Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats

Bourogâa, Ezzeddine; Nciri, Riadh; Mezghani-Jarraya, Raoudha; Racaud‐Sultan, Claire; Damak, Mohamed; Feki, Abdelfattah El

doi:10.1007/s13105-012-0206-7

Cited by 35 publications

(23 citation statements)

References 25 publications

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“…Acute or chronic ethanol exposure induces Cyp2E1, which can generate ROS (Lu and Cederbaum, 2008). Chronic alcohol exposure to rat also leads to the reduced antioxidant enzymes including catalase, superoxide dismutase, and glutathione peroxidase in liver (Bourogaa et al, 2013). Increased ROS production can directly damage mitochondrial proteins and mitochondria DNA, induce mitochondrial depolarization and onset of mitochondrial permeability transition (MPT) (Hoek et al, 2002).…”

Section: Activation Of Mitochondrial (Intrinsic) Apoptotic Pathway Bymentioning

confidence: 99%

A Mechanistic Review of Cell Death in Alcohol‐Induced Liver Injury

Wang

Pacher

et al. 2016

Alcoholism Clin & Exp Res

102

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Alcoholic liver disease is a major health problem in the United States and worldwide without successful treatments. Chronic alcohol consumption can lead to alcoholic liver disease (ALD), which is characterized by steatosis, inflammation, fibrosis, cirrhosis and even liver cancer. Recent studies suggest that alcohol induces both cell death and adaptive cell survival pathways in the liver, and the balance of cell death and cell survival ultimately decides the pathogenesis of ALD. This review summarizes the recent progress on the role and mechanisms of apoptosis, necroptosis and autophagy in the pathogenesis of ALD. Understanding the complex regulation of apoptosis, necrosis and autophagy may help to develop novel therapeutic strategies by targeting all three pathways simultaneously.

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Section: Activation Of Mitochondrial (Intrinsic) Apoptotic Pathway Bymentioning

confidence: 99%

A Mechanistic Review of Cell Death in Alcohol‐Induced Liver Injury

Wang

Pacher

et al. 2016

Alcoholism Clin & Exp Res

102

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“…Of particular interest, Hammada scoparia is a medicinal plant known to exhibit a broad spectrum of biological, pharmacological, and therapeutic activities (Bourogaa et al, 2011(Bourogaa et al, , 2013ElRhaffari et al, 2002;Mezghani-Jarraya et al, 2009). Hammada scoparia (Pomel) Iljin (Chenopodiaceae) is locally known in Tunisia as ''Rimth''.…”

Section: Introductionmentioning

confidence: 99%

“…Hammada scoparia (Pomel) Iljin (Chenopodiaceae) is locally known in Tunisia as ''Rimth''. Several in vivo studies reported that polar extracts of H. scoparia leaves has potent antioxidative activity and hepatoprotective effects against ethanol-induced liver injury in male rats (Bourogaa et al, 2013(Bourogaa et al, , 2014.…”

Section: Introductionmentioning

confidence: 99%

Protective effects ofHammada scopariaflavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion

Saidi

Bourogâa

Bouaziz

et al. 2015

Pharmaceutical Biology

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Context: Hepatic ischemia/reperfusion injury (IRI) is a major cause of liver damage during liver surgery and transplantation. Plants have historically been used in treating liver damage, and Hammada scoparia (Pomel) (Chenopodiaceae) has been reported to possess a broad spectrum of pharmacological and therapeutic activities. Objective: In this study, a flavonoid-enriched fraction was used before the warm ischemia (WI) process as pharmacological preconditioning and in combination with technical postconditioning to evaluate their protective effects. Materials and methods: The rats were divided into five groups: a sham group; a control group (Control-IR) that was submitted to 60 min WI; a Pharmacological Preconditioning group (PreC-IR) that received flavonoid-enriched fraction (200 mg/kg body weight); a Postconditioning group (PostC) and a PreC + PostC group. Results: The use of the flavonoid-enriched fraction was noted to significantly (p50.05) reduce liver injury, as evidenced by the decrease in liver transaminase activities (AST and ALT) and lactic dehydrogenase (LDH), alkaline phosphatase (ALP), and lipid peroxidation (TBARS), levels as well as the enhancement of antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)) responses. The results also indicated that, compared with the separate application of pharmacological preconditioning and postconditioning, the combination of both treatments was more effective in reducing tissue oxidative stress levels through modulating SOD, GSH-PX, and CAT activities. Furthermore, the combined protocol further decreased the liver morphological score compared with solo treatment. Discussion and conclusion: Overall, the results indicate that the H. scoparia flavonoid-enriched fraction could be a promising candidate for future application as a pharmacological preconditioning agent against hepatic IRI.

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“…In contrast, other studies have shown significant increase in TBARS levels after chronic ethanol ingestion (Cigremis et al 2004;Adaramoye and Aluko 2011). Chronic alcohol consumption has been linked to a decrease in SOD and CAT activities in liver, heart, brain, kidney and blood (Husain et al 2001;Ozaras et al 2003;Dinu et al 2005;Bourogaa et al 2015Bourogaa et al , 2014Bourogaa et al , 2013. Chronic alcohol consumption has been linked to a decrease in SOD and CAT activities in liver, heart, brain, kidney and blood (Husain et al 2001;Ozaras et al 2003;Dinu et al 2005;Bourogaa et al 2015Bourogaa et al , 2014Bourogaa et al , 2013.…”

Section: Resultsmentioning

confidence: 94%

Therapeutic Efficacy ofHammada scopariaExtract Against Ethanol Induced Renal Dysfunction in Wistar Rats

Bourogâa

Raoudha

Damak

et al. 2016

Journal of Food Biochemistry

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Renoprotective effect of Hammada scoparia extracts was evaluated in Wistar albino rats which were distributed into five groups of six animals each. Three groups were treated simultaneously with ethanol 35% (4 g/kg) and plant extracts for 4 weeks. Other animals (EtOH) were given ethanol alone, and the control received 0.9% NaCl. The results showed that methanolic extract attenuated the increase of TBARS in kidneys, and also enhanced antioxidant status of the rats by increasing the levels of superoxide dismutase, catalase and glutathione peroxidase by 42, 32 and 49%, respectively. The glycogen synthase kinase‐3β and proline‐rich tyrosine kinase 2 were overexpressed in kidneys of ethanol‐treated rats, but was normalized after methanolic extract administration. The results suggest that the renal protection of H. scoparia leaf extract was caused by inactivation of GSK‐3β expression which leads to enhancement of antioxidant activity in the kidney and a decrease in lipid peroxidation rate. Practical Application Hammada scoparia (Chenopodiaceae) is widely used in North African traditional medicine, as prevention against several diseases such cancer, hepatitis, inflammation and obesity. Recent studies have also shown that H. scoparia leaves extract possessed molluscicidal activity, a potent antitumoral activity and hepatoprotective effect. Taking into consideration the ability of natural components to reduce several diseases, the present study has evaluated the renoprotective effect of H. scoparia leaves extract which may prove to be effective against ethanol‐induced renal disorders.

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Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats

Cited by 35 publications

References 25 publications

A Mechanistic Review of Cell Death in Alcohol‐Induced Liver Injury

A Mechanistic Review of Cell Death in Alcohol‐Induced Liver Injury

Protective effects ofHammada scopariaflavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion

Therapeutic Efficacy ofHammada scopariaExtract Against Ethanol Induced Renal Dysfunction in Wistar Rats

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