Therapeutic Efficacy ofHammada scopariaExtract Against Ethanol Induced Renal Dysfunction in Wistar Rats

Abstract

Renoprotective effect of Hammada scoparia extracts was evaluated in Wistar albino rats which were distributed into five groups of six animals each. Three groups were treated simultaneously with ethanol 35% (4 g/kg) and plant extracts for 4 weeks. Other animals (EtOH) were given ethanol alone, and the control received 0.9% NaCl. The results showed that methanolic extract attenuated the increase of TBARS in kidneys, and also enhanced antioxidant status of the rats by increasing the levels of superoxide dismutase, catalase and glutathione peroxidase by 42, 32 and 49%, respectively. The glycogen synthase kinase‐3β and proline‐rich tyrosine kinase 2 were overexpressed in kidneys of ethanol‐treated rats, but was normalized after methanolic extract administration. The results suggest that the renal protection of H. scoparia leaf extract was caused by inactivation of GSK‐3β expression which leads to enhancement of antioxidant activity in the kidney and a decrease in lipid peroxidation rate. Practical Application Hammada scoparia (Chenopodiaceae) is widely used in North African traditional medicine, as prevention against several diseases such cancer, hepatitis, inflammation and obesity. Recent studies have also shown that H. scoparia leaves extract possessed molluscicidal activity, a potent antitumoral activity and hepatoprotective effect. Taking into consideration the ability of natural components to reduce several diseases, the present study has evaluated the renoprotective effect of H. scoparia leaves extract which may prove to be effective against ethanol‐induced renal disorders.

A systematic review on Hammada scoparia medicinal plant: Phytochemicals, traditional uses and biological activities

“…In the search for substances that might reduce cell adhesion-mediated drug resistance (CAM-DR), researchers investigated the effect of Hammada scoparia extracts on adherent or suspended leukemic cells. Results demonstrate that Hammada scoparia flavonoid fraction and its constituent rutin stimulate apoptosis, particularly in adherent leukemic cells, and reduce CAM-DR (Ezzeddine et al, 2016).…”

“…Hammada scoparia is widely used in traditional medicine in North Africa (Table 2) to prevent many diseases, such as hepatitis, inflammation, and obesity (Ezzeddine et al, 2016). Several traditional applications have revealed that extracts of Hammada scoparia have anti-cancer and anti-diabetic properties (Bouaziz et al, 2016;Boulanouar et al, 2013;Hamza et al, 2019;Saidi et al, 2015;Taïbi et al, 2020).…”

“…Many Chenopodiaceae species are important components of dry or ruderal habitats (Heklau et al, 2012). Hammada scoparia is a Chenopodiaceae family species ;it is well-known for its therapeutic properties in traditional North African medicine, such as cancer, hepatitis, inflammation, and obesity prevention (Ezzeddine et al, 2016). Considering the value of natural substances in reducing the severity of diseases, the present study focuses on the traditional applications of Hammada scoparia and advances in botany, phytochemistry, and pharmacology of this plant.…”