Antioxidant Activity of the Extracts from Jatropha curcas Fruit and Its Correlation with Total Phenolic Content

Saosoong, Kanda; Litthanapongsatorn, Isarawat; Ruangviriyachai, Chalerm

doi:10.13005/ojc/320237

Cited by 6 publications

(7 citation statements)

References 17 publications

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“…The leaves of J. curcas may therefore possess higher antioxidant activity than the seeds of J. curcas. This is in line with the findings of 26 , who reported that increasing antioxidant activity correlate with total phenolic content of J. curcas fruits.…”

Section: Resultssupporting

confidence: 93%

A Comparative Study on Antioxidant and Cytotoxic Potentials of Methanol Extract of Jatropha curcas Seeds and Leaves

Sulaimon

Ola-Mudathir

Abdullahi

et al. 2021

J. Drug Delivery Ther.

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Many medicinal plants have been reported to exhibit protective effects against many physiological diseases as a result of their phytochemical components which are effective antioxidants. This study was aimed at comparing the phenolic and flavonoids contents, antioxidant and cytotoxic activities of methanol extract of Jatropha curcas seeds and leaves. The cytotoxicity level of J. curcas was assessed using the brine shrimp lethality test (BSLT). The antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power (FRAP), nitric oxide scavenging activities, 2, 2’-azino-bis-(3 ethyl benzothiazoline-6-sulphonic acid (ABTS) + scavenging activities and total antioxidant capacity. The total flavonoids and total phenols content (TPC) were carried out using aluminum chloride and Folin-Ciocalteu assay respectively. The results showed that J. curcas leaves have significant higher phenolic and flavonoids contents than the seeds. The total antioxidant capacity and FRAP were also significantly higher in the leaves than the seeds of J. curcas. Furthermore, the DPPH, ABTS and Nitric oxide scavenging activities were significantly higher in the leaves than the seeds. The J. curcas leaves have a higher LD50 than the seeds. In conclusion, this study suggests the antioxidant potency as well as the safety of the crude methanol extract of the leaves of J. curcas over the seeds. Keywords: Jatropha curcas, antioxidant, cytotoxicity, flavonoids, brine shrimp lethality test, total phenolic compounds

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Section: Resultssupporting

confidence: 93%

A Comparative Study on Antioxidant and Cytotoxic Potentials of Methanol Extract of Jatropha curcas Seeds and Leaves

Sulaimon

Ola-Mudathir

Abdullahi

et al. 2021

J. Drug Delivery Ther.

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“…For instance, investigation of the methanolic extracts of J. gossypiifolia revealed the leaves to have higher total phenolic content (65.66 mg GAE/g) compared to the stem portion (33.332 mg GAE/g) [ 21 ]. Additionally, the total phenolic content of crude extract J. curcas fruit was found to possess TPC 7.04 ± 0.10 mg GAE/g of extract and 0.22–18.61 mg GAE/g of extract for its fraction [ 22 ]. The polyphenolic contents of the ethanol, methanol and aqueous extracts of the stem bark of J. curcas were also assessed by Igbinosa, et al [ 23 ], whereby the total phenol and total flavonoid were obtained in amounts of 10.92–28.87 mg tannic acid/g extract and 6.28–11.18 mg quercetin/g extract, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, in the study of Saosoong, Litthanapongsatorn and Ruangviriyachai [ 22 ], the antioxidant activity of the crude extract of J. curcas fruit was found to be 270.98 ± 0.59 μmol Fe/g of extract using the phenanthroline method, while the extract gave an IC 50 of 14.09 ± 0.05 mg/mL with the DPPH method. In particular, the methanolic fraction showed the highest antioxidant activity with an IC 50 of 0.04 ± 0.02 mg/mL with the DPPH method and an antioxidant activity of 207.53 ± 2.58 μmol Fe/g of extract with the phenanthroline method.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods

et al. 2021

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Jatropha L. species, in particular, J. curcas and J. gossypiifolia, are well known medicinal plants used for treating various diseases. In the present study, leaf and stem bark extracts of J. curcas and J. gossypiifolia obtained by maceration or homogenizer assisted extraction, were investigated for their phytochemical contents and biological potential as antioxidants, enzyme inhibitors and neuromodulators. In this regard, the gene expression of tumor necrosis factor α (TNFα) and brain-derived neurotrophic factor (BDNF) was investigated in hypothalamic HypoE22 cells. Finally, a bioinformatics analysis was carried out with the aim to unravel the putative mechanisms consistent with both metabolomic fingerprints and pharmacological effects. The leaf extracts of J. curcas showed higher total phenolic content (TPC) and total flavonoid content (TFC) than the stem bark extracts (range: 5.79–48.95 mg GAE/g and 1.64–13.99 mg RE/g, respectively), while J. gossypiifolia possessed TPC and TFC in the range of 42.62–62.83 mg GAE/g and 6.97–17.63 mg RE/g, respectively. HPLC-MS/MS analysis revealed that the leaf extracts of both species obtained by homogenizer assisted extraction are richer in phytochemical compounds compared to the stem bark extracts obtained by the same extraction method. In vitro antioxidant potentials were also demonstrated in different assays (DPPH: 6.89–193.93 mg TE/g, ABTS: 20.20–255.39 mg TE/g, CUPRAC: 21.07–333.30 mg TE/g, FRAP: 14.02–168.93 mg TE/g, metal chelating activity: 3.21–17.51 mg EDTAE/g and phosphomolybdenum assay: 1.76–3.55 mmol TE/g). In particular, the leaf extract of J. curcas and the stem bark extract of J. gossypiifolia, both obtained by homogenizer assisted extraction, showed the most potent antioxidant capacity in terms of free radical scavenging and reducing activity, which could be related to their higher TPC and TFC. Furthermore, anti-neurodegenerative (acetylcholinesterase inhibition:1.12–2.36 mg GALAE/g; butyrylcholinetserase inhibition: 0.50–3.68 mg GALAE/g), anti-hyperpigmentation (tyrosinase inhibition: 38.14–57.59 mg KAE/g) and antidiabetic (amylase inhibition: 0.28–0.62 mmol ACAE/g; glucosidase inhibition: 0.65–0.81 mmol ACAE/g) properties were displayed differentially by the different extracts. Additionally, the extracts were effective in reducing the gene expression of both TNFα and BDNF, which could be partially mediated by phenolic compounds such as naringenin, apigenin and quercetin. Indeed, the scientific data obtained from the present study complement the several other reports highlighting the pharmacological potentials of these two species, thus supporting their uses as therapeutically active plants.

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“…These results agree with Kavallieratos et al (2023), who reported that in grains treated with J. curcas L. oil (Euphorbiaceae), there was a lower emergence of S. oryzae and Ephestia küehniella Zeller (Lepidoptera: Pyralidae) compared with untreated grains. The high concentration of phenol ester in the seeds may explain the superior biocidal activity of J. curcas oil extracts (Saosoong et al, 2016). Application of the extracts directly was more efficient since extract molecules are absorbed by insects' integuments, affecting their central nervous system and leading to their death (Ubulom et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of organic extracts of Nicotiana tabacum (Solanaceae) leaf and Jatropha curcas (Euphorbiaceae) seed against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) under laboratory conditions

Tsegab,

Emana

2023

Afr. J. Biotechnol.

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The maize weevil is a pest of stored maize controlled with synthetic insecticides. The widespread use of these insecticides, however, is harmful to the environment and human health. In this study, solvent extracts (SEs) and powder treatments (PTs) of Nicotiana tabacum leaves and Jatropha curcas seeds were tested for their efficacy against Sitophilus zeamais Motschulsky. The experiment was designed in a completely randomized design with three replications. For extraction, ethyl acetate and dichloromethane were used. Extract concentrations of 25, 50, 75 and 100% were evaluated at dosages of 4, 8, and 12 ml. PT of botanicals was evaluated at dosages of 4, 8, and 12 g. Mortality was calculated at 1, 3, 5, 7, and 14 days after treatment. At the end of the experiment, the percentage of grain damage, weight loss, and germination percentage was calculated. Dichloromethane SEs of N. tabacum leaves and J. curcas seeds at 50, 75, and 100% levels of extract concentrations (LEC) in all doses caused 100% mortality. The J. curcas seed PTs at 12 g and its SEs of ethyl acetate and dichloromethane in 100% LEC at 12 ml experienced the least grain weight loss of 1.36, 0.79 and 0.64%, respectively. The results suggest that these plant-based products are very promising, generally available, cost-effective, nontoxic to non-target organisms, and simple to produce. Thus, dichloromethane SEs of N. tabacum leaves and J. curcas seeds at 50% LEC and above in all doses can be recommended for the management of S. zeamais.

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Antioxidant Activity of the Extracts from Jatropha curcas Fruit and Its Correlation with Total Phenolic Content

Cited by 6 publications

References 17 publications

A Comparative Study on Antioxidant and Cytotoxic Potentials of Methanol Extract of Jatropha curcas Seeds and Leaves

A Comparative Study on Antioxidant and Cytotoxic Potentials of Methanol Extract of Jatropha curcas Seeds and Leaves

Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods

Efficacy of organic extracts of Nicotiana tabacum (Solanaceae) leaf and Jatropha curcas (Euphorbiaceae) seed against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) under laboratory conditions

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