Antioxidant and anti-aging potential of Juniper berry ( Juniperus communis L.) essential oil in Caenorhabditis elegans model system

Pandey, Swapnil; Tiwari, Sudeep; Niranjan, Abhishek; Chand, Jai; Lehri, Alok; Chauhan, Puneet Singh

doi:10.1016/j.indcrop.2018.04.066

Cited by 44 publications

(33 citation statements)

References 56 publications

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“…In this study, the results showed that no statistically significant differences were found between the control and orange extract treatment on fecundity, which meant orange extracts did not change the reproductive capacity while extending the lifespan of C. elegans. A series of physiological functions, including the locomotor capacity, age pigment, and body length, have a connection with the lifespan [28,29]. We observed that worms supplemented with orange extracts showed more youthful and energetic mobility than control worms at different stages of the life process.…”

Section: Discussionmentioning

confidence: 77%

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Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

et al. 2020

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Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study, the Caenorhabditis elegans (C. elegans) model was used to evaluate the effects of orange extracts on lifespan and stress resistance. The results indicated that orange extracts dose-dependently increased the mean lifespan of C. elegans by 10.5%, 18.0%, and 26.2% at the concentrations of 100, 200, and 400 mg/mL, respectively. Meanwhile, orange extracts promoted the healthspan by improving motility, and decreasing the accumulation of age pigment and intracellular reactive oxygen species (ROS) levels without damaging fertility. The survival rates of orange extract-fed worms were obviously higher than those of untreated worms against thermal and ultraviolet-B (UV-B) stress. Moreover, the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly enhanced while malondialdehyde (MDA) contents were diminished. Further investigation revealed that worms supplemented with orange extracts resulted in upregulated levels of genes, including daf-16, sod-3, gst-4, sek-1, and skn-1, and the downregulation of age-1 expression. These findings revealed that orange extracts have potential anti-aging effects through extending the lifespan, enhancing stress resistance, and promoting the healthspan.

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Section: Discussionmentioning

confidence: 77%

“…The levels of ROS in C. elegans were quantified via a specific fluorescent molecular probe (DCFH-DA) according to a previous report [29,43]. Prior to the experiment, nematodes were either treated with orange extract for 5 days or left untreated as the control group as described above.…”

Section: Intracellular Ros Levelsmentioning

confidence: 99%

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

et al. 2020

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“…Several other plant extracts, including Juniperus communis L., Hypericum origanifolium Willd. are widely documented as effective anti-aging agents because of their high flavonoid and high polyphenol contents [23,24]. The flavonoids contained in plants possess potent antioxidant properties and strong UV absorption, and are widely used in skin protection [1,25].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro

She

Yuan

Zhang

et al. 2019

ARCH BIOL SCI BELGRA

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Rubus chingii Hu. is an important traditional Chinese medicine with a beneficial effect on the kidney. Traditional Chinese medicine theory believes that supporting the kidney has a key role in anti-aging. To the best of our knowledge, the anti-photoaging activity of Rubus chingii Hu. has not been investigated. We investigated the anti-photoaging effects and the underlying mechanism of the ethyl acetate fraction of Rubus chingii Hu. fruit ethanol extract (E-EA) in UVB-induced human fibroblasts (HFF-1). Our results show that E-EA (10-40 μg/mL) displayed preventive and therapeutic effects on UVB-induced cytotoxicity in HFF-1 cells. E-EA also presented significant anti-photoaging properties in UVB-induced HFF-1 cells by decreasing the levels of reactive oxygen species (ROS), inhibiting matrix metallopeptidase 1 (MMP-1) production and promoting type-I procollagen production via suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. These results suggested that E-EA might be a promising anti-photoaging agent to protect the skin from UVB damage, with a potential application in cosmetics.

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“…Essential oils are plant-based economically important secondary metabolites [9]. Citrus essential oils are extracted from citrus peels [10] that produce characteristic odors and have been widely applied to the food (beverage, sweets, and so on), cosmetics, and pharmaceutical industries mainly because of their fragrance and flavor [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Nematocidal Action against Caenorhabditis elegans of Essential Oil of Flesh Fingered Citron and Its Mechanism

Piao

Sun

2020

Journal of Chemistry

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Essential oils from flesh fingered citrons were obtained by mechanical pressing extraction under optimal conditions. Thirty-three components, representing 78.25% of the total oil, were identified by gas chromatography-mass spectrometry (GC-MS). In this study, we explored the toxicity of the essential oil of flesh fingered citrons and the associated regulatory mechanism using Caenorhabditis elegans as a model organism. The mortality experiment showed that the LD50 value is 1.48 mg/ml. Oxidative stress experiments showed that essential oils of flesh fingered citrons can reduce the antioxidation of nematodes and can shorten their lifespan. In survival rate experiments for verification, d-limonene had a nematocidal effect by destroying the waterproof protective layer on the surface of the worm. β-Pinene can interfere with the normal growth of nematodes according to behavioral experiments, and reproduction experiments showed that α-pinene has very strong nematocidal properties. γ-Terpinene also has good nematocidal activity. The results demonstrated that the essential oil of flesh fingered citron has great potential to act as a new nematicide.

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Antioxidant and anti-aging potential of Juniper berry ( Juniperus communis L.) essential oil in Caenorhabditis elegans model system

Cited by 44 publications

References 56 publications

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro

Evaluation of Nematocidal Action against Caenorhabditis elegans of Essential Oil of Flesh Fingered Citron and Its Mechanism

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