Antioxidant Activity of Silica-Based Bioactive Glasses

Abstract

Bioactive glasses are the materials of choice in the field of bone regeneration. Antioxidant properties of interest to limit inflammation and foreign body reactions have been conferred to bioactive glasses by the addition of appropriate ions (such as Ce or Sr). On the other hand, the antioxidant activity of bioactive glasses without specific ion/molecular doping has been occasionally cited in the literature but never investigated in depth. In the present study, three silica-based bioactive glasses have been developed and characterized for their surface properties (wettability, zeta potential, chemical composition, and reactivity) and radical scavenging activity in the presence/absence of cells. For the first time, the antioxidant activity of simple silica-based (SiO 2 –CaO–Na 2 O) bioactive glasses has been demonstrated.

Surface Properties and Antioxidant Activity of Silicate and Borosilicate Bioactive Glasses

“…Considering these results, the mechanism beyond the radical scavenging ability of bioactive glasses, in the absence of cells, seems strictly related to their hydroxylation ability and not to the release of specific ions, as previously observed by the authors for simple silicate bioactive glasses [19] and different from specific antioxidant ions reported in the literature. [13][14][15][16][17] 3.11.…”

“…As a confirmation, in the carbon region (Figure 8a-d), the main signal is at 284.5 eV and can be associated with C─C and C─H bonds of hydrocarbon contaminants, always present on reactive surface. [18,19,50] A signal with moderate intensity appears at 286 eV, and it is ascribable to C─O bonds [18] and can be associated with carbon contaminations. The peak at 289 eV can be attributed to carbonates [18,51] and is related to surface carbonation of bioactive glasses, frequently observed, [18,51] and the C-O and carbonate peaks increase in borate glasses.…”

“…[17] Very recently, an intrinsic antioxidant activity of undoped silica-based bioactive glasses, associated with their hydroxylation degree, has been reported. [18,19] In order to extend the knowledge on the correlation between antioxidant activity and bioactive glass chemical properties, in the present work, a set of silicate and borosilicate bioactive glasses have been designed, synthetized, and characterized. Different from the preliminary previous work by the authors, [19] which was focused on simple silica-based bioactive glasses constituted by the same oxides in different proportions with consequent different reactivities, here the study is extended to various glass compositions, with include both silicate and borate glasses, with the addition of different oxides which affect the structure and the reactivity of the glasses.…”

“…[ 17 ] Very recently, an intrinsic antioxidant activity of undoped silica‐based bioactive glasses, associated with their hydroxylation degree, has been reported. [ 18,19 ]…”

Polysaccharide-based nanocomposites for biomedical applications: a critical review

“…78 Remarkably, halloysite nanotubes (HNTs) and silica nanoparticles are promising nanostructures for wound healing applications owing to their exceptional mechanical stability as well as hemostatic features. 79,80 A combination of HNTs and chitosan not only hinders bleeding but also supports faster reepithelization. 81…”