Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats

Olaleye, Mary Tolulope; Akinmoladun, Afolabi Clement; Ogunboye, Adebayo A.; Akindahunsi, A. A.

doi:10.1016/j.fct.2010.05.047

Cited by 115 publications

(71 citation statements)

References 26 publications

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“…Most studies that use medicinal plants show effects similar to those found in this study [11][12][13][14][15] , however all perform prophylactic treatment of toxic hepatitis, similar to PCG1 and PCG7. However, studies should focus on the analysis of the therapeutic effect of the oils, whereas hardly identifies the patients who abuse acetaminophenin before they show hepatitis.…”

Section: Discussionmentioning

confidence: 48%

“…The acetaminophenin the dose used, showed hepatotoxic effects perceived by increased dosage of ALT and AST in the control group 11,12,14 , and the copaiba oil showed no effects when administered prophylactically during a day, however for 7 days and prophylactic therapy showed similar results to those animals treated with N-Acetyl-Cysteine, showing a hepatoprotective potential of this oil.…”

Section: Discussionmentioning

confidence: 50%

“…Studies shows an effect of the plants in reduce liver damage caused by acetaminophen and some others with similar results comparing with N-AcetylCysteine, the gold standard for the treatment of this kind of liver failure [11][12][13][14][15] . This practice has been encouraged by the World Health Orgaznization 16 .…”

Section: Introductionmentioning

confidence: 96%

“…The acetaminophen and N-acetyl-cysteine were administered by gavage at a dose of 2 g/kg and 1.2 g/kg, respectively 11,12 .…”

Section: Approved By the Ethicsmentioning

confidence: 99%

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Effect of copaiba oil in hepatic damage induced by acetaminophen in rats

Teixeira

Yamaki²,

Yasojima

et al. 2013

Acta Cir. Bras.

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PURPOSE:To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol.METHODS Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized. RESULTS:The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate. CONCLUSION:Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 96%

“…The acetaminophen and N-acetyl-cysteine were administered by gavage at a dose of 2 g/kg and 1.2 g/kg, respectively 11,12 .…”

Section: Approved By the Ethicsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of copaiba oil in hepatic damage induced by acetaminophen in rats

Teixeira

Yamaki²,

Yasojima

et al. 2013

Acta Cir. Bras.

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“…The use of herbal has shown promising results, when compared with N-acetyl-cysteine (gold standard treatment for acetaminophen's hepatotoxicity), suggesting an alternative handling for the toxic liver disorder [8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Attenuation of copaiba oil in hepatic damage in rats

et al. 2014

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Parinari curatellifolia seed flavonoids protect against Triton‐induced dyslipidemia and atherogenicity in rats

Crown

Komolafe

Akinmoladun

et al. 2017

Traditional & Kampo Medicine

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Aim: Parinari curatellifolia seed flavonoid extract (PFE) and crude methanol extract (PME) were investigated for their effects on Triton X-100 (TRT; 200 mg/kg i.p.)-induced dyslipidemia in rats. Methods: Experimentally induced hyperlipidemic and un-induced, normal rats were treated with nicotinic acid (300 mg/kg), PFE (20, 25, 30 mg/kg) or PME (100, 150 mg/kg) once daily by gavage for 10 days, following which the biochemistry and histology of the heart, aorta and sera were analyzed. Results: The seed extracts produced slight decreases in serum activities of the cardiac markers creatine kinase and lactate dehydrogenase, and did not perturb the cardiac antioxidant status of normal rats. TRT promoted cardiac oxidative stress, decreased high-density lipoprotein cholesterol (75%, P < 0.001) and increased total cholesterol (TC; 97%, P < 0.001), triglycerides (138%, P < 0.001), low-density lipoprotein cholesterol (LDL-c; 281%, P < 0.001), coronary risk index (CRI; sixfold) and atherogenic risk index (ARI; 13-fold). PFE (20 mg/kg) and PME (150 mg/kg), respectively, restored cardiac antioxidant status and significantly ameliorated the astronomical changes produced by TRT as regards TC (56% and 31%), triglycerides (70% and 66%), LDL-c (96% and 46%), CRI (92% and 78%) and ARI (99% and 83%), with relatively better efficacy than the reference compound, nicotinic acid (P < 0.01/0.001). In addition, improved heart and aortic histological architecture was observed in rats treated with both extracts. On high-performance liquid chromatography screening, kaempferol, rutin, and quercitrin were identified as some of the active phytochemicals in PFE. Conclusion: P. curatellifolia seed flavonoids have remarkable anti-hyperlipidemic and anti-atherogenic effects in acute dyslipidemia caused by TRT.

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Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats

Cited by 115 publications

References 26 publications

Effect of copaiba oil in hepatic damage induced by acetaminophen in rats

Effect of copaiba oil in hepatic damage induced by acetaminophen in rats

Attenuation of copaiba oil in hepatic damage in rats

Parinari curatellifolia seed flavonoids protect against Triton‐induced dyslipidemia and atherogenicity in rats

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