Antioxidant activity of extracts from in vitro cultures of Salvia officinalis L.

Grzegorczyk, Izabela; Matkowski, Adam; Wysokińska, Halina

doi:10.1016/j.foodchem.2006.12.003

Cited by 187 publications

(119 citation statements)

References 13 publications

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“…Recently, medicinal plants have gained a remarkable attention, especially those rich in flavonoids and phenolic acids contents, which are known with their antioxidant properties (Grzegorczyk et al 2007 ROS and enhancing host antioxidant defense systems (Subapriya et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl ₄ -induced changes in the genetic materials in male rats

Elkhateeb¹,

Latif²,

Marzouk³

et al. 2016

Pharmaceutical Biology

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Context: Dobera glabra (Forssk.) Poir (Salvadoraceae) is a highly valued tree with diverse importance as special mineral sourced feed and a folkloric tool for forecasting droughts. However, there are no reports on its phytochemical and biological investigations. Objective: Phytochemical investigation of D. glabra leaves and its protective potential against CCl 4 inducing changes in the genetic materials. Materials and methods: D. glabra extract, DGE (70% MeOH/H 2 O), was applied to polyamide column chromatography, eluting with MeOH/H 2 O of decreasing polarities, followed by preparative chromatographic tools, yielded seven compounds. Three DGE doses (50, 100 and 200 mg/kg bw/d) were administrated for 8 weeks intragastrically to male albino rats prior treated with CCl 4 (0.5 mL/kg/bw). The reactive oxygen species (ROS) levels, expression changes of glutamate transporters (GLAST, GLT-1 and SNAT3) mRNA, DNA fragmentation and glutathione peroxidase (GPx) activity were investigated in the liver tissues of these rats.and kaempferol were identified. DGE (200 mg/kg bw) þ CCl 4 exhibited the most significant reduction in ROS levels and DNA fragmentation with 251.3% and141% compared to 523.1% and 273.2% for CCl 4 , respectively. Additionally, it increased significantly the mRNA expression of GLAST, GLT-1 and SNAT3 to 2.16-, 1.72-and 2.09-fold, respectively. Also, GPx activity was increased to 4.8 U/mg protein/min compared to CCl 4 (1.8 U/mg protein/min). Discussion and conclusion: Flavonoid constituents, antioxidant effect and genotoxic protection activity of D. glabra were first reported. DGE may be valuable in the treatment and hindrance of hepatic oxidative stress and genotoxicity.ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl ₄ -induced changes in the genetic materials in male rats

Elkhateeb¹,

Latif²,

Marzouk³

et al. 2016

Pharmaceutical Biology

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“…Callus has been reported to exhibit biological activities which are often similar to the original plant (Rasool et al 2011). Higher antioxidant potential of acetone extract of in vitro Salvia officinalis shoots, compared to extracts of naturally grown plants, was found using a linoleic acid oxidation prevention assay (Grzegorczyk et al 2007). Thus in vitro culture technique seems to an alternative to whole plants for the production of useful secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antioxidant activity of methanol extracts ofCrocus sativusL.c.v. Kashmirianus

Parray

Kamili

Hamid

et al. 2014

Frontiers in Life Science

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In this study, we investigated the antibacterial and antioxidant activities of Crocus sativus L. Kashmirianus c.v. extracts (callus and stigmas). Profuse callus was obtained on MS medium enriched with BAP (20 µM) + NAA(15 µM) under in vitro conditions from corm slices. Four pathogenic bacterial strains (Staphylococcus aureus CD0001, Escherichia coli CD0006, Pseudomonas aeruginosa CD0023 and Shigella flexneri CD0033) were used for determining the antibacterial activity of extracts. The antioxidant activity was determined by DPPH assay, DNA protection assay, FTC method, TBA assay and lipid peroxidation assay. The methanol stigma extract of saffron was found to be more effective in inhibiting all the pathogenic strains. The stigma extract also showed significant radical scavenging or chelation capacities in four of the methods; however, callus extract exhibited maximum inhibition of peroxy-radicals in lipid peroxidation assay. The protocol for callus production is described. It was concluded that as well as the specific parts of plants displaying diverse pharmacological activities, callus produced under in vitro conditions will assist in enhancing the production of secondary metabolites, which will reduce the pressure on natural saffron.Keywords: antioxidant activity; callus; in vitro culture; MIC; methanol; saffron; stigma Abbreviations: BAP = 6-benzyl adenine purine BHT = butylated hydroxyl toluene FTC = ferric thiocyanate MIC = minimum inhibitory concentration NAA = naphthalene acetic acid TBA = thiobarbituric acid.

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“…When the generation of the active oxygen-free radical is overgrown many degenerative diseases, such as brain dysfunction, cancer, heart diseases, age-related degenerative conditions, declination of the immune system, cancer, coronary arteriosclerosis, ageing processes, carcinogenesis, gastric ulcer and DNA damage arise [5][6][7][8][9] . Thus, it is essential to develop and utilize effective natural antioxidants so that they can protect the human body from free radicals and retard the progress of many chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Pedalium murex Linn (Pedaliaceae) fruits: a comparative antioxidant activity of its different fractions

Patel

Kumar

Prasad

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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Antioxidant activity of extracts from in vitro cultures of Salvia officinalis L.

Cited by 187 publications

References 13 publications

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl ₄ -induced changes in the genetic materials in male rats

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl ₄ -induced changes in the genetic materials in male rats

Antibacterial and antioxidant activity of methanol extracts ofCrocus sativusL.c.v. Kashmirianus

Pedalium murex Linn (Pedaliaceae) fruits: a comparative antioxidant activity of its different fractions

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Antioxidant activity of extracts from in vitro cultures of Salvia officinalis L.

Cited by 187 publications

References 13 publications

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl 4 -induced changes in the genetic materials in male rats

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl 4 -induced changes in the genetic materials in male rats

Antibacterial and antioxidant activity of methanol extracts ofCrocus sativusL.c.v. Kashmirianus

Pedalium murex Linn (Pedaliaceae) fruits: a comparative antioxidant activity of its different fractions

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Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl ₄ -induced changes in the genetic materials in male rats

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl ₄ -induced changes in the genetic materials in male rats