Antioxidant activity of flavonoids from Solanum melongena

Sudheesh, Siji; Sandhya, Chandran; Koshy, Asha Sarah; Vijayalakshmi, N.

doi:10.1002/(sici)1099-1573(199908/09)13:5<393::aid-ptr474>3.0.co;2-8

Cited by 95 publications

(66 citation statements)

References 14 publications

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“…both in humans and in animals (Cody et al, 1986;1988;Sudheesh et al, 1999). Chacon et al (2002) observed an absence of genotoxic effects of a standardized extract of the medicinal plant Solanum melongena, rich in flavonoids, on peripheral blood and bone marrow cells of Wistar rats and Ferreira et al (2003) related that the same extract presented protective effects against chromosomal aberrations induced by doxorubicin in Wistar rat cells.…”

Section: Resultsmentioning

confidence: 69%

Evaluation of the genotoxic potential of the Hypericum brasiliense (Guttiferae) extract in mammalian cell system in vivo

et al. 2005

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Plants of the genus Hypericum, long used in folk medicine, contain active compounds which present, anti-septic, diuretic, digestive, expectorant, vermifugal, anti-depressive and other properties. The possible clastogenic effect of a H. brasiliense extract was tested in vivo on the bone marrow cells of Wistar rats. The extract was administered by gavage at doses of 50, 150 and 300 mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment for micronucleus (MN) and chromosome preparations. H. brasiliense extract did not induce statistically significant increases in the average numbers of MN or chromosome aberrations in the test systems employed.

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Section: Resultsmentioning

confidence: 69%

Evaluation of the genotoxic potential of the Hypericum brasiliense (Guttiferae) extract in mammalian cell system in vivo

et al. 2005

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“…These results are in agreement with those of Paczkowski and Wojciechowski (22), who found steroidal saponins in S. melongena samples. Although flavonoids were not found in our analysis of the infusion, these compounds have also been reported to have some effects on cholesterol metabolism (23,24). Flavonoids have been suggested to be the hypocholesterolemic agents of several vegetables.…”

Section: Discussionmentioning

confidence: 99%

“…The concentrations of hepatic and fecal bile acids and fecal neutral sterols were also increased, indicating a higher rate of cholesterol degradation. Flavonoids isolated from S. melongena also showed a potent antioxidant activity (24)(25)(26). Concentrations of malondialdehyde, hydroperoxides and conjugated dienes were significantly reduced.…”

Section: Discussionmentioning

confidence: 99%

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects

Guimarães

Galvão

Batista

et al. 2000

Braz J Med Biol Res

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Eggplant (Solanum melongena) is consumed extensively in Brazil. It has been believed that infusion of a powdered preparation of the fruit may reduce serum cholesterol. However, there are few documented reports on its effects on cholesterol metabolism and its possible hypocholesterolemic effect has not been proved by well-controlled studies. The aim of the present study was to observe the effects of S. melongena on the serum cholesterol and triglycerides of 38 hypercholesterolemic human volunteers ingesting S. melongena infusion for five weeks. Thirty-eight hypercholesterolemic subjects receiving either S. melongena infusion (N = 19) or placebo (N = 19) participated in two clinical experiments in which the effect of S. melongena infusion was studied with (N = 16) or without (N = 38) dietary orientation. Total cholesterol and its fractions, triglycerides, and apolipoproteins A and B were measured in blood at the beginning of the experiment and three and five weeks thereafter. No differences were observed compared to control. Intraindividual analysis showed that S. melongena infusion significantly reduced the blood levels of total and LDL cholesterol and of apolipoprotein B. After dietary orientation, no intra-or intergroup differences were seen for any of the parameters analyzed. The results suggest that S. melongena infusion had a modest and transitory effect, which was not different from that obtained with standard orientation for dyslipidemia patients (diet and physical activities).

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“…Trabalhando com colesterol marcado com carbono radiotivo, Kritchevsky et al (1975) (Sudheesh et al, 1999). Silva et al (1999) testaram o efeito do chá de berinjela (S. melongena) nos níveis séricos e hepáticos de colesterol e triglicérides em ratos adultos.…”

Section: Berinjela (Solanum Melongena): Alimento Hipolipemianteunclassified

Berinjela (Solanum melongena L.): mito ou realidade no combate as dislipidemias?

Gonçalves¹,

Diniz²,

Borba³

et al. 2006

Rev. bras. farmacogn.

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RESUMO:A dislipidemia é considerada um dos fatores de risco mais importantes para o desenvolvimento da doença arterial coronariana. Como resultado, tratamentos efetivos com fármacos foram desenvolvidos para combatê-la, porém, apresentam alto custo e efeitos colaterais. Considerando este fato, pacientes têm recorrido a tratamentos utilizando alimentos conhecidos científi ca e popularmente por possuírem efeito hipolipemiante. Várias pesquisas vêm sendo realizadas com esses alimentos como a berinjela no sentido de investigarem seus possíveis efeitos na redução dos lipídios sangüíneos. A berinjela (Solanum melongena L.) tem sido alvo desses estudos devido a sua utilização popular para dietas de emagrecimento, por aumentar a eliminação de gorduras e combater o excesso de colesterol. Este trabalho teve como objetivo fazer uma revisão da literatura científi ca sobre a espécie Solanum melongena (berinjela) da família Solanaceae, associado a redução de gorduras no organismo. Para este fi m foram consultados vinte e cinco referências.Unitermos: Solanum melongena, berinjela, dislipidemia, colesterol, revisão.ABSTRACT: "Eggplant (Solanum melongena L.) -myth or reality in the fi ght against the dislipidemy?". High cholesterol is considered one of the most important factors for the coronary arterial disease development. As a result, effective treatments with medicine were developed to fi ght it; even so, they present high cost and collateral effects. Considering this fact, patients have required treatments using popular and scientifi c wellknown food whose effect is to decrease the fat rate. Several researches are being carried out with eggplant with the objective of investigating their possible effects in the reduction of the blood fat. The species Solanum melongena has been the target of several studies due to its popular use in weight-loss diets, as it increases the elimination of fat and fi ghts the exceeding cholesterol. This work aims at showing a literature review about the species Solanum melongena, of the family Solanaceae, associated with the reduction of fats by the organism. For this purpose twenty-fi ve references were consulted.Keywords: Solanum melongena, eggplant, dislipidemy, cholesterol, review. INTRODUÇÃOSegundo a Organização Mundial de Saúde, as doenças cardiovasculares apresentam uma incidência elevada em todo o mundo e têm como fator de risco as dislipidemias que, isoladamente ou associadas a outros fatores como tabagismo, obesidade, diabetes, etc. podem com o avançar da idade, provocar o aparecimento dessas patologias (III Diretrizes sobre dislipidemias e ateriosclerose, 2001). Embora muitos progressos tenham contribuído para melhor entendimento do seu mecanismo, ainda permanece muito a ser desvendado e eventos por ela desencadeados como infarto do miocárdio, por exemplo, continuam sendo causa de óbitos nas sociedades urbanas.Estudos de intervenção têm mostrado que o risco para a doença arterial coronariana pode ser reduzido, quando os níveis séricos de colesterol são controlados pela dieta ou tratament...

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Antioxidant activity of flavonoids from Solanum melongena

Cited by 95 publications

References 14 publications

Evaluation of the genotoxic potential of the Hypericum brasiliense (Guttiferae) extract in mammalian cell system in vivo

Evaluation of the genotoxic potential of the Hypericum brasiliense (Guttiferae) extract in mammalian cell system in vivo

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects

Berinjela (Solanum melongena L.): mito ou realidade no combate as dislipidemias?

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