Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats

Anitha, Takkallapalli; Rajadurai, M.

doi:10.1016/j.bionut.2014.08.008

Cited by 25 publications

(20 citation statements)

References 38 publications

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“…Since in our study the activity of glutathione reductase was not altered by chrysin supplementation, we presume that chrysin promotes de novo GSH synthesis rather than the restoration of GSH from GSSG. Chrysin is reported to increase the GSH level in various organs of diabetic animals [27,66], which is consistent with our report.…”

Section: Discussionsupporting

confidence: 93%

“…Chrysin (Sigma-Aldrich, St. Louis, MO, USA) suspended in water was administered once a day via intragastric tube from the day of diabetes confirmation for 28 days. Based on literature data and the fact that chrysin reveals low yet dose-dependent bioavailability, two doses of this flavone (50 mg/kg and 100 mg/kg) were chosen for this study [18,[26][27][28]. Chrysin suspensions were prepared daily, directly before administration, by suspending 50 or 100 mg of chrysin in 1 mL of water.…”

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confidence: 99%

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Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

et al. 2020

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Prolonged hyperglycemia is one of the main causes of reactive oxygen species and free radicals generation in diabetes which may affect various organs, including the eye. Oxidative damage to proteins and lipids in the eye lens could lead to cataract formation. To cope with oxidative stress, the endogenous antioxidative system may be supported by the supplementation of exogenous antioxidants. The aim of this study was to evaluate the effect of chrysin, a natural flavonoid, on oxidative stress and polyol pathway-related markers in the lenses of streptozotocin-induced type 1 male diabetic rats. Chrysin at doses of 50 and 100 mg/kg was administered by gavage for 28 days. This treatment resulted in a decrease in antioxidative enzymes activity and oxidative stress index. Moreover, chrysin administration elevated the reduced glutathione level in the lenses. A decrease in the markers linked to oxidative damage to proteins and lipids in the lenses was noted, especially after treatment with 50 mg/kg of chrysin. Neither of the chrysin doses affected glycemia-related markers in the serum or altered parameters related to the polyol pathway and advanced glycation end-products level in the lenses of diabetic rats. Upon obtaining results, it can be concluded that chrysin reveals antioxidative activity in the lenses but shows no antihyperglycemic or antiglycation properties.

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

et al. 2020

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“…Chrysin (5,7-dihydroxyflavone), a natural flavonoid widely distributed in plants, has a variety of pharmacological effects, including antiviral [3], antiinflammation [4], antioxidant [5], anticancer [6], and antibacterial effect [7]. In order to improve the biological activities of chrysin, a number of its derivatives have been prepared [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

The crystal structure of benzenaminium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate hydrate, C₂₁H₁₉NO₈S

Min-yan

Zhang

2018

Zeitschrift Für Kristallographie - New Crystal Structures

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C 21 H 19 NO 8 S, triclinic, P1 (no. 2), a = 7.2884(9) Å, b = 11.9469(15) Å, c = 12.2002(16) CCDC no.:1836578 Tables 1 and 2 contain details on crystal structure and measurement conditions and a list of the atoms including atomic coordinates and displacement parameters. Source of materialA solution of chrysin (3.7 mmol) in concentrated sulfuric acid (6.0 mL) was stirred at room temperature for 15 h, the mixture was poured into aniline hydrochloride saturated aqueous

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“…Similarly, Boudjelal, et al [17] have reported that apigenin reduced the glucose level in alloxan induced rats. Many reports have shown that chrysin possesses antihyperglycemic activity [16][17][18][19][20][21][22]. These finding provide convincing evidence that the effect of the PB aqueous extract in reducing the glucose level is due to the presence of apigenin 6c-glucoside and chrysin.…”

Section: Resultsmentioning

confidence: 56%

Untitled

2017

OAJPR

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Pereskia bleo Kunth (Cactaceae) is locally known as 'Jarum tujuh bilah'. It has been used traditionally by local Malays for the treatment of diabetes. This study investigates the antidiabetic activity of aqueous extract of Pereskia bleo. The leaf, stem, and root aqueous extracts of Pereskia bleo were evaluated for total phenol and flavonoid contents. The in vitro antioxidant activity was evaluated using DPPH, FRAP and metal chelating assay. The in vivo antidiabetic activity was determined in alloxan induced male Sprague Dawley rats. The LCMS/MS analysis revealed the presence of apigenin 6 glucoside and chrysin. The total phenol and flavonoid contents were highest in the stem aqueous and chloroform extracts at 6.05±0.10mgGAE/g and at 11.07±0.20mgGAE/g respectively. The alloxan induced diabetic rats showed that the leaf, stem and root aqueous extract at 500mg/kg decreased significantly with fasting plasma glucose level by 66%, 65% and 58% (p<0.001) respectively on the 25 th day compared from day zero. It also showed decreased in the total cholesterol, triglycerides and restored the HDL level. The liver function test indicated no significance difference in ALT, AST and ALP.Thus, it is concluded that the Pereskia bleo possessed the antioxidant and antidiabetic activity attributed by the presence of apigenin 6 glucoside and chrysin.

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Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats

Cited by 25 publications

References 38 publications

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

The crystal structure of benzenaminium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate hydrate, C₂₁H₁₉NO₈S

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Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats

Cited by 25 publications

References 38 publications

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

The crystal structure of benzenaminium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate hydrate, C21H19NO8S

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The crystal structure of benzenaminium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate hydrate, C₂₁H₁₉NO₈S