Antioxidant and antibacterial constituents from Morus nigra

Mazimba, Ofentse; Majinda, Runner R. T.; Motlhanka, Daniel Dan

doi:10.5897/ajpp11.260

Cited by 55 publications

(48 citation statements)

References 12 publications

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“…Its root, twigs, bark and fruits contain phenolic compounds used to treat asthma. Studies have reported that the plant is rich in isoprenylated flavonoids, triterpenes and saponins, which have antioxidant, antibacterial and anticancer activities [6][7][8]. Ziziphus mauritiana (local name: Ber) is a fruit tree which belongs to family Rhamnaceae.…”

Section: Introductionmentioning

confidence: 99%

Anti-leishmanial and cytotoxic activities of extracts from three Pakistani plants

Iqbal¹,

Iqbal²,

Umair³

et al. 2016

Trop. J. Pharm Res

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Purpose: To evaluate the in vitro and in vivo anti-leishmanial and cytotoxic activities of extracts of different parts of Lawsonia Inermis, Morus nigra and Ziziphus mauritiana. Methods: The methanol extracts of all three plant materials at concentrations of 10 -100 µg/mL were tested for their in vitro anti-leishmanial effects on L. tropica KWH23 promastigotes for 24 -48 h, relative to negative control and amphotericin-B (standard drug). For in vivo anti-leishmanial activity, the extracts were tested against L. tropica-infected albino mice, while cytotoxicity was investigated against mammalian cells (lymphocytes). Results: For Lawsonia Inermis leaves, mean inhibition of extracellular promastigotes at

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Section: Introductionmentioning

confidence: 99%

Anti-leishmanial and cytotoxic activities of extracts from three Pakistani plants

Iqbal¹,

Iqbal²,

Umair³

et al. 2016

Trop. J. Pharm Res

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“…It is commonly as Black Mulberry (English) and Shah-toot (Hindi/Urdu). Pharmacologically it has been reported that M. nigra is anti-oxidant (Ozgenet al, 2009), anti-nociceptive (Padil-ha et al, 2009, anti-inflammatory (Padilha et al, 2010), antidiabetic (Husseinzadeh et al, 1999, anti-bacterial (Mazimba et al, 2011), cardiac depressant , effective for maternal health (Volpetoet al, 2011), vermifuge and anti-cancer (Kumar and Chauhan, 2008 Important phytoconstituents e.g. flavonoids, alkaloids and phenols have been reported in this plant Özgen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective activity of aqueous methanolic extract of <i>Morus nigra</i> against paracetamol-induced hepatotoxicity in mice

Mallhi

Qadir

Khan

et al. 2014

Bangladesh J Pharmacol

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Morus nigra (Family Moraceae) is traditionally used injaundice, diabetes, hypertension, cough, fever and cancer. The current study was conducted to determine hepatoprotective activity of aqueous methanolic extract of leaves of M. nigra. Two doses of 250 mg/kg p.o and 500 mg/kg p.o showed that extract of M. nigra produced significant (p<0.001) reduction in liver enzymes (ALT, AST, ALP) and total bilirubin induced by paracetamol and the results are comparable to silymarin (p<0.001). Results were supported by histopathological investigations, phytochemical screening and detection of active constituents by HPLC. The current study showed that aqueous methanolic extract of M. nigra possess hepatoprotective activity that might be due to quercetin, luteolin and isorhamnetin. It was concluded from this study that M. nigra has hepatoprotective activity against paracetamol induced liver injury in mice. Article Info

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“…Bacillus subtilis, Micrococus flavus, Streptococcus faecal, Staphylococcus aureus, Eschericia coli, and Pseudomonas aeruginosa. 4,10 Previous studies showed that the ethanol extract of Morus nigra fruit has activity against Propionibacterium acnes (MIC 2.5 %) and Staphylococcus epidermidis (MIC 2.5 %).…”

Section: Introductionmentioning

confidence: 99%

“…There are several compounds that have been studied on Morus nigra L, such as fenol, flavonoid (kuwanon E and kuwanon U, and morusin), chalcone, 1-deoxynojirimycin. 3,4,5,6 Empirically in China, black mulberry plants are often used to decrease blood pressure, anti-hyperglycemic, diuretic, antioxidant, anthelmintic, anti-parasitic and antibacterial. 6,7,8,9 Black mulberry was known could inhibit bacterial i.e.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antibacterial Activity, and Mode of Action on Morus nigra

Aulifa¹,

Fitriansyah²,

Ardiansyah³

et al. 2017

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Introduction:The Morus nigra (Moraceae) known as black mulberry is a well-grown plant in Lembang, Indonesia. Previous studies showed that black mulberry fruit has activity as antibacterial and antioxidant. The aims of this study were to evaluate the antibacterial effect of ethanol extract from stem bark, fruit, and leaves of Morus nigra, MIC and morphological changes of the most active extract against Staphylococcus epidermidis and Propionibacterium acnes. Methods: Agar diffusion and microdilution assays were used to evaluate the antibacterial effect of the extract by measuring the zone of inhibition and the minimum inhibitory concentration (MIC) of the extract against the test bacteria. Scanning electron microscopy (SEM) was performed to evaluate the morphological changes induced by the extract in cellular membrane of the bacteria. Protein and ion leakage from the bacterial cells induced by the extract were also evaluated. Results: The antibacterial activity showed the most active extract was an ethanol extract of the stem bark against S. epidermidis and P. acnes with MIC value 4 mg/ml and 2 mg/ml, respectively. The extract also induced protein and ion leakage in test bacterial cells. SEM findings revealed that the extract induced potential cellular membrane damage in 4xMIC. Conclusion: The antibacterial activity was related to the damaged of bacterial cell wall.

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Antioxidant and antibacterial constituents from Morus nigra

Abstract: The objective of this study was to isolate and characterize the constituents of the local Morus nigra L.

Cited by 55 publications

References 12 publications

Anti-leishmanial and cytotoxic activities of extracts from three Pakistani plants

Anti-leishmanial and cytotoxic activities of extracts from three Pakistani plants

Hepatoprotective activity of aqueous methanolic extract of <i>Morus nigra</i> against paracetamol-induced hepatotoxicity in mice

Phytochemical Screening, Antibacterial Activity, and Mode of Action on Morus nigra

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