Antioxidant activity of costunolide and eremanthin isolated from Costus speciosus (Koen ex. Retz) Sm.

Eliza, J.; Daisy, P.; Ignacimuthu, Savarimuthu

doi:10.1016/j.cbi.2010.08.002

Cited by 98 publications

(75 citation statements)

References 41 publications

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“…GPx, a selenium containing enzyme, detoxifies H 2 O 2 to H 2 O and molecular oxygen through the oxidation of reduced glutathione. Thus, protecting the tissues against oxidative damage caused by reactive hydroxyl radicals [33]. A decrease in the activities of these enzymatic antioxidants in diabetic condition may result in a deleterious effect due to an excess availability of superoxide radicals and H 2 O 2 which in turn generates hydroxyl radicals, resulting in initiation and propagation of lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats

Anitha¹,

Rajadurai²

2014

Biomedicine & Preventive Nutrition

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Section: Discussionmentioning

confidence: 99%

Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats

Anitha¹,

Rajadurai²

2014

Biomedicine & Preventive Nutrition

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“…Three of flavonoids such as quercitin and rutin and quercitrin were known to possess very high anti-oxidant activity (Chang et al, 2012). It has also been reported that two of the constituent of Costus speciosus, Costunolide and eremanthin could significantly reduced TBARS level and increase GSH level (Elisa et al, 2010). This anti-oxidant activity could also be the possible mechanism of anti-arthritic effect of Costus speciosus.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of in-vivo antiarthritic potential of methanolic extract of Costus speciosus rhizome

Kala¹,

Ali²,

Abid³

et al. 2015

J App Pharm Sci

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Objective: To evaluate anti-arthritic potential of methanolic extract of rhizome of Costus speciosus Koen. Methods: The powdered drug was extracted with 80% methanol. The crude extract was subjected to phytochemical investigation and was evaluated for its anti-arthritic potential by freund's complete adjuvant induced arthritis model in adult wistar albino rats. Determination of different parameters like arthritic score, arthritic index, paw thickness, body weight, and pain, altered liver enzymes and biochemical estimation like, nitric oxide level and Plasma TNF-α level was done. Finally, radiological estimation and histopathology of tibio tarsal joints was performed. Statistical analysis was performed using one way ANOVA followed by Dunnet's test at different p-values. Results: Phytochemical study revealed the presence of flavonoids, phenolic compound, saponins and carbohydrates. For different parameter mentioned above, anti-arthritic activity shown by prophylactic high dose test extract (200 mg/kg) was as potent as standard drug Indomethacin (10 mg/kg). The effect of Prophylactic low dose extract (100 mg/kg) and therapeutic high dose extract (200 mg/kg) was less than that of Indomethacin (10 mg/kg). Furthermore, Therapeutic low dose extract (100 mg/kg) was not effective. Conclusions: The obtained results indicate that Costus speciosus rhizome extract possess significant anti-arthrtic potential.

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“…Saussurea costus is considered to be one of the antioxidant-rich medicinal plants. Many authors have reported that the roots of this plant possess various biological activities, including cortisol lowering effect [38], anti-infammatory [39,40], anticancer [41,42], antiviral [23], antimicrobial [43,44], antifungal [15], antioxidant [45,46], antidiabetic [47], antiulcer [20] and hepatoprotective effects [38]. Liv-52 is widely used in treatment of liver diseases of varying origins.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Costus Roots Extract against Carbon Tetrachloride (CCl4)-Induced Liver Injury in Guinea Pigs

Al-Duais¹,

Al-Awthan²

2017

JLS

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SC (Saussurea costus) (Asteraceae) is a traditionally known and potent plant which is well considered for its medicinal uses in different indigenous Indian systems of medicine. This study was undertaken to investigate the hepatoprotective effect of SC against liver injury induced by CCl 4 intoxication. Animals were divided into five groups. Group I, served as normal control. Group II received 2 mL CCl 4 /kg b.w. diluted with olive oil, at 1:1 ratio on day 11. Groups III and IV were pre-treated orally respectively with 100 and 200 mg/kg b.w. aqueous roots extract of SC for 10 days followed by subcutaneous injection of CCl 4 (2 mL/kg b.w.), once on day 11. Group V were orally given Liv-52 (100 mg/kg b.w.) once daily for 10 days followed by subcutaneous injection of CCl 4 (2 mL/kg b.w.), once on day 11. Our results show that, the activity of serum hepatic enzymes (ALT, AST, and ALP) were significantly elevated in guinea pigs treated with CCl 4 , while both the SC root extract and Liv-52 reduced significantly these enzymes activity. Also, the levels of glucose, urea and cholesterol were decreased when compared with intoxicated control. Histopathological examination of intoxicated animals showed dilation, hemorrhage, vacuolization, inflammation and necrosis indicating liver damage, while the animals received SC or Liv-52 that showed less pathological effects or normal liver when compared to animals treated with CCl 4 alone. Biochemical and histological results confirm the hepatoprotective effect of aqueous extract of SC.

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Antioxidant activity of costunolide and eremanthin isolated from Costus speciosus (Koen ex. Retz) Sm.

Cited by 98 publications

References 41 publications

Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats

Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats

Evaluation of in-vivo antiarthritic potential of methanolic extract of Costus speciosus rhizome

Hepatoprotective Effect of Costus Roots Extract against Carbon Tetrachloride (CCl4)-Induced Liver Injury in Guinea Pigs

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