Antioxidant Activities of Buckwheat Hull Extract toward Various Oxidative Stress in Vitro and in Vivo.

Mukoda, T; Sun, Bo; Ishiguro, Aya

doi:10.1248/bpb.24.209

Cited by 60 publications

(36 citation statements)

References 25 publications

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“…8,10,16) Buckwheat (Fagopyrum esculentum) is a health food in that it is rich in flavonoids such as rutin. 17) Rutin is an effective radical scavenger, 18) and Mukoda et al 19) have reported that buckwheat hull extract showed strong antioxidant activities in vitro and in vivo. Human intestinal epithelial cells have been used to study the effects of health foods on the mucosal immune response.…”

mentioning

confidence: 99%

Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

Ishii

Katsumura

Shiozuka

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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mentioning

confidence: 99%

Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

Ishii

Katsumura

Shiozuka

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…SOD activity in serum was also significantly rose by buckwheat hull extract treatment. Buckwheat hull extract was shown to be effective for protecting biological systems against various oxidative stresses in vitro, and to have antioxidant activity in vivo [71].Buckwheat honey samples were tested for inhibition of reactive oxygen species (ROS) production by activated human PMNs, antioxidant activity (scavenging of superoxide anion in a cell-free system) and inhibition of human complement (reducing levels of ROS by limiting formation of complement factors that attract and stimulate PMNs). Most honey samples were shown to be active inhibitors of reactive oxygen species [72].…”

Section: Iii-pharmacological Effectsmentioning

confidence: 99%

A review on Fagopyrum esculentum: A potential medicinal plant

Al-Snafi¹

2017

IOSRPHR

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Fagopyrum esculentum contained alkaloids, amino acids, anthraquinones, carbohydrates, flavonoids, phlobatannins and tannins. The nutritional analysis of Fagopyrum esculentum flour and bran revealed that they contained starch: 55, 75 and 18%; proteins: 12, 6 and 36%; lipids: 4, 1 and 11%; soluble carbohydrates: 2, 1 and 6%; total dietary fibers: 7, 3 and 15%; and ash: 2, 1 and 7% respectively. The pharmacological studies showed that Fagopyrum esculentum possessed antioxidant, antiinflammatory, cardiovascular, hypolipidemic, antigenotoxic, antidiabetic, reno-protective, anticancer, antimicrobial, wound healing, antistress, protected memory impairment and photoprotective effects. This review will highligh the chemical constituents and pharmacological effects of Fagopyrum esculentum.

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“…In this experiment, we focused on the action of buckwheat polyphenol (BWP) extracted from Fagopyrum esculentum MOENCH on neuronal injury induced by repeated cerebral ischemia. Buckwheat shows cholesterol-lowering effects (8), antihypertensive effects by inhibiting angiotensin 1-converting enzyme (9), antioxidant activities (10), and improves constipation and obesity. BWP contains many polyphenolic compounds such as catechin, epicatechin, rutin, hyperoside, quercetin, and oligomers of catechin and epicatechin.…”

Section: +mentioning

confidence: 99%

Protective Effect of Buckwheat Polyphenols Against Long-Lasting Impairment of Spatial Memory Associated With Hippocampal Neuronal Damage in Rats Subjected to Repeated Cerebral Ischemia

Mishima

Egashira

et al. 2004

J Pharmacol Sci

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Abstract. In the present experiment, we studied the action of buckwheat polyphenol (BWP, from Fagopyrum esculentum MOENCH) in a repeated cerebral ischemia model, which induced a strong and long-lasting impairment of spatial memory in 8-arm radial maze with hippocampal CA1 cell death in rats. BWP (600 mg / kg, continuous 21-day p.o.) significantly ameliorated not only the impairment of spatial memory in the 8-arm radial maze, but also necrosis and TUNELpositive cells in the hippocampal CA1 area subjected to repeated cerebral ischemia (10 min´2 times occlusion, 1-h interval) in rats. In order to investigate the mechanism of BWP protective action, we measured the release of glutamate and NO x -(NO 2 -+ NO 3 -) production induced by repeated cerebral ischemia in the rat dorsal hippocampus using microdialysis. A 14-day BWP treatment significantly inhibited the excess release of glutamate after the second occlusion. In addition, the BWP remarkably suppressed a delayed increase in NO x -(NO 2 -+ NO 3 -) induced by repeated cerebral ischemia in the dorsal hippocampus as determined in vivo by microdialysis. However, the 14-day treatment did not affect hippocampal blood flow in either intact rats or rats subjected to repeated ischemia measured by lasser Doppler flowmeter. These results suggested that BWP might ameliorate spatial memory impairment by inhibiting glutamate release and the delayed generation of NO x -in rats subjected to repeated cerebral ischemia.

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Antioxidant Activities of Buckwheat Hull Extract toward Various Oxidative Stress in Vitro and in Vivo.

Cited by 60 publications

References 25 publications

Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

A review on Fagopyrum esculentum: A potential medicinal plant

Protective Effect of Buckwheat Polyphenols Against Long-Lasting Impairment of Spatial Memory Associated With Hippocampal Neuronal Damage in Rats Subjected to Repeated Cerebral Ischemia

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