Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Xu, Dong; Hu, Meng Jiao; Wang, Yan Qiu; Cui, Yuan‐Lu

doi:10.3390/molecules24061123

Cited by 845 publications

(636 citation statements)

References 107 publications

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“…Quercetin has a powerful antioxidant effect and can resist oxidative damage by scavenging ROS. [ 36 ] The intensities of above biomarkers in group DQ2 were decreased or increased than those in group D. These results indicate that quercetin has a protective effect against cadmium‐induced oxidative stress.…”

Section: Discussionmentioning

confidence: 81%

Serum metabonomics analysis of quercetin against the toxicity induced by cadmium in rats

Jia

Guan

Zhang

et al. 2020

J Biochem & Molecular Tox

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This study aimed to investigate the protective effect of quercetin against the toxicity induced by chronic exposure to low levels of cadmium in rats by an ultra performance liquid chromatography mass spectrometer. Rats were randomly divided into six groups as follows: control group (C), low dose of quercetin group (Q1: 10 mg/kg·bw), high dose of quercetin group (Q2: 50 mg/kg·bw), cadmium chloride group (D), low dose of quercetin plus cadmium chloride group (DQ1), and high dose of quercetin plus cadmium chloride group (DQ2). Cadmium chloride (CdCl2) was administered to rats by drinking water ad libitum in a concentration of 40 mg/L. The final amount of CdCl2 ingested was estimated from the water consumption data to be 4.85, 4.91, and 4.89 mg/kg·bw/day, for D, DQ1, and DQ2 groups, respectively. After a 12‐week treatment, the serum samples of rats were collected for metabonomics analysis. Ten potential biomarkers were identified for which intensities were significantly increased or reduced as a result of the treatment. These metabolites included isorhamnetin 4′‐O‐glucuronide, 3‐indolepropionic acid, tetracosahexaenoic acid, lysophosphatidylcholine (LysoPC) (20:5), lysoPC (18:3), lysophosphatidylethanolamine (LysoPE) (20:5/0:0), bicyclo‐prostaglandin E2, sulpholithocholylglycine, lithocholyltaurine, and glycocholic acid. Results indicated that quercetin exerted a protective effect against cadmium‐induced toxicity by regulating lipid and amino acid metabolism, enhancing the antioxidant defense system and protecting liver and kidney function.

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Section: Discussionmentioning

confidence: 81%

Serum metabonomics analysis of quercetin against the toxicity induced by cadmium in rats

Jia

Guan

Zhang

et al. 2020

J Biochem & Molecular Tox

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“…The nanotechnology based strategies are believed to improve the solubility and bioactivity of nutraceuticals. Furthermore, there are few reports available on antioxidant activity of curcumin and quercetin . To the best of our knowledge, antioxidant activity for other nutraceuticals studied in the present investigation has not been yet reported.…”

Section: Resultsmentioning

confidence: 82%

“…Furthermore, there are few reports available on antiox-idant activity of curcumin and quercetin. [24][25] To the best of our knowledge, antioxidant activity for other nutraceuticals studied in the present investigation has not been yet reported. This prompted us to investigate antioxidant activity of 1-6 NPs and corresponding bulk compounds using in vitro 2,2-diphenyl-1picrylhydrazyl (DPPH) and nitric oxide (NO) radical scavenging assays.…”

Section: Introductionmentioning

confidence: 99%

Anticancer, Antioxidant and Antiangiogenic Activities of Nanoparticles of Bioactive Dietary Nutraceuticals

et al. 2019

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Many nutraceuticals are highly potent, nontoxic, bioactive agents present in dietary vegetables, fruits and spices. They exhibit immune‐modulatory, antioxidant and anticancer activity. The major disadvantage of nutraceuticals is their low aqueous solubility and hence poor bioavailability hindering their therapeutic applications. In the present work, we herein report preparation of nanoparticles of bioactive nutraceuticals such as curcumin (1), quercetin (2), anthraquinone (3), xanthone (4), flavone (5) and vanillin (6) with a view to improve their aqueous‐phase solubility and evaluate their anticancer, antiangiogenic and antioxidant activities. The nanoparticles were prepared by controlled flow rate reprecipitation technique and characterized by spectral and microscopic techniques. Most of the nanoparticles displayed higher in‐vitro anticancer, antioxidant and in‐ovo antiangiogenic activities as compared to the corresponding bulk compounds. The biological activities of nutraceuticals are marked increased by particle size reduction to the nanoscale.

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“…It has been suggested that phenolic hydroxyl groups contribute to the free radical scavenging activity of the molecules (Bors et al, 1990). The health benefits of quercetin are generally attributable to its antioxidant action positively impacting on glutathione and reactive oxygen species (ROS) (Xu et al, 2019). The anti-oxidant action is in part mediated by the modulation of enzymes associated with oxidative stress like acetylcholinesterase and butyrylcholinesterase (Xu et al, 2019).…”

Section: Glycosylated Flavonoidsmentioning

confidence: 99%

Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics

et al. 2020

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Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addressed. Next, focus is given to glycosidases, the central theme of the review. The therapeutic value of plant glycosidases is discussed as well as the present production in plant platforms of therapeutic human glycosidases used in enzyme replacement therapies. The increasing knowledge on glycosidases, including structure and catalytic mechanism, is described. The novel insights have allowed the design of functionalized highly specific suicide inhibitors of glycosidases. These so-called activity-based probes allow unprecedented visualization of glycosidases cross-species. Here, special attention is paid on the use of such probes in plant science that promote the discovery of novel enzymes and the identification of potential therapeutic inhibitors and chaperones.

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Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Cited by 845 publications

References 107 publications

Serum metabonomics analysis of quercetin against the toxicity induced by cadmium in rats

Serum metabonomics analysis of quercetin against the toxicity induced by cadmium in rats

Anticancer, Antioxidant and Antiangiogenic Activities of Nanoparticles of Bioactive Dietary Nutraceuticals

Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics

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