Antioxidant Activity of Resveratrol Analogs

Calil, Natalia Oliveira; Carvalho, Gustavo Senra Gonçalves de; Franco, Danielle Cristina Zimmermann; Silva, Adilson David da; Raposo, Nádia Rezende Barbosa

doi:10.2174/157018012798192928

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…Resveratrol analogs may be important compounds to provide skin whitening and some analogs tested ( A , D and E ) showed lower IC 50 values than resveratrol, the natural compound. Some of these aza-stilbenes were evaluated in recent studies for their antioxidant [21,32] and antituberculous effects [30] and together with the present results, indicate that these molecules may have pharmacological utility in a near future. Studies of the ratio between the in vitro behavior of the new analogs and their in vivo activity may contribute to the development of more effective skin whitening treatments.…”

Section: Discussionsupporting

confidence: 71%

“…All compounds were characterized by 1 H- and 13 C-NMR, recorded on a BRUKER AVANCE DRX300, infrared (IR, BOMEM-FTIR MB-102) and melting point values (Table 2) which were in accord with literature data [21,40,41,42,43,44,45]. …”

Section: Methodssupporting

confidence: 56%

“…Furthermore, it showed a more stable IC 50 in the quantitative assay compared with kojic acid. The performance of analog D may be associated to its known antioxidant capacity, as demonstrated in a previous study conducted by our group [21]. The presence of a hydroxyl group at the para -position of the aromatic ring thus appears to be critical to good antioxidant activity, as well as tyrosinase inhibitors.…”

Section: Resultsmentioning

confidence: 73%

“…Resveratrol is a polyphenolic phytoalexin that belongs to the stilbenes, which have demonstrated potent antioxidant activity [20,21,22], and numerous pharmacological activities [23,24,25,26], including tyrosinase inhibitory activity. Their hydroxyl derivatives, including oxyresveratrol, also have the same activities and have shown potent inhibitory effects on tyrosinase activity [13,27].…”

Section: Introductionmentioning

confidence: 99%

“…Such compounds have shown good antitubercular and antioxidant activity [21,31,32], which encouraged us to test the potential of this class of compounds in other areas, such as depigmenting action. Thus, this paper presents a study of the in vitro inhibitory activity of six aza-stilbenes or azaresveratrols analogs on tyrosinase activity.…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity

et al. 2012

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Skin pigmentation disorders typically involve an overproduction or uneven distribution of melanin, which results in skin spots. Resveratrol can inhibit tyrosinase, the active enzyme in the synthesis of melanin, but it does not inhibit the synthesis of melanin to an extent that enables its use alone as a skin whitening agent in pharmaceutical formulations, so its use as a coadjuvant in treatment of hyperpigmentation is suggested. Six resveratrol analogs were tested for tyrosinase inhibitory activity in vitro. Among the analogs tested, compound D was the most powerful tyrosinase inhibitor (IC50 = 28.66 µg/mL), two times more active than resveratrol (IC50 = 57.05 µg/mL), followed by the analogs A, E, B, F and C, respectively. This demonstrated that the hydroxylation at C4' on the phenolic ring was the molecular modification with most importance for the observed activity.

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Section: Discussionsupporting

confidence: 71%