Antioxidant and anti-inflammatory properties of taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds

Chiu, Chuan Sung; Deng, Jeng Shyan; Chang, Heng Yuan; Chen, Yi-Chuan; Lee, Min Min; Hou, Wen Chi; Lee, Chao Ying; Huang, Szu-Wei; Huang, Guan Jhong

doi:10.1016/j.foodchem.2013.04.031

Cited by 74 publications

(50 citation statements)

References 24 publications

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“…The 70% hydro-methanol extract was previously demonstrated by other group of researchers to possess high amount of phenolic and flavonoid contents which contributed to its free radical scavenging activities (Das et al 2012). The presence of gallic acid, syringic acid, PCA, and myricetin has been previously identified in other plants of the Dioscorea genus (Fritzemeier & Kindi 1984;Kindl 1985;Gao et al 1997;Zuo 2002;Theerasin & Baker 2009;Chiu et al 2013;Das et al 2014). However, the present study for the first time (Figure 4) revealed the presence of different bioactive phenolics in the D. alata tuber.…”

Section: Discussionmentioning

confidence: 78%

“…(Jin et al 2010), D. villosa (Lima et al 2013), D. japonica Thunb. (Chiu et al 2013) and D. trifida L.f. (Mollica et al 2013) have already demonstrated antiinflammatory activities. Different bioactive constituents were also identified in the tubers such as gallic acid and vanillic acid in D. japonica (Chiu et al 2013), diosgenin and allantonin in D. trifida (Mollica et al 2013), and diosgenin D. villosa (Lima et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…(Chiu et al 2013) and D. trifida L.f. (Mollica et al 2013) have already demonstrated antiinflammatory activities. Different bioactive constituents were also identified in the tubers such as gallic acid and vanillic acid in D. japonica (Chiu et al 2013), diosgenin and allantonin in D. trifida (Mollica et al 2013), and diosgenin D. villosa (Lima et al 2013). However, D. alata has never been evaluated for the same in spite of the fact that the tubers are consumed extensively and also has been claimed to possess anti-inflammatory properties in traditional medicine (Khare 2007).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of anti-inflammatory activity and standardisation of hydro-methanol extract of underground tuber ofDioscorea alata

Dey

Chowdhuri

Sarkar

et al. 2016

Pharmaceutical Biology

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Context The underground edible tuber of Dioscorea alata L. (Dioscoreaceae) is a functional food with high nutritive value and therapeutic potential. The tuber is known to possess antiinflammatory properties in traditional medicine. Objective The present study explores the anti-inflammatory activity and standardisation of D. alata tuber hydromethanol extract. Materials and methods Hydromethanol extract (70%) of D. alata tuber was chemically characterised using HPLC and GC-MS techniques. Murine lymphocytes were cultured for 48 h with six different concentrations (0-80 mg/mL) of the extract. The expression of nitric oxide (NO), TNF-a, COX-1, COX-2, and PGE 2 were evaluated using colorimetric and ELISA methods. Results Dioscorea alata extract inhibited the expression of NO and TNF-a with an IC 50 value of 134.51 ± 6.75 and 113.30 ± 7.44 mg/mL, respectively. The IC 50 values for inhibition of total COX, COX-1, COX-2 activities and PGE 2 level were 41.96 ± 3.07, 141.41 ± 8.99, 32.50 ± 1.69, and 186.34 ± 15.36 mg/mL, respectively. Inhibition of PGE 2 level and COX-2 activity was positively correlated (R 2 ¼ 0.9393). Gallic acid (GA), 4-hydroxy benzoic acid (4HBA), syringic acid (SYA), p-coumaric acid (PCA), and myricetin (MY) were identified and quantified using HPLC. GC-MS analysis revealed the presence of 13 different phytocompounds such as hexadecanoic acid, methyl stearate, cinnamyl cinnamate, and squalene. Conclusion The D. alata extract significantly down-regulated the pro-inflammatory signals in a gradual manner compared with control (0 mg/mL). Different bioactive phytocompounds individually possessing anti-inflammatory activities contributed to the overall bioactivity of the D. alata tuber extract. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of anti-inflammatory activity and standardisation of hydro-methanol extract of underground tuber ofDioscorea alata

Dey

Chowdhuri

Sarkar

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…The measurement methods were based on the modifications of previous reports (Liu et al 2009;Chiu et al 2013). Briefly, MDA content was measured by the thiobarbituric acid reaction using a commercial kit.…”

Section: Measurement Of Mda No and Sodmentioning

confidence: 99%

“…The vascular endothelial system as the largest endocrine organ in the human body plays an important role in maintaining body homeostasis (Li et al 2013). Free radicals or reactive oxygen species (ROS) induce oxidative stress and enhance oxidative damage after diverse stimuli, which has been confirmed to be an initial event in the development of many diseases such as cardiovascular (Xu & Huang 2007;Liu et al 2009), inflammatory (Chiu et al 2013), diabetic (Duarte et al 2015), neurologic damage (Zhang et al 2015) and lipid peroxidation of biofilm (Qiu et al 2014). ROS may be a key factor in the organ injury such as brain and uterus because increased ROS is associated with the decrease in total antioxidant capacity and the significant increase in DNA damage (Kontos 2001;Shu et al 2013;Singh et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity of Typha angustifolia extracts and two active flavonoids

Chen

Cao

Bao

et al. 2017

Pharmaceutical Biology

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Context: The pollen of Typha angustifolia L. (Typhaceae) has been used as a traditional Chinese medicine for improving the microcirculation and promoting wound healing. Flavonoids are the main constituent in the plant, but little is known about the antioxidant activity of the principal constituent of the pollen in detail. Objectives: To assess the antioxidant activities of ethanol and water extracts and two constituents of the pollen. Materials and methods: Plant material (1 g) was extracted by 95% ethanol and water (10 mL Â 2, 1 h each), respectively. The extracted activities (0.8-2.6 mg/mL) were measured by DPPH and the reducing activity of ferric chloride (1.7-2.6 mg/mL). Typhaneoside and isorhamnetin-3-O-neohesperidoside (I3ON) (2.8-70 lmol/L) were investigated on the relationship between NO, MDA and SOD in HUVECs treated with 100 lg/mL of LPS for 24 h. Results: Nine compounds were identified by UPLC-MS. Ethanol extract showed IC 50 values in DPPH (39.51 ± 0.72) and Fe 3þ reducing activity (82.76 ± 13.38), higher than the water extract (50.85 ± 0.74) and (106.33 ± 6.35), respectively. Typhaneoside and I3ON promoted cell proliferation at the respective concentration range of 2.8 to 70 lmol/L (p < 0.01). This two compounds decreased MDA (1.91 ± 0.10, 1.80 ± 0.34, p < 0.05) and NO levels (14.64 ± 0.08, 13.10 ± 0.88, p < 0.01), respectively, and increased SOD level (22.94 ± 2.48, 23.57 ± 2.38, p < 0.01) at the concentration of 70 lmol/L compared with LPS group. Conclusions: The constituents from Typha angustifolia could be a novel therapeutic strategy for LPSinduced inflammation. ARTICLE HISTORY

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Dioscin: A review on pharmacological properties and therapeutic values

et al. 2021

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Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease-associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, and efficient treatment alternatives. Natural compounds can contribute vastly to this field. Over recent years, studies have demonstrated the remarkable protective actions of dioscin against a variety of human malignancies, metabolic

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Antioxidant and anti-inflammatory properties of taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds

Cited by 74 publications

References 24 publications

Evaluation of anti-inflammatory activity and standardisation of hydro-methanol extract of underground tuber ofDioscorea alata

Evaluation of anti-inflammatory activity and standardisation of hydro-methanol extract of underground tuber ofDioscorea alata

Antioxidant capacity of Typha angustifolia extracts and two active flavonoids

Dioscin: A review on pharmacological properties and therapeutic values

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