Antioxidant Activity of Steryl Ferulate Extracts from Rye and Wheat Bran

Nyström, Laura; Mäkinen, Marjukka; Lampi, and Anna-Maija; Piironen, Vieno

doi:10.1021/jf048051t

Cited by 114 publications

(77 citation statements)

References 28 publications

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“…Presence of minor components of steryl ferulates in wheat germ oil (48 mg/100 g) observed in the study was also reported by Yongzhi and Wang (2005). Presence of ferulic acid moiety in steryl ferulates, a powerful antioxidant, whose esterified form (ferulates) is observed to be more active than the free form (ferulic acid) in liposomes (Nystrom et al 2005).…”

Section: Resultsmentioning

confidence: 99%

Studies on the nutraceuticals composition of wheat derived oils wheat bran oil and wheat germ oil

Kumar

Krishna

2013

J Food Sci Technol

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Fat-soluble nutraceuticals of cereals are known for number of disease preventive activities. Hence wheat bran oil (WBO) and wheat germ oil (WGO) were extracted from wheat bran and germ which yielded 3.35 % and 7.35 % of oil, containing polyunsaturated fatty acids (PUFA) (64 %, 61.2 %) respectively. Both oils contained tocopherols and carotenoids, which were higher in wheat germ oil (273 mg/ 100 g, 12.23 mg/100 g) than wheat bran oil (190 mg/100 g, 2.21 mg/100 g). Steryl ferulates were also present in both the oils, but their content was eight-fold higher in WBO than in WGO. Three major steryl ferulates identified by HPLC were campesteryl ferulate and sitostenyl ferulate, campestanyl ferulate and β-sitosteryl ferulate as in γ-oryzanol and another ferulate, viz., sitostanyl ferulate. A strong IC 50 value of 7.5 mg/mL and 21.6 mg/mL DPPH free radicals scavenging for wheat germ oil for wheat bran oil was observed. NMR ( 13 C and 1 H) profile explored the evidence of distribution of antioxidant molecules in the unsaponifiable matter of wheat derived oil. Since oils rich in PUFA and minor components are required for the normal physiological activities, blending such oils with other edible oils of the diet in wheat growing countries like India may be useful to provide health benefits.

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Section: Resultsmentioning

confidence: 99%

Studies on the nutraceuticals composition of wheat derived oils wheat bran oil and wheat germ oil

Kumar

Krishna

2013

J Food Sci Technol

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“…CD contents of all oils increased slowly in the beginning of storage and the increase became faster thereafter. Moreover, the rate of formation of conjugated dienes and polymers reach an equilibrium, leading nonsignificant change in K232 (Nystrom et al, 2005). So, there was no significantly different between SBO and oil blends before 4th day; while, K232 values in SBO increased significantly.…”

Section: Oxidative Stabilitymentioning

confidence: 88%

Blending of Soybean Oil with Selected Vegetable Oils: Impact on Oxidative Stability and Radical Scavenging Activity

Ma²,

Qi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Therefore, it seems reasonable to assume that γ-ORZ components could also be used for pharmaceutical purposes. Antioxidant activity of steryl ferulates (γ-ORZ) has been shown to be similar to that of non-esterified FA, indicating that the FA moiety is responsible for the antioxidant properties (20). The aim of this study was to investigate the structure-activity relationships of FA and sterol moieties of phytosteryl ferulates in relation to antioxidant and NF-κB activities in a cell-free system and living cultured cells.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Free Radical–Scavenging, and NF-κB–Inhibitory Activities of Phytosteryl Ferulates: Structure–Activity Studies

et al. 2009

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Abstract. Some of the pharmacological properties of phytosteryl ferulates may be linked to their antioxidant potential. In this study, 2,2-diphenyl-1-picrylhydrazyl (DPPH), electron spin resonance (ESR), and thiobarbituric acid-reactive substances (TBARS) assays demonstrated that phytosteryl ferulates such as cycloartenyl ferulate (CAF), 24-methylenecycloartanyl ferulate (24-mCAF), and β-sitosteryl ferulate (β-SF) and ferulic acid (FA) each exerted strong free radical scavenging and antioxidation of lipid membrane, which were comparable to α-tocopherol. However, the sterol moiety alone, such as cycloartenol (CA), had neither activity. Since, the reactive oxygen species (ROS) production in the cell complex defense mechanism cannot be ruled out with the cell free system, we measured ROS production in NIH 3T3 fibroblast cells induced by H 2 O 2 . CAF and ethyl ferulate (eFA) greatly decreased the ROS level in this system. CA also significantly inhibited the ROS level, suggesting that CA could inhibit ROS production in living cells. Besides these, CAF, 24-mCAF, β-SF, as well as eFA and CA, all these chemicals significantly inhibited the NF-κB activity as analyzed by measuring translocation of NF-κB p65 in LPS-stimulated RAW 264.7 macrophages. These observations revealed that phytosteryl ferulates are responsible for the antioxidant and anti-inflammatory activity via ROS scavenging and inhibition of ROS production.

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Antioxidant Activity of Steryl Ferulate Extracts from Rye and Wheat Bran

Cited by 114 publications

References 28 publications

Studies on the nutraceuticals composition of wheat derived oils wheat bran oil and wheat germ oil

Studies on the nutraceuticals composition of wheat derived oils wheat bran oil and wheat germ oil

Blending of Soybean Oil with Selected Vegetable Oils: Impact on Oxidative Stability and Radical Scavenging Activity

Antioxidant, Free Radical–Scavenging, and NF-κB–Inhibitory Activities of Phytosteryl Ferulates: Structure–Activity Studies

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