects on the Keap1/Nrf2 cellular system are rarely studied, possibly due to insufficient isolated amounts. In this work, we used a bioinformatics approach to evaluate the ability of some promising cytoprotective compounds to bind Kelch domain of Keap1 protein, and thus inhibit its interaction with Nrf2. The molecular docking data suggested that gliorosein, niveoglaucin A, 6-hydroxy-N-acetyl-β-oxotryptamine, 4-hydroxyscytalone and 4-hydro… Show more
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