Antioxidant activity of fucose-containing sulfated polysaccharides obtained from Fucus evanescens by different extraction methods

Имбс, Т. И.; Скрипцова, А. В.; Zvyagintseva, T. N.

doi:10.1007/s10811-014-0293-7

Cited by 91 publications

(54 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results were in accordance with previous published investigations. Fucoidans exert its antioxidant activity through scavenging ROS such as hydroxyl, peroxyl, and superoxide radicals [59,60], and stimulating the activities of cellular SOD, CAT, GSH-Px, GST, and glucose-6-phosphate dehydrogenase [61]. In addition, our study showed that FUC reduces the production of proinflammatory cytokines (Figure 1).…”

mentioning

confidence: 54%

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Aleissa

Alkahtani

Eldaim

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The current study was carried out to evaluate the ameliorative effect of fucoidan against aflatoxicosis-induced hepatorenal toxicity in streptozotocin-induced diabetic rats. Sixty-four Wister albino male rats were randomly assigned into eight groups (8 rats each) that received normal saline, fucoidan (FUC) at 100 mg/kg/day orally for 4 weeks, streptozotocin (STZ) at 50 mg/kg/i.p. single dose, STZ plus FUC, aflatoxin B 1 (AFB 1 ) at 50 μg/kg/i.p. after one month of the beginning of the experiment for 2 weeks, AFB 1 plus FUC, STZ plus AFB 1 , or STZ plus AFB 1 and FUC. Injection of rats with STZ induced hyperglycemia. Rats with STZ-induced diabetes, with or without AFB 1 intoxication, had significantly elevated activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and levels of serum urea, creatinine, cholesterol, 8-oxo-2′-deoxyguanosine, interleukin-1β, interleukin-6, and tumor necrosis factor-α. In addition, these rats exhibited increased lipid peroxidation and reduced glutathione concentration and activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes in the hepatic and renal tissues. In contrast, administration of FUC to diabetic rats, with or without AFB 1 intoxication, ameliorated the altered serum parameters, reduced oxidative stress, DNA damage, and inflammatory biomarkers, and enhanced the antioxidant defense system in the hepatic and renal tissues. These results indicated that FUC ameliorated diabetes and AFB 1 -induced hepatorenal injuries through alleviating oxidative stress, DNA damage, and inflammation.

show abstract

mentioning

confidence: 54%

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Aleissa

Alkahtani

Eldaim

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Notably, Imbs et al (2015) identified a strong positive correlation between polyphenol content in fucose-containing sulfated polysaccharides from F. evanescens and their antioxidant activity. The authors suggest that phenols play a key role in the previously described antioxidant capacity of fucoidan from F. evanescens.…”

Section: Free Radicalsmentioning

confidence: 94%

“…The pleiotropic anti-inflammatory effects of fucoidan considered here, consist of the inhibition of selectin (Barrab es et al 2005), the complement system, and enzymes that participate in tissue destruction and inflammation, such as heparanases, elastases and matrix metalloproteinases (MMP) (Thomas & Kim 2014), as well as the blockage of scavenger receptors on macrophages (Yamomoto et al 1997), the deceleration of leukocyte migration into the subendothelial space of vessels (Cumashi et al 2007), normalization of the balance of pro-and anti-inflammatory mediators , and the modification of the oxidation-reduction potential of neutrophils (Imbs et al 2015;Tariq et al 2015).…”

Section: Therapeutic Targets For Fucoidan In Atherosclerosismentioning

confidence: 99%

Prospects for the therapeutic application of sulfated polysaccharides of brown algae in diseases of the cardiovascular system: review

Ts¹,

Беседнова²

2016

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Fucoidans are water-soluble, highly sulfated, branched homo-and hetero-polysaccharides derived from the fibrillar cell walls and intercellular spaces of brown seaweeds of the class Phaeophyceae. Fucoidans possess mimetic properties of the natural ligands of protein receptors and regulate functions of biological systems via key signaling molecules. Objectives: The aim of this review was to collect and combine all available scientific literature about the potential use of the fucoidans for diseases of cardiovascular system. Materials and methods: The review has been compiled using references from major databases such as Web of Science, PubMed, Scopus, Elsevier, Springer and Google Scholar (up to September 2015). After obtaining all reports from database (a total number is about 580), the papers were carefully analyzed in order to find data related to the topic of this review (129 references). Results: An exhaustive survey of literature revealed that fucoidans possess a broad spectrum of biological activity, including anti-coagulant, hypolipidemic, anti-thrombotic, anti-inflammatory, immunomodulatory, anti-tumor, anti-adhesive and anti-hypertensive properties. Numerous investigations of fucoidans in diseases of the cardiovascular system mainly focus on pleiotropic anti-inflammatory effects. Fucoidans also possess pro-angiogenic and pro-vasculogenic properties. Conclusion: A great number of investigations in the past years have demonstrated that fucoidans has great potential for in-depth investigation of their effects on cardiovascular system. Through this review, the authors hope to attract the attention of researchers to use fucoidan as mimetic of natural ligand receptor protein with the view of developing new formulations with an improved therapeutic value. ARTICLE HISTORY

show abstract

“…Brown alga F. evanescens was collected in Iturup Island, Sea of Okhotsk, in August 2015. Fucoidans from F. evanescens and Undaria pinnatifida were isolated by the previously reported methods [17,18].…”

Section: Methodsmentioning

confidence: 99%

Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases

et al. 2017

View full text Add to dashboard Cite

Fucoidan hydrolase inhibitors were discovered for the first time. Metabolites in the aqueous EtOH extract of Fucus evanescens inhibited specifically the activity of enzymes involved in catabolism of brown-alga polysaccharides, i.e., fucoidanases (recombinant FFA from the marine bacterium Formosa algae KMM 3553T and PPF from the marine mollusk Patinopecten yessoensis) and glycosidases (recombinant D-L-fucosidase FucFa from F. algae and E-D-glucosidase G-II from the marine mollusk Littorina sitkana). The purified fucophlorethol fraction isolated from this extract inhibited recombinant fucoidanase FFA in the concentration range 10-50 Pg/mL.Enzyme-catalyzed biochemical reactions are fundamental to in vivo metabolic processes. Enzyme inhibitors are very significant in pharmacology and toxicology and are used to study enzyme mechanisms of action and establish the active-site structures because of their high specificity.Carbohydrase inhibitors from natural sources have stimulated unwavering interest. Enzyme inhibitors in nature are known to act often as interspecies relationship regulators. For example, amylase inhibitors from grain sprouts are toxic for insects and mammals. Furthermore, amylase inhibitors were detected among so-called pathogen-responsive proteins (PR-proteins) involved in the plant protective mechanism. Amylases and glycosidases are the most studied natural inhibitors. Their effects on plant-insect relationships or forage animals are being actively studied [1,2].Brown algae, like terrestrial plants, protect themselves from predation by marine invertebrates or microorganisms by synthesizing alginate lyases, laminarinases, and fucoidanases. Reports of carbohydrase inhibitors from marine sources are very sparse [3,4], as for fucoidanase producers [5,6].We discovered several sources that biosynthesize active fucoidan hydrolases [7,8]. The role of these enzymes and; correspondingly, their inhibitors, is difficult to overestimate because all brown algae synthesize fucoidans. The total mass of these polysaccharides in nature is enormous and should be utilized in some manner.The goal of the present research was to seek fucoidan hydrolase inhibitors among metabolites of brown algae inhabiting the seas of the Russian Far East.Enzymes involved in brown alga polysaccharide catabolism were used to discover inhibitors. These were highly purified fucoidanases (recombinant FFA from the marine bacterium Formosa algae KMM 3553T [7] and PPF from the marine mollusk Patinopecten yessoensis [6]) and glycosidases (E-D-glucosidase G-II from the marine mollusk Littorina sitkana [9] and recombinant D-L-fucosidase FucFa from F. algae). Recombinant D-L-fucosidase FucFa was prepared especially for this research because it is involved in fucoidan catabolism. E-D-Glucosidase G-II, which catalyzes hydrolysis of laminarioligosaccharides and laminaran, was used to demonstrate the specificity of the discovered fucoidan hydrolase inhibitors. Fucoidan from Fucus evanescens was used as the substrate for the fucoidanases; p-Np-D-L-fuco-and ...

show abstract

Antioxidant activity of fucose-containing sulfated polysaccharides obtained from Fucus evanescens by different extraction methods

Cited by 91 publications

References 45 publications

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Prospects for the therapeutic application of sulfated polysaccharides of brown algae in diseases of the cardiovascular system: review

Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases

Contact Info

Product

Resources

About

Antioxidant activity of fucose-containing sulfated polysaccharides obtained from Fucus evanescens by different extraction methods

Cited by 91 publications

References 45 publications

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1

Prospects for the therapeutic application of sulfated polysaccharides of brown algae in diseases of the cardiovascular system: review

Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases

Contact Info

Product

Resources

About

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁