Antibacterial and antioxidant activity of methanol extracts of<i>Crocus sativus</i>L.<i>c.v</i>. Kashmirianus

Parray, Javid A.; Kamili, Azra N.; Hamid, Rehana; Reshi, Zafar A.; Qadri, Raies A.

doi:10.1080/21553769.2014.951774

Cited by 36 publications

(32 citation statements)

References 27 publications

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“…There is no report on the phytochemistry or any other scientific study on C. mathewii. C. sativus, a sister species has been investigated for various bioactivities like antioxidant [9,10] , antityrosinase [11] , free radical scavenging and ferric reducing [12] , antibacterial [13] and inhibitory activity on amyloid-β aggregation [9] .…”

Section: Research Papermentioning

confidence: 99%

Green Synthesis and Characterization of Silver Nanoparticles from Crocus Mathewii; A Disremembered Turkish Flowering Plant

Yildiztekin¹,

Nadeem²,

Yildiztekin³

et al. 2017

pharmaceutical-sciences

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Mahmut, et al.: Characterization of Silver Nanoparticles from Crocus mathewiiThis study reports the first ever chemical study on Crocus mathewii, a Turkish endemic and forgotten flowering plant. Silver nanoparticles were green synthesized from one mmol×l -1 silver nitrate extract of C. mathewii. The water-suspended silver nanoparticles showed a peak at 423 nm in UV/Vis spectrophotometer that suggested smaller particle size due to its less surface plasmon resonance. Transmission electron microscopy analysis also proved excellent polydispersity of quasi-spherical particle size distribution with average particles of 7.5 nm (2.5-25 nm). The presence of silver in the nanoparticles was analyzed by X-ray diffraction, while Fourier transform infrared spectroscopy analysis showed the presence of various -OH and -NH containing organics. The results proved that the crude extract of C. mathewii can be used for green synthesis of silver nanoparticles in future for medicinal uses.

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Section: Research Papermentioning

confidence: 99%

Green Synthesis and Characterization of Silver Nanoparticles from Crocus Mathewii; A Disremembered Turkish Flowering Plant

Yildiztekin¹,

Nadeem²,

Yildiztekin³

et al. 2017

pharmaceutical-sciences

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“…Karimi et al (2010) studied free radical scavenging and ferric reducing activities of the C. sativus stigma and found notable activities, i.e., 68.2% and 78.9%, at a concentration of 300 mg/mL. This plant has also been reported to have antibacterial (Parray et al 2014) and inhibitory activity on amyloid-b-aggregation (Papandreou et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, anticholinesterase and tyrosinase inhibition activities, and fatty acids of Crocus mathewii – A forgotten endemic angiosperm of Turkey

Yildiztekin

Nadeem

Erol

et al. 2016

Pharmaceutical Biology

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Context We report the first ever chemical/biochemical study on Crocus mathewii Kerndorff (Iridaceae) -a Turkish endemic angiosperm. This plant has never been explored for its phytochemistry and bioactivities. Objective This study explores C. mathewii corm and aerial parts for the chemical and biological properties of hexane, ethyl acetate, methanol and water fractions of the extracts. Material and methods Plant material (20 g) was extracted by methanol (250 mL Â 5, 3 days each) and fractioned into hexane, ethyl acetate, methanol and water. All fractions were subjected to b-carotene-linoleic acid, DPPH Á , ABTS Á+ , CUPRAC, metal chelating and tyrosinase inhibition activities. Hexane fractions were submitted to GC-MS analysis. Results Ethyl acetate fractions showed excellent IC 50 values in DPPH Á (aerial 36.21 ± 0.76 and corm 33.87 ± 0.02 mg/L) and ABTS Á+ (aerial 33.01 ± 0.79 and bulb 27.87 ± 0.33 mg/L); higher than the IC 50 of the standard a-tocopherol (DPPH 116.25 ± 1.97; ABTS 52.64 ± 0.37 mg/L), higher than BHA in DPPH (57.31 ± 0.25 mg/L), but slightly lower in ABTS (19.86 ± 2.73 mg/L). Methanol extract of aerial parts also showed higher activity than a-tocopherol in DPPH (85.56 ± 11.51 mg/L) but slightly less (72.90 ± 3.66 mg/L) than both the standards in ABTS. Linoleic (aerial 53.9%, corm 43.9%) and palmitic (aerial 22.2%, corm 18%) were found as the major fatty acids. Discussion and conclusion Some fractions of C. mathewii showed higher antioxidant activities than the standards. There is a need to explore more about this plant. ARTICLE HISTORY

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“…The viscosity of DNA solution is sensitive to the addition of metal complexes which can bind to DNA. While classical intercalative mode causes a significant increase in viscosity of DNA solution due to separation of base pairs at intercalation sites and increase in overall DNA length, complexes those bind exclusively in DNA grooves typically causes less positive or negative or no change in DNA viscosity [74]. The relative specific viscosity was calculated using the equation (tto/t0 ) where to is the flow time for the buffer and t is the observed flow time for DNA in absence and presence of complex.…”

Section: H Viscosity Measurementsmentioning

confidence: 99%

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Tak¹

2017

IJRASET

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Novel complexes of copper (II), cobalt (II) and nickel (II) with sulphapyridine and aminothiazole were synthesized and characterized using spectral and analytical techniques. The interaction of cobalt (II) complexes with herring sperm DNA has been performed using absorption titration, viscometric measurements and cyclic voltammetry. The protective activity of metal complexes has been carried out using arose gel electrophoresis. The results indicate that cobalt (II) complex bind to DNA via electrostatic or groove binding with binding constant K b = 4.5 x 10 4 M -1. The antioxidant activity for cobalt (II) complex was also checked. Keywords: hypochromism, peak potential and binding constant. I. INTRODUCTIONThe binding of metal complexes to DNA has been extensively studied over the past decade. Many coordination compounds are able to bind DNA as structural probes[1], DNA foot printing [2], DNA cleaving agents [3][4] and as potential anticancer drugs [5][6]. It is generally believed that many anticancer, antiviral, and antiseptic agents take action through binding DNA [4,[7][8], since the interaction between small molecules and DNA can often cause DNA damage in cancer cells, blocking the division of cancer cells and resulting in cell death [9][10][11]. Many studies indicate that transition metal complexes can bind to DNA via both covalent (replacement of labile coordinating ligand by nitrogen base of DNA (i.e. adenine, Cytosine, guanine, thymine) and or non covalent interaction (intercalation, electrostatic or groove binding) [12]. Many important applications of these complexes require that they can bind via intercalative mode or groove binding [13]. Therefore interaction of complexes especially with planar aromatic heterocyclic ligands, which can insert into the base pairs of DNA duplex has attracted considerable attention [14][15][16]. is an essential element widely distributed in biological system [6,[17][18]. Numerous cobalt complexes has been studied as hydrolytic agent for DNA cleavage [19-20], antitumor, antproli-ferative[21-23], antimicrobial[24-26] and antifungal [21,27], antiviral [28,29], antioxidant [12 ,30] and ant inflammatory activity [30]. They have exhibited antitumorogenic activity by reducing the number and size of carcinogen induced colon tumors and play synergistic role on the activity of certain antitumor drugs, although the mechanism has not been completely clarified [31][32][33]. Ligands having nitrogen donors received considerable attention because of their mixed hard-soft donor character, versatile coordination behavior [34][35] and for their biological activity (i.e., toxicity against bacterial growth [36], anticancer [37] and other biochemical properties [38]). The coordination geometry and nature of donor atoms play key roles in determining the binding extent of complexes to DNA. The importance of central metal ion at the core of the structure is noteworthy [39,40]. Many DNA heterocyclic compounds such as benzothiazole and benzopyra zine derivatives have been evaluated and f...

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Antibacterial and antioxidant activity of methanol extracts ofCrocus sativusL.c.v. Kashmirianus

Cited by 36 publications

References 27 publications

Green Synthesis and Characterization of Silver Nanoparticles from Crocus Mathewii; A Disremembered Turkish Flowering Plant

Green Synthesis and Characterization of Silver Nanoparticles from Crocus Mathewii; A Disremembered Turkish Flowering Plant

Antioxidant, anticholinesterase and tyrosinase inhibition activities, and fatty acids of Crocus mathewii – A forgotten endemic angiosperm of Turkey

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

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